107 Result(s)
within
**ng Juan Chen
Biomedicine
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Article
Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
Expression of HoxaT and Hoxa9 is activated by proviral integration in BXH2 murine myeloid leukaemias. This result, combined with the map** of the HOXA locus to human chromosome 7p15, suggested that one of the H...
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Article
Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension
Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease of unknown etiology. The exact pathogenesis of pulmonary arterial hypertension is still not well known. In the past decades, many protein mol...
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Article
From dissection of disease pathogenesis to elucidation of mechanisms of targeted therapies: leukemia research in the genomic era
Leukemia is a group of heterozygous diseases of hematopoietic stem/progenitor cells that involves dynamic change in the genome. Dissection of genetic abnormalities critical to leukemia initiation provides insi...
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Article
NT-3 Expression in Spared DRG and the Associated Spinal Laminae as well as Its Anterograde Transport in Sensory Neurons Following Removal of Adjacent DRG in Cats
Neurotrophin-3 plays an important role in survival and differentiation of sensory and sympathetic neurons, sprouting of neurites, synaptic reorganization, and axonal growth. The present study evaluated changes...
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Article
Fibrinogen interaction of CHO cells expressing chimeric αIIb/αvβ3 integrin
The molecular mechanisms of the affinity regulation of αvβ3 integrin are important in tumor development, wound repairing, and angiogenesis. It has been established that the cytoplasmic domains of αvβ3 integrin...
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Article
Losartan reduced connexin43 expression in left ventricular myocardium of spontaneously hypertensive rats
To assess the effect of angiotensin II type 1 (AT1) receptor antagonist losartan on myocardium connexin43 (Cx43) gap junction (GJ) expression in spontaneously hypertensive rats (SHRs) and investigate possible mec...
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Article
Open AccessImproved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model
Honokiol is a major bioactive compound extracted from Magnolia. The present study was designed to determine whether liposomal honokiol has the antitumor activity against human lung cancer as well as potentiate...
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Article
Open AccessEfficient inhibition of murine breast cancer growth and metastasis by gene transferred mouse survivin Thr34→Ala mutant
Metastasis in breast cancer is a vital concern in treatment because most women with primary breast cancer have micrometastases to distant sites at diagnosis. As a member of the inhibitor of apoptosis protein (...
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Article
Synthesis and Fluorescence Properties of Lanthanide (III) Perchlorate Complexes with Bis(benzoylmethyl) Sulfoxide
A ligand with two carbonyl groups and one sulfinyl group has been synthesized by a new method and its several lanthanide (III) complexes were synthesized and characterized by element analysis, molar conductivi...
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Article
Open AccessTripeptide tyroserleutide plus doxorubicin: therapeutic synergy and side effect attenuation
Tripeptide tyroserleutide (YSL) is a novel small molecule anti-tumor polypeptide that has been shown to inhibit the growth of human liver cancer cells. In this study, we investigated the effects of YSL plus do...
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Article
Open AccessLiposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity
Honokiol is an active compound purified from magnolia that has been shown to induce cell differentiation, apoptosis, and anti-angiogenesis effects, as well as an enhancement in tumor growth delay in combinatio...
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Reference Work Entry In depth
Nucleoporin
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Article
Synthesis, Characterization, Antioxidant Activity and DNA-Binding Studies of Three Rare Earth (III) Complexes with 1-(4-Aminoantipyrine)-3-tosylurea Ligand
1-(4-Aminoantipyrine)-3-tosylurea (H2L) and its three lanthanide (III) complexes, M(H2L)3 3NO3 [where M = Nd(III), Sm(III) and Eu(III)], have been synthesized and characterized. In addition, the DNA-binding prope...
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Chapter and Conference Paper
Lipoprotein Nanoplatform for Targeted Delivery of Diagnostic and Therapeutic Agents
Low-density lipoprotein (LDL) provides a highly versatile natural nanoplatform for delivery of optical and MRI contrast agents, photodynamic therapy agents and chemotherapeutic agents to normal and neoplastic ...
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Article
Open AccessIdentification of ATP synthase beta subunit (ATPB) on the cell surface as a non-small cell lung cancer (NSCLC) associated antigen
Antibody-based immuneotherapy has achieved some success for cancer. But the main problem is that only a few tumor-associated antigens or therapeutic targets have been known to us so far. It is essential to ide...
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Article
Influence of HBV gene heterogeneity on the failure of immunization with HBV vaccines in eastern China
The influence of hepatitis B virus (HBV) gene heterogeneity on the failure of HBV vaccination in eastern China remains unknown. Here, we assigned 78 hepatitis B surface antigen (HBsAg)-carrier mothers to two g...
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Article
Heat treatment increases the incidence of alopecia areata in the C3H/HeJ mouse model
Alopecia areata (AA) is a common autoimmune disease characterized by non-scarring hair loss. Previous studies have demonstrated an association between AA and physiological/psychological stress. In this study, ...
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Reference Work Entry In depth
Nucleoporin
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Article
A simple and rapid colloidal gold-based immunochromatogarpic strip test for detection of FMDV serotype A
A sandwich format immunochromatographic assay for detecting foot-and-mouth disease virus (FMDV) serotypes was developed. In this rapid test, affinity purified polyclonal antibodies from Guinea pigs which were ...
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Article
Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China
This case–control study investigated the mutations in p53 and k-ras genes of 123 gastric carcinoma patients and 129 normal individuals from Hunan, China. By isolating genomic DNA from peripheral blood and employi...
