32 Result(s)

Article

Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein

Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3...

**aobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang… in Nature Communications (2024)

Article

In-situ noncovalent interaction of ammonium ion enabled C–H bond functionalization of polyethylene glycols

The noncovalent interactions of ammonium ion with multidentate oxygen-based host has never been reported as a reacting center in catalytic reactions. In this work, we report a reactivity enhancement process en...

Zongnan Zhang, Xueli Lv, **n Mu, Mengyao Zhao, Sichang Wang… in Nature Communications (2024)

Article

Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region

Cystine-knot peptides (CKPs) are naturally occurring peptides that exhibit exceptional chemical and proteolytic stability. We leveraged the CKP carboxypeptidase A1 inhibitor as a scaffold to construct phage-di...

Yanjie Li, Yuehua Wei, Mark Ultsch, Wei Li, Wanjian Tang… in Nature Communications (2024)

Article

Halogen doped graphene quantum dots modulate TDP-43 phase separation and aggregation in the nucleus

TDP-43 is implicated in the dynamic formation of nuclear bodies and stress granules through phase separation. In diseased states, it can further condense into pathological aggregates in the nucleus and cytopla...

Hong Zhang, Huazhang Guo, Danni Li, Yiling Zhang, Shengnan Zhang… in Nature Communications (2024)

Article

Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures

α-Synuclein forms amyloid fibrils that are critical in the progression of Parkinson’s disease and serves as the pathological hallmark of this condition. Different posttranslational modifications have been iden...

**jian Hu, Wencheng **a, Shuyi Zeng, Yeh-Jun Lim, Youqi Tao… in Nature Communications (2024)

Article

Temporal and topological properties of dynamic networks reflect disability in patients with neuromyelitis optica spectrum disorders

Approximately 36% of patients with neuromyelitis optica spectrum disorders (NMOSD) suffer from severe visual and motor disability (blindness or light perception or unable to walk) with abnormalities of whole-b...

Yao Wang, Ziwei Yang, **umei Zheng, **ao Liang, ** Chen, Ting He… in Scientific Reports (2024)

Article

Unveiling dysregulated lncRNAs and networks in non-syndromic cleft lip with or without cleft palate pathogenesis

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common congenital facial malformation with a complex, incompletely understood origin. Long noncoding RNAs (lncRNAs) have emerged as pivotal re...

Caihong Wu, Haojie Liu, Zhuorong Zhan, **nyu Zhang, Mengnan Zhang… in Scientific Reports (2024)

Article

EB1 decoration of microtubule lattice facilitates spindle-kinetochore lateral attachment in Plasmodium male gametogenesis

Faithful chromosome segregation of 8 duplicated haploid genomes into 8 daughter gametes is essential for male gametogenesis and mosquito transmission of Plasmodium. Plasmodium undergoes endomitosis in this multin...

Shuzhen Yang, Mengya Cai, Junjie Huang, Shengnan Zhang, **aoli Mo… in Nature Communications (2023)

Article

Retraction Note: Optimal scheduling of integrated energy system based on improved grey wolf optimization algorithm

Jun Du, Zongnan Zhang, Menghan Li, **g Guo, Kongge Zhu in Scientific Reports (2023)

Article

Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants

A full understanding of the inactivated COVID-19 vaccine-mediated antibody responses to SARS-CoV-2 circulating variants will inform vaccine effectiveness and vaccination development strategies. Here, we offer ...

Yubin Liu, Ziyi Wang, **nyu Zhuang, Shengnan Zhang, Zhicheng Chen… in Nature Communications (2023)

Article

Reply to: Low-frequency quantum oscillations in LaRhIn₅: Dirac point or nodal line?

Chunyu Guo, A. Alexandradinata, Carsten Putzke, Amelia Estry… in Nature Communications (2023)

Article

Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling

Cellular senescence and the senescence-associated secretory phenotype (SASP) are implicated in aging and age-related disease, and SASP-related inflammation is thought to contribute to tissue dysfunction in agi...

**a Yun, Simon Hansen, Otto Morris, David T. Madden… in Nature Communications (2023)

Article

A redox switch regulates the assembly and anti-CRISPR activity of AcrIIC1

Anti-CRISPRs (Acrs) are natural inhibitors of bacteria’s CRISPR-Cas systems, and have been developed as a safeguard to reduce the off-target effects of CRISPR gene-editing technology. Acrs can directly bind to...

Yanan Zhao, Jiaojiao Hu, Shan-Shan Yang, **g Zhong, Jian** Liu… in Nature Communications (2022)

Article

Phylogenetic analysis of Arthrospira strains from Ordos based on 16S rRNA

To study the growth rate of different Arthrospira strains, three species of Arthrospira from Ordos alkaline lake, labeled as sp.DD, sp.ER, sp.FB, one species of Arthrospira from Hasu Sea in Hohhot, labeled as sp....

**gnan Zhang, Huiting Xue, Sirui Yan, Haibo Shi, Ling Du… in Scientific Reports (2022)

Article

RETRACTED ARTICLE: Optimal scheduling of integrated energy system based on improved grey wolf optimization algorithm

The optimal scheduling problem of integrated energy system (IES) has the characteristics of high-dimensional nonlinearity. Using the traditional Grey Wolf Optimizer (GWO) to solve the problem, it is easy to fa...

Jun Du, Zongnan Zhang, Menghan Li, **g Guo, Kongge Zhu in Scientific Reports (2022)

Article

Cell-type specialization is encoded by specific chromatin topologies

The three-dimensional (3D) structure of chromatin is intrinsically associated with gene regulation and cell function^1–3. Methods based on chromatin conformation capture have mapped chromatin structures in neurona...

Warren Winick-Ng, Alexander Kukalev, Izabela Harabula, Luna Zea-Redondo… in Nature (2021)

Article

Temperature dependence of quantum oscillations from non-parabolic dispersions

The phase offset of quantum oscillations is commonly used to experimentally diagnose topologically nontrivial Fermi surfaces. This methodology, however, is inconclusive for spin-orbit-coupled metals where π-phase...

Chunyu Guo, A. Alexandradinata, Carsten Putzke, Amelia Estry… in Nature Communications (2021)

Article

Optoregulated force application to cellular receptors using molecular motors

Progress in our understanding of mechanotransduction events requires noninvasive methods for the manipulation of forces at molecular scale in physiological environments. Inspired by cellular mechanisms for for...

Yijun Zheng, Mitchell K. L. Han, Ren** Zhao, Johanna Blass… in Nature Communications (2021)

Article

Histamine H₁ receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice

Negative symptoms in schizophrenia strongly contribute to poor functional outcomes, however its pathogenesis is still unclear. Here, we found that histamine H₁ receptor (H₁R) expression in basal forebrain (BF) ch...

Li Cheng, Cenglin Xu, Lu Wang, Dadao An, Lei Jiang, Yanrong Zheng… in Nature Communications (2021)

Article

Comprehensive genomic profile of Chinese lung cancer patients and mutation characteristics of individuals resistant to icotinib/gefitinib

Lung cancer is the leading causes of cancer-related death worldwide. Precise treatment based on next-generation sequencing technology has shown advantages in the diagnosis and treatment of lung cancer. This co...

Yanhong Shang, **aofang Li, Weiwei Liu, **aoliang Shi, Shaohua Yuan… in Scientific Reports (2020)