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Article
Open AccessCharacterization and comparative profiling of the small RNA transcriptomes in two phases of locust
All the reports on insect small RNAs come from holometabolous insects whose genome sequence data are available. Therefore, study of hemimetabolous insect small RNAs could provide more insights into evolution a...
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Article
Open AccessGonadal transcriptomic analysis and differentially expressed genes in the testis and ovary of the Pacific white shrimp (Litopenaeus vannamei)
The Pacific white shrimp (Litopenaeus vannamei) is the world’s most prevalent cultured crustacean species. However, the supply of high-quality broodstocks is limited and baseline information related to its reprod...
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Article
Selection and characterization of Oenococcus oeni strains for use as new malolactic fermentation starter cultures
Oenococcus oeni (O. oeni) strains are critically important for winemaking. They bring microbial stabilization, de-acidification and sensory improvement through malolactic fermentation (ML...
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Article
MicroRNA regulation of macrophages in human pathologies
Macrophages play a crucial role in the innate immune system and contribute to a broad spectrum of pathologies, like in the defence against infectious agents, in inflammation resolution, and wound repair. In th...
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Article
Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair
MicroRNAs (miRNAs) coordinate vascular repair by regulating injury-induced gene expression in vascular smooth muscle cells (SMCs) and promote the transition of SMCs from a contractile to a proliferating phenot...
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Article
Screening for potential probiotic from spontaneously fermented non-dairy foods based on in vitro probiotic and safety properties
The aim of this study was to screen potential probiotic lactic acid bacteria from Chinese spontaneously fermented non-dairy foods by evaluating their probiotic and safety properties. All lactic acid bacteria (...
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Article
Open AccessCCL14 serves as a novel prognostic factor and tumor suppressor of HCC by modulating cell cycle and promoting apoptosis
CCL14 is a member of CC chemokines and its role in hepatocellular carcinoma (HCC) is still unknown. In this study, CCL14 expression were analyzed by tissue microarray (TMA) including 171 paired tumor and perit...
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Article
Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance
The successful treatment of human cancers by immunotherapy has been made possible by breakthroughs in the discovery of immune checkpoint regulators, including CTLA-4 and PD-1/PD-L1. However, the immunosuppress...
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Article
Open AccessPSMC2 knockdown suppressed tumor progression of skin cutaneous melanoma
Skin cutaneous melanoma (SKCM) is the most lethal tumor among three of the major malignant cancers of the skin. The mechanism underlying the malignant biological behaviors of SKCM is not fully clear. Our study...
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Article
Open AccessMori fructus aqueous extracts attenuates liver injury by inhibiting ferroptosis via the Nrf2 pathway
Liver fibrosis and hepatocellular carcinogenesis secondary to liver fibrosis are serious liver diseases with no effective treatments. Mori fructus aqueous extracts (MFAEs) have served as successful treatments for...
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Article
Open AccessDecoding the metastatic potential and optimal postoperative adjuvant therapy of melanoma based on metastasis score
Metastasis is a formidable challenge in the prognosis of melanoma. Accurately predicting the metastatic potential of non-metastatic melanoma (NMM) and determining effective postoperative adjuvant treatments fo...
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Article
PTBP1 as a potential regulator of disease
Polypyrimidine tract-binding protein 1 (PTBP1) is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which plays a key role in alternative splicing of precursor mRNA and RNA metabolism. PT...
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Article
The complete chloroplast genome of white towel gourd (Luffa cylindrica) and phylogenetic analysis
White towel gourd (Luffa cylindrica) is an important cultivated vegetable and economic plant belong to the Cucurbitaceae family. In this study, the complete cp genome of L. cylindrica was successfully sequenced u...
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Article
Open AccessCircular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1
Circular RNAs (circRNAs) have been documented to play crucial roles in the biology of various cancers. However, their investigation in melanoma is still at an early stage, particularly as a broader mechanism b...