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Article
Deuterium distribution and behavior of blisters in pre-damaged and undamaged tungsten
Tungsten (W), as a plasma-facing material, is subjected to high fluence plasma, resulting in both radiation damage and deuterium (D) retention. This study explores the blistering behavior and D supersaturated ...
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Article
Metal recovery from industrial solid waste by ultrasonic-assisted hydrometallurgical leaching: a review
In the context of the circular economy, there is a need for advanced methods to recover metals from industrial waste, yet classical hydrometallurgical techniques are limited. Here, we review ultrasonic-assiste...
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Article
Full-length GSDME mediates pyroptosis independent from cleavage
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here discovered a form of pyroptosis mediated by full-length (FL) GSDME...
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Article
Rab11b promotes M1-like macrophage polarization by restraining autophagic degradation of NLRP3 in alcohol-associated liver disease
Macrophage polarization is vital to mounting a host defense or repairing tissue in various liver diseases. Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is related to th...
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Article
SoccerNet 2023 challenges results
The SoccerNet 2023 challenges were the third annual video understanding challenges organized by the SoccerNet team. For this third edition, the challenges were composed of seven vision-based tasks split into t...
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Article
Fibroblast growth factor receptor 4 deficiency in macrophages aggravates experimental colitis by promoting M1-polarization
Compelling evidence indicates that dysregulated macrophages may play a key role in driving inflammation in inflammatory bowel disease (IBD). Fibroblast growth factor (FGF)-19, which is secreted by ileal entero...
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Article
Open AccessVolatile systematics in terrestrial igneous apatite: from microanalysis to decoding magmatic processes
Apatite has been recognized as a robust tool for the study of magmatic volatiles in terrestrial and extraterrestrial systems due to its ability to incorporate various volatile components and its common occurre...
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Article
Revealing interaction of pyridinic N in N-doped carbon with Sn sites for improved CO2 reduction
N-doped carbon (NC) materials have emerged as attractive supports for metal-based catalysts, enhancing their catalytic performance through the metal–support interactions. However, gaining fundamental insights ...
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Article
Open AccessSirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder afrotheria
Sirenians of the superorder Afrotheria were the first mammals to transition from land to water and are the only herbivorous marine mammals. Here, we generated a chromosome-level dugong (Dugong dugon) genome. A co...
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Article
Manipulating chiral spin transport with ferroelectric polarization
A magnon is a collective excitation of the spin structure in a magnetic insulator and can transmit spin angular momentum with negligible dissipation. This quantum of a spin wave has always been manipulated thr...
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Article
Energy flexibility and resilience analysis of demand-side energy efficiency measures within existing residential houses during cold wave event
Using the behind-meter data, this study applied a comparison and optimization-based framework to evaluate the energy flexibility and resilience of distributed energy resources within existing houses during col...
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Article
Open AccessDiscovery of Loureirin analogues with colorectal cancer suppressive activity via regulating cell cycle and Fas death receptor
Chalcones and dihydrochalcones (DHCs) are important bioactive natural products (BNPs) isolated from traditional Chinese medicine. In this study, 13 chalcones were designed with the inspiration of Loureirin, a ...
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Article
Efficient removal of Sb(III) from wastewater using selenium nanoparticles synthesized by Psidium guajava plant extract
Antimony (Sb) pollution in aquatic ecosystems has emerged as a critical environmental issue on a global scale, emphasizing the urgent need for cost-effective and user-friendly technologies to remove Sb compoun...
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Article
Open AccessSensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice
Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerb...
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Article
Machine learning guided efficiency improvement for Sn-based perovskite solar cells with efficiency exceeding 20%
Eco-friendly lead-free tin (Sn)-based perovskites have drawn much attention in the field of photovoltaics, and the highest power conversion efficiency (PCE) of Sn-based perovskite solar cells (PSCs) has been r...
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Article
Open AccessLysine acetyltransferase 14 mediates TGF-β-induced fibrosis in ovarian endometrioma via co-operation with serum response factor
Fibrogenesis within ovarian endometrioma (endometrioma), mainly induced by transforming growth factor-β (TGF-β), is characterized by myofibroblast over-activation and excessive extracellular matrix (ECM) depos...
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Article
Open AccessMidbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice
The potential brain mechanism underlying resilience to socially transferred allodynia remains unknown. Here, we utilize a well-established socially transferred allodynia paradigm to segregate male mice into pa...
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Article
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas
Bruton’s tyrosine kinase (BTK) has emerged as a therapeutic target for B-cell malignancies, which is substantiated by the efficacy of various irreversible or reversible BTK inhibitors. However, on-target BTK m...
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Article
Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial final results
Claudin18.2 (CLDN18.2) is highly expressed with the development of various malignant tumors, especially gastrointestinal cancers, and is emerging as a new target for cancer treatment. Satricabtagene autoleucel...
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Article
Effect of TiO2 addition on microstructures and properties of MgO–CaO refractory aggregates
MgO–CaO (40 wt.% CaO) refractory aggregates were prepared using the calcined dolomite and light-burned magnesia fine powder as raw materials and TiO2 as additive. The effect of TiO2 on their phase composition, mi...
