72 Result(s)

Article

Author Correction: Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Liang Chen, Biyun Zhu, Gaomeng Ru, Haowei Meng, Yongchang Yan… in Nature Biotechnology (2024)

Article

Development of a CRISPR-Cas12a based assay for the detection of swine enteric coronaviruses in pig herds in China

Porcine epidemic diarrhea virus (PEDV), Transmissible gastroenteritis virus (TGEV), Porcine deltacoronavirus (PDCoV) and Swine acute diarrhea syndrome coronavirus (SADS-CoV) rank among the most frequently enco...

Yongbo **a, Yue Li, Yihong He, **aowei Wang, Wen**g Qiu… in Advanced Biotechnology (2024)

Article

Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome

Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome (DS). This work investigates the underlying function of MX1, an effector gene of I-IFN,...

Zhenglong Guo, Yongchang Zhu, Hai **ao, Ranran Dai, Wenke Yang… in Biological Research (2023)

Article

A comparative study on point cloud down-sampling strategies for deep learning-based crop organ segmentation

The 3D crop data obtained during cultivation is of great significance to screening excellent varieties in modern breeding and improvement on crop yield. With the rapid development of deep learning, researchers...

Dawei Li, Yongchang Wei, Rongsheng Zhu in Plant Methods (2023)

Article

MGA-seq: robust identification of extrachromosomal DNA and genetic variants using multiple genetic abnormality sequencing

Genomic abnormalities are strongly associated with cancer and infertility. In this study, we develop a simple and efficient method — multiple genetic abnormality sequencing (MGA-Seq) — to simultaneously detect...

Da Lin, Yanyan Zou, **nyu Li, **yue Wang, Qin **ao, **aochen Gao… in Genome Biology (2023)

Article

PUM2 aggravates the neuroinflammation and brain damage induced by ischemia–reperfusion through the SLC7A11-dependent inhibition of ferroptosis via suppressing the SIRT1

Cerebral ischemia–reperfusion (I/R) injury occurs due to the restoration of blood perfusion after cerebral ischemia, which results in the damage of the brain structures and functions. Unfortunately, currently ...

Qingran Liu, Yongchang Liu, Yan Li, Zhen Hong… in Molecular and Cellular Biochemistry (2023)

Article

A neurodevelopmental epigenetic programme mediated by SMARCD3–DAB1–Reelin signalling is hijacked to promote medulloblastoma metastasis

How abnormal neurodevelopment relates to the tumour aggressiveness of medulloblastoma (MB), the most common type of embryonal tumour, remains elusive. Here we uncover a neurodevelopmental epigenomic programme ...

Han Zou, Bradley Poore, Emily E. Brown, Jieqi Qian, Bin **e… in Nature Cell Biology (2023)

Article

Tumor immune microenvironment and immunotherapy efficacy in BRAF mutation non-small-cell lung cancer

Previous small-size studies reported BRAF-mutated NSCLC patients have comparable sensitivity to immune checkpoint inhibitors (ICIs). However, how BRAF mutation affects the tumor immune microenvironment (TIME) is ...

Hui Li, Yongchang Zhang, Yanjun Xu, Zhiyu Huang, Guo** Cheng… in Cell Death & Disease (2022)

Article

FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma

Lung cancer remains one of the most common malignancies and the leading cause of cancer-related death worldwide. Forkhead box protein A1 (FOXA1) is a pioneer factor amplified in lung adenocarcinoma (LUAD). How...

Junjun Li, Yongchang Zhang, Li Wang, Min Li, Jianbo Yang, Pan Chen… in Cell Death & Disease (2022)

Article

A novel molecular subtypes and risk model based on inflammatory response-related lncrnas for bladder cancer

Inflammation and long noncoding RNAs (lncRNAs) are gradually becoming important in the development of bladder cancer (BC). Nevertheless, the potential of inflammatory response-related lncRNAs (IRRlncRNAs) as a...

Fucai Tang, Jiahao Zhang, Zechao Lu, Haiqin Liao, Chuxian Hu, Yuexue Mai… in Hereditas (2022)

Article

Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma

Chaperonin containing TCP1 subunit 3 (CCT3) acts as an oncogene in cancers, whereas its role and underlying mechanisms in lung adenocarcinoma (LUAD) are poorly understood. This study investigated the clinical ...

Kun Wang, Jian He, Changling Tu, Hui Xu, Xugang Zhang… in BMC Molecular and Cell Biology (2022)

Article

Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis

Structural derivatization of natural products has been a continuing and irreplaceable source of novel drug leads. Natural phenols are a broad category of natural products with wide pharmacological activity and...

Ding Lin, Senze Jiang, Ailian Zhang, Tong Wu… in Natural Products and Bioprospecting (2022)

Article

Phase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation

Epstein-Barr virus nuclear antigen 2 (EBNA2) is a transactivator of viral and cellular gene expression, which plays a critical role in the Epstein-Barr virus-associated diseases. It was reported that EBNA2 reg...

Yiting Yang, **dong Ye, Ranran Dai, Zhaoqiang Li, Yan Zhang… in Communications Biology (2021)