181 Result(s)
within
**n-Ran Li
Life Sciences
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Article
Full-length GSDME mediates pyroptosis independent from cleavage
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here discovered a form of pyroptosis mediated by full-length (FL) GSDME...
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Article
Modulation of histone acetylation enables fully mechanized hybrid rice breeding
Hybrid rice has achieved high grain yield and greatly contributes to food security, but the manual-labour-intensive hybrid seed production process limits fully mechanized hybrid rice breeding. For next-generat...
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Article
Open AccessHelicobacter pylori disrupts gastric mucosal homeostasis by stimulating macrophages to secrete CCL3
Helicobacter pylori (H. pylori) is the predominant etiological agent of gastritis and disrupts the integrity of the gastric mucosal barrier through various pathogenic mechanisms. After H. pylori invades the gastr...
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Open AccessCastration alters the ileum microbiota of Holstein bulls and promotes beef flavor compounds
In the beef industry, bull calves are usually castrated to improve flavor and meat quality; however, this can reduce their growth and slaughter performance. The gut microbiota is known to exert a significant i...
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Article
Reactive oxygen species (ROS) modulate nitrogen signaling using temporal transcriptome analysis in foxtail millet
Reactive oxygen species (ROS) is a chemically reactive chemical substance containing oxygen and a natural by-product of normal oxygen metabolism. Excessive ROS affect the growth process of crops, which will le...
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Article
Open AccessCCDC28A deficiency causes sperm head defects, reduced sperm motility and male infertility in mice
Mature spermatozoa with normal morphology and motility are essential for male reproduction. The epididymis has an important role in the proper maturation and function of spermatozoa for fertilization. However,...
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Open AccessCsn5 inhibits autophagy by regulating the ubiquitination of Atg6 and Tor to mediate the pathogenicity of Magnaporthe oryzae
Csn5 is subunit 5 of the COP9 signalosome (CSN), but the mechanism by which it strictly controls the pathogenicity of pathogenic fungi through autophagy remains unclear. Here, we found that Csn5 deficiency att...
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Article
Three stilbenes from pigeon pea with promising anti-methicillin-resistant Staphylococcus aureus biofilm formation activity
Cajaninstilbene acid (CSA), longistylin A (LLA), and longistylin C (LLC) are three characteristic stilbenes isolated from pigeon pea. The objective of this study was to evaluate the antibacterial activity of t...
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Article
Intercrop** efficiently utilizes phosphorus resource in soil via different strategies mediated by crop traits and species combination
Understanding how long-term intercrop** and phosphorus (P)-fertilizer application affect soil P fractions through P-acquisition strategies is critical to maintaining soil P balance in agroecosystems.
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Article
Open AccessRevealing mitf functions and visualizing allografted tumor metastasis in colorless and immunodeficient Xenopus tropicalis
Transparent immunodeficient animal models not only enhance in vivo imaging investigations of visceral organ development but also facilitate in vivo tracking of transplanted tumor cells. However, at present, tr...
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Article
Open AccessIdentification of genomic characteristics and selective signals in Guizhou black goat
Guizhou black goat is one of the indigenous black goat breeds in the southwest region of Guizhou, China, which is an ordinary goat for mutton production. They are characterized by moderate body size, black coa...
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Article
Open AccessN4-acetylcytidine modifies primary microRNAs for processing in cancer cells
N4 acetylcytidine (ac4C) modification mainly occurs on tRNA, rRNA, and mRNA, playing an important role in the expression of genetic information. However, it is still unclear whether microRNAs have undergone ac...
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Article
A chaperone-like function of FUS ensures TAZ condensate dynamics and transcriptional activation
The Hippo pathway has important roles in organ development, tissue homeostasis and tumour growth. Its downstream effector TAZ is a transcriptional coactivator that promotes target gene expression through the f...
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Genome Assembly of Tea Plants (Camellia spp.)
Tea plant [Camellia sinensis (L.) O. Kuntze (2n = 2x = 30)] is one of the most important nonalcoholic beverage crops and widely cultivated worldwide. The presence of many repetitive contents and high heterozygosi...
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Article
Pyroptosis in neurodegenerative diseases: from bench to bedside
The central nervous system regulates all aspects of physiology to some extent. Neurodegenerative diseases (NDDs) lead to the progressive loss and dysfunction of neurons, which are particularly evident in Alzhe...
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Article
Aldehyde-amine crosslinked starch-based high-performance wood adhesive
Manufacturing green and sustainable bio-based adhesives is an effective strategy to alleviate both serious energy and environmental issues. Herein, based on the aldehyde–amine covalent reaction between dialdeh...
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Open AccessSTIM1 in tumor cell death: angel or devil?
Stromal interaction molecule 1 (STIM1) is involved in mediating the store-operated Ca2+ entry (SOCE), driving the influx of the intracellular second messenger calcium ion (Ca2+), which is closely associated with ...
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Article
Nematode-induced trap formation regulated by the histone H3K4 methyltransferase AoSET1 in the nematode-trap** fungus Arthrobotrys oligospora
The methylation of lysine 4 of histone H3 (H3K4), catalyzed by the histone methyltransferase KMT2/SET1, has been functionally identified in many pathogenic fungi but remains unexplored in nematode-trap** fun...
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Open AccessIn-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation
Harnessing hepatocytes for basic research and regenerative medicine demands a complete understanding of the genetic determinants underlying hepatocyte differentiation and maturation. Single-cell CRISPR screens...
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Open AccessLandscape of enhancer disruption and functional screen in melanoma cells
The high mutation rate throughout the entire melanoma genome presents a major challenge in stratifying true driver events from the background mutations. Numerous recurrent non-coding alterations, such as those...
