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Article
Open AccessDeletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice
Enhanced glycolysis is a crucial metabolic event that drives the development of liver fibrosis, but the molecular mechanisms have not been fully understood. Lactate is the endproduct of glycolysis, which has r...
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Article
Improving the Visible Light Absorption and Photocatalytic Degradation Activity of TiO2 Particles Towards MB by Organic Sensitizer Decoration
Due to the advantages of non-toxicity, high chemical stability, high activity and low cost, TiO2 is deemed as ideal material for photocatalytic degradation. However, due to its relatively high band-gap energy, an...
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Article
Open AccessThe global distribution of the macrolide esterase EstX from the alpha/beta hydrolase superfamily
Macrolide antibiotics, pivotal in clinical therapeutics, are confronting resistance challenges mediated by enzymes like macrolide esterases, which are classified into Ere-type and the less studied Est-type. In...
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Article
Open AccessUSP9X-mediated REV1 deubiquitination promotes lung cancer radioresistance via the action of REV1 as a Rad18 molecular scaffold for cystathionine γ-lyase
Radioresistance is a key clinical constraint on the efficacy of radiotherapy in lung cancer patients. REV1 DNA directed polymerase (REV1) plays an important role in repairing DNA damage and maintaining genomic...
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Article
Open AccessYTHDF2-Mediated m6A methylation inhibition by miR27a as a protective mechanism against hormonal osteonecrosis in BMSCs
With the increasing incidence of steroid-induced necrosis of the femoral head (SNFH), numerous scholars have investigated its pathogenesis. Current evidence suggests that the imbalance between lipogenesis and ...
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Article
An adaptive impedance control method for blade polishing based on the Kalman filter
Robotic force control is crucial for precise polishing and has a significant influence on the final effects. The blade has a free-form surface in space, and the curvature changes drastically, making traditiona...
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Article
Occurrence, Species, and Health Effects of Groundwater Arsenic in Typical Rural Areas Along the Northern Foot of the Qinling Mountains, China
This research focused on the major water quality parameters and trace elements in 73 groundwater samples collected from some rural areas at the northern foot of Qinling Mountains, and the hydrochemical charact...
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Article
Kinematics and machinability using bidirectional composite vibratory finishing
Considering the poor accessibility of the current finishing process for parts with complicated geometries, a novel bidirectional composite vibratory finishing (BCVF) approach was proposed, which combined the p...
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Article
Process parameter optimization model for robotic abrasive belt grinding of aero-engine blades
Reducing carbon emissions during belt grinding is of great significance for environmentally friendly production in the manufacturing industry. In this paper, in order to better grinding aero-engine titanium a...
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Article
A novel rotary barrel finishing approach for high-performance bearing ring surfaces finishing simultaneously via floating clamp
Consistency finishing is one of the technical bottlenecks in performance-oriented manufacturing for bearing rings, while non-destructive and all-around processing is its core demand. To accomplish this objecti...
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Article
Magnetic field-assisted finishing: mechanism, application, and outlook
Magnetic field-assisted finishing (MFAF) technology, as a non-traditional surface finishing technology, has a unique advantage in machining components composed of complex shapes and difficult-to-process materi...
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Article
Advance on surface finishing technology of precision bearing cylindrical rollers
Precision bearings are key components of mechanical equipment, and their quality almost restricts the overall development level of key technologies in the equipment manufacturing industry. As the critical elem...
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Article
Open AccessDevelopment of a CD8+ T cell associated signature for predicting the prognosis and immunological characteristics of gastric cancer by integrating single-cell and bulk RNA-sequencing
The universally poor clinical outcome makes gastric cancer (GC) still a significant public health threat, the main goal of our research is to develop a prognostic signature that can forecast the outcomes and i...
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Article
Open AccessBacterial community structure and co-occurrence networks in the rhizosphere and root endosphere of the grafted apple
Compared with aerial plant tissues (such as leaf, stem, and flower), root-associated microbiomes play an indisputable role in promoting plant health and productivity. We thus explored the similarities and diff...
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Article
Open AccessTransperitoneal vs retroperitoneal laparoscopic radical nephrectomy: a double-arm, parallel-group randomized clinical trial
To compare the outcomes of patients undergoing Retroperitoneal laparoscopic Radical nephrectomy (RLRN) and Transperitoneal laparoscopic Radical nephrectomy (TLRN).
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Article
Identification of the Spatiotemporal Variability and Pollution Sources for Potential Pollutants of the Malian River Water in Northwest China Using the PCA-APCS-MLR Receptor Model
Identifying potential pollution sources of river water is a basis for effectively improving water pollution and sustainable water quality management. This study presents the analyses of the spatiotemporal vari...
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Article
You watch once more: a more effective CNN architecture for video spatio-temporal action localization
The task of spatio-temporal action localization (STAL) needs to detect the action and position of individuals in the scene. Many works cannot model spatio-temporal information well, and they usually ignore inf...
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Article
Open AccessTargeting FBXO22 enhances radiosensitivity in non-small cell lung cancer by inhibiting the FOXM1/Rad51 axis
Radioresistance is a major constraint on the efficacy of lung cancer radiotherapy, but its mechanism has not been fully elucidated. Here, we found that FBXO22 was aberrantly highly expressed in lung cancer and...
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Article
Effects of grazing on the grassland ecosystem multifunctionality of montane meadow on the northern slope of the Tianshan Mountains, China
Ecosystem multifunctionality (EMF) plays an irreplaceable role in maintaining ecological balance and safeguarding human survival and development. However, a few studies have focused on the changing patterns of...
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Chapter
Introductions
Powder bed fusion (PBF) is an additive manufacturing (AM) technology in which a heat source is used to selectively melt/sinter powder bed. Typical PBF technology includes selective laser sintering (SLS), selec...
