128 Result(s)

Article

Correction: Promotion of osteogenesis in BMSC under hypoxia by ATF4 via the PERK–eIF2α signaling pathway

Yuan Feng, Zhiqi Han, Weidong Jiang… in In Vitro Cellular & Developmental Biology … (2024)

Article

Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation

Hematopoietic stem and progenitor cells (HSPCs) that have impaired differentiation can transform into leukemic blasts. However, the mechanism that controls differentiation remains elusive. Here, we show that t...

Huan Liu, Lu Sun, Hongfei Zhao, Zihan Zhao, Shiyue Zhang… in Cell Death & Differentiation (2024)

Article

The OGT–c-Myc–PDK2 axis rewires the TCA cycle and promotes colorectal tumor growth

Deregulated glucose metabolism termed the “Warburg effect” is a fundamental feature of cancers, including the colorectal cancer. This is typically characterized with an increased rate of glycolysis, and a conc...

Huijuan Wang, Jie Sun, Haofan Sun, Yifei Wang, Bingyi Lin… in Cell Death & Differentiation (2024)

Article

Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment

Osteoarthritis affects 15% of people over 65 years of age. It is characterized by articular cartilage degradation and inflammation, leading to joint pain and disability. Osteoarthritis is incurable and the pat...

Hongshang Chu, Shaoyang Zhang, Zhenlin Zhang, Hua Yue… in npj Regenerative Medicine (2024)

Article

Akkermansia muciniphila Improves Depressive-Like Symptoms by Modulating the Level of 5-HT Neurotransmitters in the Gut and Brain of Mice

Accumulating evidence has suggested that the gut microbiome plays an important role in depression. Akkermansia muciniphila (AKK), a next-generation probiotic, shows a beneficial effect on immune and metabolic hom...

Huijuan Guo, **nxu Liu, Ti Chen, ** Wang, **aojie Zhang in Molecular Neurobiology (2024)

Article

MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation

Sensorineural hearing loss (SNHL) poses a major threat to both physical and mental health; however, there is still a lack of effective drugs to treat the disease. Recently, novel biological therapies, such as ...

Huan Liu, Huijuan Kuang, Yiru Wang, Lili Bao, Wanxin Cao, Lu Yu… in Biological Research (2024)

Article

Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation

High-fat diet (HFD) is closely associated with the increased prevalence of inflammatory bowel disease (IBD). Excessive gut microbial metabolite deoxycholic acid (DCA) caused by HFD plays significant roles in e...

Dan Li, Jiefei Zhou, Lingyu Wang, Zizhen Gong, Huijuan Le, Ye Huang… in Cell & Bioscience (2023)

Article

Methylation across the central dogma in health and diseases: new therapeutic strategies

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone proteins is a reversible p...

Ruochen Liu, Erhu Zhao, Huijuan Yu, Chaoyu Yuan… in Signal Transduction and Targeted Therapy (2023)

Article

Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging

Ultraviolet A (UVA) irradiation can lead to skin damage and premature skin aging known as photoaging. This work found that UVA irradiation caused an imbalance between dermal matrix synthesis and degradation th...

Yinan Li, **u Huang, **g **, Haohao Zhang, Kai Yang, **gxia Han… in Cell & Bioscience (2023)

Article

Phase separation of DDX21 promotes colorectal cancer metastasis via MCM5-dependent EMT pathway

RNA binding proteins (RBPs) contributes to cancer progression, but the underlying mechanism reminds unclear. Here, we find that DDX21, a representative RBP, is highly expressed in colorectal cancer (CRC), whic...

Huabin Gao, Huiting Wei, Yang Yang, Hui Li, Jiangtao Liang, Jiecheng Ye… in Oncogene (2023)

Article

CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that affects social interaction and behavior. Mutations in the gene encoding chromodomain helicase DNA-binding protein 8 (CHD8) lead to ...

Bang Li, Hui Zhao, Zhuchi Tu, Weili Yang, Rui Han, Lu Wang, **aopeng Luo… in Cell Discovery (2023)

Article

Correction: Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming

Zhangnan Liu, Mengzhen Fan, Junqing Hou, Si**g Pan, Yanxin Xu… in Cell Death & Disease (2023)

Article

Correction to: M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway

Hang Yin, Lin Chen, Shiqi Piao, Yiru Wang, Zhange Li… in Cell Death & Differentiation (2023)