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Open AccessPIKfyve, expressed by CD11c-positive cells, controls tumor immunity
Cancer treatment continues to shift from utilizing traditional therapies to targeted ones, such as protein kinase inhibitors and immunotherapy. Mobilizing dendritic cells (DC) and other myeloid cells with anti...
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Open AccessAuthor Correction: Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer
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Open AccessHighly Thermally Conductive and Structurally Ultra-Stable Graphitic Films with Seamless Heterointerfaces for Extreme Thermal Management
Presenting the first investigation into the structurally bubbling-failure mechanism of graphitic film during cyclic liquid nitrogen shocks.
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Open AccessPreeclampsia-associated lncRNA FEZF1-AS1 regulates cell proliferation and apoptosis in placental trophoblast cells through the ELAVL1/NOC2L axis
LncRNAs have been shown to be involved in and control the biological processes of multiple diseases, including preeclampsia (PE). The impairment of trophoblast cell proliferation is recognized as a significant...
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Open AccessCorrection: The value of the wireless stethoscope in patients with COVID-19 infection in a makeshift hospital
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Open AccessThe value of the wireless stethoscope in patients with COVID-19 infection in a makeshift hospital
When COVID-19 sweeps the world, traditional stethoscopes are seen as infectious agents and then the use of stethoscopes is limited especially when health providers were in their personal protective equipment. ...
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Open AccessReal-world evaluation of the Stemoscope electronic tele-auscultation system
With the spread of COVID-19, telemedicine has played an important role, but tele-auscultation is still unavailable in most countries. This study introduces and tests a tele-auscultation system (Stemoscope) and...
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Comparative Transcriptomic and Metabolomic Profiling of Grapevine Leaves (cv. Kyoho) upon Infestation of Grasshopper and Botrytis cinerea
Grapes (Vitis sp.) are susceptible to infection by grasshopper and fungus that lead to damaging productivity and economic losses. In this study, we infected the young and old leaf of grapevine by Acrida chinensis
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Open AccessFactors associated with fetal karyotype in spontaneous abortion: a case-case study
Most embryos that spontaneously abort during early pregnancy are found to have chromosomal abnormalities. The purpose of this study is to explore the factors involved in chromosome aberrations during embryogen...
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Article
Surface disorder engineering in ZnCdS for cocatalyst free visible light driven hydrogen production
Metal chalcogenide solid solution, especially ZnCdS, has been intensively investigated in photocatalytic H2 generation due to their cost-effective synthetic procedure and adjustable band structures. In this work,...
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Open AccessTargeting SWI/SNF ATPases in enhancer-addicted prostate cancer
The switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin remodelling1 and is altered in over 20% of cancers2,3. Here we developed a proteolysis-targeting chimera (PROTAC) degrader of t...
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Autophagy inhibition by targeting PIKfyve potentiates response to immune checkpoint blockade in prostate cancer
Multi-tyrosine kinase inhibitors (MTKIs) have thus far had limited success in the treatment of castration-resistant prostate cancer (CRPC). Here, we report a phase I–cleared orally bioavailable MTKI, ESK981, w...
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Open AccessCharacterization of SARS-CoV-2 and host entry factors distribution in a COVID-19 autopsy series
SARS-CoV-2 is a highly contagious virus that causes the disease COVID-19. We have recently reported that androgens regulate the expression of SARS-CoV-2 host entry factors ACE2 and TMPRSS2, and androgen recept...
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Open AccessAnalysis of the etiologies of female infertility in Yunnan minority areas
The present study aims to provide a comparative analysis of the etiologies of female infertility between Dehong, on the Yunnan Frontier, and Kunming.
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Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination
Metastasis is the primary cause of cancer mortality, and cancer frequently metastasizes to the liver. It is not clear whether liver immune tolerance mechanisms contribute to cancer outcomes. We report that liv...
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Open AccessAnalysis of pregnancy outcome after anastomosis of oviduct and its influencing factors
This study aims to investigate the influencing factors of pregnancy after laparoscopic oviduct anastomosis.
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Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer
Forkhead box A1 (FOXA1) is a pioneer transcription factor that is essential for the normal development of several endoderm-derived organs, including the prostate gland1,2. FOXA1 is frequently mutated in hormone-r...
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Clonal analysis of early-stage bilateral papillary thyroid cancer identifies field cancerization
Bilaterality is a newly identified indicator for aggressive tumor behavior and poor outcome in papillary thyroid cancer. However, the clonal origin of these bilateral tumors remains unclear.
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A facile surfactant-free synthesis of Rh flower-like nanostructures constructed from ultrathin nanosheets and their enhanced catalytic properties
Rh is an important catalyst that is widely used in a variety of organic reactions. In recent years, many efforts have focused on improving its catalytic efficiency by fabricating catalyst nanoparticles with co...
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Activating ESR1 mutations in hormone-resistant metastatic breast cancer
Arul Chinnaiyan and colleagues report the results of prospective clinical sequencing of 11 estrogen receptor–positive metastatic breast cancers. They identify ESR1 mutations affecting the ligand-binding domain in...
