158 Result(s)
within
**n-Hai Li
Biomedicine
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Chapter
Abstracts
Expression of an activated raf transgene accelerated the terminal myeloid differentiation of HL-60 human promyelocytic leukemia cells induced by retinoic acid. A similar result was obtained when 1,25-dihydroxy...
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Article
Low Genetic Variation of the Yunnan Hare (Lepus comus G. Allen 1927) as Revealed by Mitochondrial Cytochrome b Gene Sequences
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Article
Synthetic Analogs of Green Tea Polyphenols as Proteasome Inhibitors
Animal, epidemiological and clinical studies have demonstrated the anti-tumor activity of pharmacological proteasome inhibitors and the cancer-preventive effects of green tea consumption. Previously, one of ou...
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Article
Ciona intestinalis as an emerging model organism: Its regeneration under controlled conditions and methodology for egg dechorionation
The ascidian Ciona intestinalis is a model organism of developmental and evolutionary biology and may provide crucial clues concerning two fundamental matters, namely, how chordates originated from the putative d...
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Article
Relative bioavailability and bioequivalence of metforphin hydrochloride extended-released and immediate-released tablets in healthy Chinese volunteers
The aim of the present study was to investigate the relative bioavailability and bioequivalence of a new tablet formulation of metformin hydrochloride with reference to a standard product in healthy Chinese ad...
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Article
A Feasible and Quantitative Encoding Method for Microbeads with Multicolor Quantum Dots
Multicolor encoded beads were achieved by incorporating two color core-shell quantum dots (QDs) (CdSe/ZnS) to commercial polystyrene (PS) beads. By controlling the concentration ratios of the two quantum dots ...
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Article
(5R)-5-hydroxytriptolide (LLDT-8) protects against bleomycin-induced lung fibrosis in mice
To study the protective effects of a triptolide-derived, novel compound, (5R)-5-hydroxytriptolide (LLDT-8), on bleomycin-induced lung fibrosis.
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Article
Open AccessHaplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population
Bcl-3 as an oncoprotein is overexpressed in nasopharyngeal carcinoma (NPC). Nedd4 binding protein 2 (N4BP2), which is located in the NPC susceptibility locus, is a Bcl-3 binding protein. This study is aimed to...
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Article
AICAR inhibits proliferation and induced S-phase arrest, and promotes apoptosis in CaSki cells
The aim of the present study was to determine the effect of 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) on proliferation, cell cycle, and apoptosis in the human epithelial cervical cancer cell line C...
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Article
Dendritic cell-based immunotherapy for malignant glioma
The immunotherapy for malignant glioma faces unique difficult, due to some anatomical and immunological characteristics including the existence of blood brain barrier, the absence of lymphatic tissues and dend...
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Article
An essential function for β-arrestin 2 in the inhibitory signaling of natural killer cells
Inhibitory receptors antagonize natural killer cell cytotoxicity. Ge and colleagues show that the scaffold protein β-arrestin 2 recruits the phosphatases SHP-1 and SHP-2 to the inhibitory receptor KIR2DL1 to e...
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Article
The pharmacokinetics of JS-38, a novel antineoplastic drug, in rats
To evaluate the pre-clinical pharmacokinetics of JS-38(C22H14O4N2S2F6 MW: 548), a study was conducted in Wistar rats (3 ♀, 2 ♂: 200∼250 g about 6 or 7 months). The concentration-time curve of JS-38 in rats demons...
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Article
A novel anti-cancer effect of genistein: reversal of epithelial mesenchymal transition in prostate cancer cells
The aim of the present study was to investigate whether low dose genistein affects the invasion and epithelial mesenchymal transition (EMT) of prostate cancer (PCa) cells.
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Article
Open AccessLiposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity
Honokiol is an active compound purified from magnolia that has been shown to induce cell differentiation, apoptosis, and anti-angiogenesis effects, as well as an enhancement in tumor growth delay in combinatio...
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Article
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21
Xuejun Zhang and colleagues report a genome-wide association and replication studies for psoriasis, conducted in Chinese populations. They confirm previous associations in MHC and IL12B to psoriasis susceptibilit...
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Article
Open AccessSuitable reference genes for real-time PCR in human HBV-related hepatocellular carcinoma with different clinical prognoses
Housekee** genes are routinely used as endogenous references to account for experimental differences in gene expression assays. However, recent reports show that they could be de-regulated in different disea...
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Article
Open AccessInfluencing factors and clinical significance of the metastatic lymph nodes ratio in gastric adenocarcinoma
To investigate influencing factors of the metastatic lymph nodes ratio (MLR) and whether it is related to survival in patients with gastric adenocarcinoma.
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Article
Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression
Silibinin is known to exert growth inhibition and cell death together with cell cycle arrest and apoptosis in human prostate cancer cells. Whether silibinin could inhibit the invasion, motility and migration o...
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Article
Open AccessMitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation
Caspase-independent apoptotic pathways are suggested as a mechanism for the delayed neuronal death following ischemic insult. However, the underlying signalling mechanisms are largely unknown. Recent studies i...
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Article
Open AccessMMP7 expression regulated by endocrine therapy in ERβ-positive colon cancer cells
Many studies have shown that colon cancer is an estrogen-dependent carcinoma. This study explored the efficacy of endocrine therapy in colon cancer cells with high metastatic potential (HT29). We investigated ...
