28 Result(s)

Article

Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment

Osteoarthritis affects 15% of people over 65 years of age. It is characterized by articular cartilage degradation and inflammation, leading to joint pain and disability. Osteoarthritis is incurable and the pat...

Hongshang Chu, Shaoyang Zhang, Zhenlin Zhang, Hua Yue… in npj Regenerative Medicine (2024)

Article

Correction: Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming

Zhangnan Liu, Mengzhen Fan, Junqing Hou, Si**g Pan, Yanxin Xu… in Cell Death & Disease (2023)

Article

Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming

Serine hydroxymethyltransferase 2 (SHMT2) plays an important role in converting serine to glycine and supplying carbon to one-carbon metabolism to sustain cancer cell proliferation. However, the expression, fu...

Zhangnan Liu, Mengzhen Fan, Junqing Hou, Si**g Pan, Yanxin Xu… in Cell Death & Disease (2023)

Article

Embryonic organizer formation disorder leads to multiorgan dysplasia in Down syndrome

Despite the high prevalence of Down syndrome (DS) and early identification of the cause (trisomy 21), its molecular pathogenesis has been poorly understood and specific treatments have consequently been practi...

Yanyan Liu, Ziyuan Lin, Ying Peng, Yan Jiang, Xuan Zhang… in Cell Death & Disease (2022)

Article

Mesenchymal stem cells exosomal let-7a-5p improve autophagic flux and alleviate liver injury in acute-on-chronic liver failure by promoting nuclear expression of TFEB

Acute-on-chronic liver failure is a distinct clinical syndrome characterized by a dysregulated immune response and extensive hepatocyte death without satisfactory therapies. As a cytoplasmic degradative and qu...

Dengna Lin, Hao Chen, **g **ong, **g Zhang, Zhaoxia Hu, Juan Gao… in Cell Death & Disease (2022)

Article

SNHG25 facilitates SNORA50C accumulation to stabilize HDAC1 in neuroblastoma cells

Increasing studies have pointed out that small nucleolar RNAs (snoRNAs) and their host genes (SNHGs) have multi-functional roles in cancer progression. Bioinformatics analysis revealed the importance of snoRNA...

Huijuan Zeng, **g Pan, Chao Hu, Jiliang Yang, Jiahao Li… in Cell Death & Disease (2022)

Article

Endothelial ETS1 inhibition exacerbate blood–brain barrier dysfunction in multiple sclerosis through inducing endothelial-to-mesenchymal transition

Blood–brain barrier (BBB) dysfunction has been recognized as an early pathological feature and contributing factor in multiple sclerosis. Endothelial-to-mesenchymal transition is a process associated with endo...

Yan Luo, Hang Yang, Yan Wan, Sibo Yang, Jiehong Wu, Shengcai Chen… in Cell Death & Disease (2022)

Article

Correction: Thymidine phosphorylase promotes malignant progression in hepatocellular carcinoma through pentose Warburg effect

Qiang Zhang, Yuan Qin, Jianmin Zhao, Yuanhao Tang, Xuejiao Hu… in Cell Death & Disease (2022)

Article

Hippo-YAP/MCP-1 mediated tubular maladaptive repair promote inflammation in renal failed recovery after ischemic AKI

Acute kidney injury (AKI) is associated with significant morbidity and its chronic inflammation contributes to subsequent chronic kidney disease (CKD) development. Yes-associated protein (YAP), the major trans...

Zhihuang Zheng, Chuanlei Li, Guangze Shao, **qing Li, Kexin Xu… in Cell Death & Disease (2021)

Article

TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer

Breast cancer is one of the most common female malignant cancers. Biorhythm disorder largely increases the risk of breast cancer. We aimed to investigate the biological functions and molecular mechanisms of ci...

Shan Zhang, Peiqi Huang, Huijuan Dai, Qing Li, Lipeng Hu, **g Peng… in Cell Death & Disease (2020)

Article

FATS regulates polyamine biosynthesis by promoting ODC degradation in an ERβ-dependent manner in non-small-cell lung cancer

Polyamine biosynthesis is an essential metabolic pathway for cell growth and differentiation in non-small-cell lung cancer (NSCLC). Fragile-site associated tumour suppressor (FATS) is a novel gene involved in ...

Li Qiu, Linfei Hu, Huijuan Wang, **ling Li, **anhui Ruan… in Cell Death & Disease (2020)

Article

Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1

Exosomes are small endogenous membrane vesicles that can mediate cell communication by transferring genetic materials. Based on that, exosomes have always been discussed as a cargo carrier for microRNA (miRNA)...

Hongbo Wu, **aoqian Mu, Lei Liu, Huijuan Wu, **ufeng Hu… in Cell Death & Disease (2020)

Article

PD-L1 promotes tumor growth and progression by activating WIP and β-catenin signaling pathways and predicts poor prognosis in lung cancer

PD-L1 is overexpressed in tumor cells and contributes to cancer immunoevasion. However, the role of the tumor cell-intrinsic PD-L1 in cancers remains unknown. Here we show that PD-L1 regulates lung cancer grow...

Wendan Yu, Yijun Hua, Huijuan Qiu, Jiaojiao Hao, Kun Zou… in Cell Death & Disease (2020)

Article

Inhibiting 4E-BP1 re-activation represses podocyte cell cycle re-entry and apoptosis induced by adriamycin

Podocyte loss is one of the determining factors for the progression toward glomerulosclerosis. Podocyte is terminally differentiated and does not typically proliferate following injury and loss. However, recen...

Fang Li, **ng Mao, Qiyuan Zhuang, Zhonghua Zhao, Zhigang Zhang… in Cell Death & Disease (2019)

Article

LncRNA MIAT sponges miR-149-5p to inhibit efferocytosis in advanced atherosclerosis through CD47 upregulation

Atherosclerotic cardio-cerebrovascular disease and death remain the leading cause of morbidity and mortality worldwide. Defective efferocytosis, the clearance of apoptotic cells by macrophages, is thought to l...

Zi-ming Ye, Shuai Yang, Yuan-peng **a, Rui-ting Hu, Shengcai Chen… in Cell Death & Disease (2019)

Article

Thymidine phosphorylase promotes malignant progression in hepatocellular carcinoma through pentose Warburg effect

Tumor progression is dependent on metabolic reprogramming. Metastasis and vasculogenic mimicry (VM) are typical characteristics of tumor progression. The relationship among metastasis, VM, and metabolic reprog...

Qiang Zhang, Yuan Qin, Jianmin Zhao, Yuanhao Tang, Xuejiao Hu… in Cell Death & Disease (2019)

Article

Polyphyllin I suppresses the formation of vasculogenic mimicry via Twist1/VE-cadherin pathway

Vasculogenic mimicry (VM) is a functional microcirculation pattern formed by aggressive tumor cells and is related to the metastasis and poor prognosis of many cancer types, including hepatocellular carcinoma ...

Ting **ao, Weilong Zhong, Jianmin Zhao, Baoxin Qian, Huijuan Liu… in Cell Death & Disease (2018)

Article

Inhibition of the miR-192/215–Rab11-FIP2 axis suppresses human gastric cancer progression

Less than a century ago, gastric cancer (GC) was the most common cancer throughout the world. Despite advances in surgical, chemotherapeutic, and radiotherapeutic treatment, GC remains the number 3 cancer kill...

**ao**g Zhang, Yin Peng, Yong Huang, Shiqi Deng, **anling Feng… in Cell Death & Disease (2018)