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Article
Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1
Biochemical crosstalk between two or more histone modifications is often observed in epigenetic enzyme regulation, but its functional significance in cells has been difficult to discern. Previous enzymatic stu...
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Article
A rate-dependent aging constitutive model of EPDM rubber
Based on the rate-dependent non-aging constitutive model and the rate-independent aging constitutive model, a rate-dependent aging constitutive model is proposed to explain the changes in mechanical properties...
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Article
Open AccessNon-Abelian braiding of Fibonacci anyons with a superconducting processor
Quantum many-body systems with a non-Abelian topological order can host anyonic quasiparticles. It has been proposed that anyons could be used to encode and manipulate information in a topologically protected ...
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Article
Au-loaded alkali metal-modified crystalline carbon nitride for photocatalytic nitrogen fixation
Crystalline heptazine carbon nitride (HCN) is an ideal photocatalyst for photocatalytic ammonia synthesis. However, the limited response to visible light has hindered its further development. As a noble metal,...
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Article
Study on the Weathering Characteristics of a Solitary Rock in Chishui Based on Pore Structure with Depth
Solitary boulders emerge in the thick-bed red sandstone in the Chishui red bed area due to weathering, which can potentially induce engineering disasters. This paper measures the porosity, pore size, pore thro...
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Article
Open AccessSerum vitamin D concentrations and sleep disorders: insights from NHANES 2011–2016 and Mendelian Randomization analysis
This investigation seeks to examine the association between serum vitamin D concentrations and the prevalence of sleep disorders, additionally elucidating the causal relationship via Mendelian Randomization (M...
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Article
High power and small spot fiber coupling system for pump sources based on symmetric stepped prisms
With the development of solid-state lasers and fiber lasers, the output power and spot size of the pump source of semiconductor lasers have higher requirements. A compact output high power and small spot fiber...
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Article
Cross-Scale Simulation of Macro/Microstructure Evolution During Selective Laser Melting of Mg–Gd–Y Alloy
Mg–10Gd–3Y alloy has excellent mechanical properties, and product preparation using SLM technology has great prospects for development. However, the state of the molten pool morphology and temperature distribu...
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Article
Capsaicin reduces blood glucose and prevents prostate growth by regulating androgen, RAGE/IGF-1/Akt, TGF-β/Smad signalling pathway and reversing epithelial-mesenchymal transition in streptozotocin-induced diabetic mice
Type 2 diabetes mellitus (T2DM) is a metabolic disease. Diabetes increases the risk of benign prostatic hyperplasia (BPH). Capsaicin is extracted from chili peppers and possesses many pharmacological propertie...
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Article
Open AccessEmerging therapeutic frontiers in cancer: insights into posttranslational modifications of PD-1/PD-L1 and regulatory pathways
The interaction between programmed cell death ligand 1 (PD-L1), which is expressed on the surface of tumor cells, and programmed cell death 1 (PD-1), which is expressed on T cells, impedes the effective activa...
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Article
Open AccessA flocking control algorithm of multi-agent systems based on cohesion of the potential function
Flocking cohesion is critical for maintaining a group’s aggregation and integrity. Designing a potential function to maintain flocking cohesion unaffected by social distance is challenging due to the uncertain...
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Article
Open AccessThe mechanism of action and experimental verification of Gan-song Yin on renal clear cell carcinoma based on network pharmacology and bioinformatics
Gan-song Yin (GSY) is originated from the scripture “Gan-song Pills”, a medical work of the Ningxia ethnic minorities, and its treatment of kidney diseases has good results. Its method of treating Renal clear ...
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Article
Open AccessSeveral first-line anti-hypertensives act on fibrosarcoma progression and PD1ab blockade therapy
Patients are typically diagnosed with both hypertension and fibrosarcoma. Medical oncologists must prescribe suitable anti-hypertensive medications while considering anti-tumor drugs. Recently, immunotherapy h...
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Article
Synergistic Fabrication of Magnetic Hypercrosslinked Porous P(VBC-DVB-AA)@Fe3O4 Microspheres for Removal of Cationic Dye
Hypercrosslinked porous polymers have become a hotspot of research by virtue of their high specific surface area, mild synthesis conditions, and wide source of monomers, which are promising adsorbents for wate...
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Article
Disturbance observer based non-singular fast terminal sliding mode control of permanent magnet synchronous motors
The existence of load disturbance can lead to the instability of permanent magnet synchronous motor (PMSM) speed control systems. Therefore, a non-singular fast terminal sliding mode control (NFTSMC) strategy ...
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Article
Open AccessThe roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming
One of the key features of cancer is energy metabolic reprogramming which is tightly related to cancer proliferation, invasion, metastasis, and chemotherapy resistance. NcRNAs are a class of RNAs having no pro...
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Article
Improvement of Perovskite CH3NH3PbI3 Films on Crystallization for Efficient Perovskite Solar Cells with Low-Temperature Anti-solvent Approach
The effect of anti-solvent IPA (isopropyl alcohol, C3H8O) treatment at low temperatures on the crystallization of perovskite CH3NH3PbI3 (MAPbI3) films has been investigated. It has been indicated that both the gr...
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Article
HPV E6/E7: insights into their regulatory role and mechanism in signaling pathways in HPV-associated tumor
Human papillomavirus (HPV) is a class of envelope-free double-stranded DNA virus. HPV infection has been strongly associated with the development of many malignancies, such as cervical, anal and oral cancers. ...
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Article
Open AccessFerritinophagy: research advance and clinical significance in cancers
Ferritinophagy, a process involving selective autophagy of ferritin facilitated by nuclear receptor coactivator 4 (NCOA4), entails the recognition of ferritin by NCOA4 and subsequent delivery to the autophagos...
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Article
Open AccessA comprehensive assessment of exome capture methods for RNA sequencing of formalin-fixed and paraffin-embedded samples
RNA-Seq analysis of Formalin-Fixed and Paraffin-Embedded (FFPE) samples has emerged as a highly effective approach and is increasingly being used in clinical research and drug development. However, the process...
