32 Result(s)
within
**ng Yongchang
Science, Humanities and Social Sciences, multidisciplinary
Science, multidisciplinary
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Article
Open AccessLiver fibrosis as a predictor of liver failure and outcome following ALPPS among patients with primary liver cancer
The influence of liver fibrosis on the rate of liver regeneration and complications following ALPPS has yet to be fully understood. This study aimed to scrutinize the effects of liver fibrosis on the postopera...
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Article
Open AccessStructural basis for hyperpolarization-dependent opening of human HCN1 channel
Hyperpolarization and cyclic nucleotide (HCN) activated ion channels are critical for the automaticity of action potentials in pacemaking and rhythmic electrical circuits in the human body. Unlike most voltage...
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Article
Open AccessCoHIT: a one-pot ultrasensitive ERA-CRISPR system for detecting multiple same-site indels
Genetic testing is crucial for precision cancer medicine. However, detecting multiple same-site insertions or deletions (indels) is challenging. Here, we introduce CoHIT (Cas12a-based One-for-all High-speed Is...
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Open AccessEstablishment and application of a rapid visual diagnostic method for Streptococcus agalactiae based on recombinase polymerase amplification and lateral flow strips
This study aims to establish a rapid diagnostic method for Streptococcus agalactiae (GBS) based on recombinase polymerase amplification (RPA) and lateral flow strips (LFS). The best primer pairs designed by SIP g...
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Open AccessIn situ copper faceting enables efficient CO2/CO electrolysis
The copper (Cu)-catalyzed electrochemical CO2 reduction provides a route for the synthesis of multicarbon (C2+) products. However, the thermodynamically favorable Cu surface (i.e. Cu(111)) energetically favors si...
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Article
Open AccessStructural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8
The C-C motif chemokine receptor 8 (CCR8) is a class A G-protein coupled receptor that has emerged as a promising therapeutic target in cancer. Targeting CCR8 with an antibody has appeared to be an attractive ...
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Open AccessHP-LSP: A reference of land surface phenology from fused Harmonized Landsat and Sentinel-2 with PhenoCam data
Land surface phenology (LSP) products are currently of large uncertainties due to cloud contaminations and other impacts in temporal satellite observations and they have been poorly validated because of the la...
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Open AccessGenome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk
Genome-wide association studies have identified numerous variants associated with human complex traits, most of which reside in the non-coding regions, but biological mechanisms remain unclear. However, assign...
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Open AccessTransient power equalization control strategy of virtual synchronous generator in isolated island microgrid with heterogeneous power supply
In the parallel supply system of synchronous generator and virtual synchronous generator, the physical structure and control structure of the two kinds of power supply are quite different, and it is difficult ...
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Article
Open AccessChromatin organizer SATB1 controls the cell identity of CD4+ CD8+ double-positive thymocytes by regulating the activity of super-enhancers
CD4+ and CD8+ double-positive (DP) thymocytes play a crucial role in T cell development in the thymus. DP cells rearrange the T cell receptor gene Tcra to generate T cell receptors with TCRβ. DP cells differentia...
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Article
Mitochondrial base editor induces substantial nuclear off-target mutations
DddA-derived cytosine base editors (DdCBEs)—which are fusions of split DddA halves and transcription activator-like effector (TALE) array proteins from bacteria—enable targeted C•G-to-T•A conversions in mitoch...
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Article
Open AccessBoride-derived oxygen-evolution catalysts
Metal borides/borates have been considered promising as oxygen evolution reaction catalysts; however, to date, there is a dearth of evidence of long-term stability at practical current densities. Here we repor...
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Article
Open AccessContinuous warming shift greening towards browning in the Southeast and Northwest High Mountain Asia
Remote sensing and ground vegetation observation data show that climate warming promotes global vegetation greening, and the increase in air temperature in High Mountain Asia (HMA) is more than twice the globa...
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Article
Open AccessAmnion signals are essential for mesoderm formation in primates
Embryonic development is largely conserved among mammals. However, certain genes show divergent functions. By generating a transcriptional atlas containing >30,000 cells from post-implantation non-human primat...
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Open AccessAchieving high strength and ductility in ODS-W alloy by employing oxide@W core-shell nanopowder as precursor
With excellent creep resistance, good high-temperature microstructural stability and good irradiation resistance, oxide dispersion strengthened (ODS) alloys are a class of important alloys that are promising f...
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Article
Open AccessDNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes
DNA glycosylases must distinguish the sparse damaged sites from the vast expanse of normal DNA bases. However, our understanding of the nature of nucleobase interrogation is still limited. Here, we show that h...
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Open AccessRadiation dosimetry effect evaluation of a carbon fiber couch on novel uRT-linac 506c accelerator
Recently, a diagnostic helical CT is integrated into a linear accelerator, called uRT-linac 506c, whose CT scanning dataset can be directly used to do simulation. This novel structure provides a possibility fo...
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Article
Open AccessBiochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway
Biotin is an essential micro-nutrient across the three domains of life. The paradigm earlier step of biotin synthesis denotes “BioC-BioH” pathway in Escherichia coli. Here we report that BioZ bypasses the canonic...
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Open AccessA hospital based retrospective study of factors influencing therapeutic leukapheresis in patients presenting with hyperleukocytic leukaemia
Therapeutic leukapheresis is a rapid and effective method to reduce early mortality of patients with hyperleukocytic leukaemia (HLL). However, few studies on factors influencing the efficiency have been report...
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Open AccessRecombinant influenza H9N2 virus with a substitution of H3 hemagglutinin transmembrane domain showed enhanced immunogenicity in mice and chicken
In recent years, avian influenza virus H9N2 undergoing antigenic drift represents a threat to poultry farming as well as public health. Current vaccines are restricted to inactivated vaccine strains and their ...
