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Article
Open AccesspyDarwin machine learning algorithms application and comparison in nonlinear mixed-effect model selection and optimization
Forward addition/backward elimination (FABE) has been the standard for population pharmacokinetic model selection (PPK) since NONMEM® was introduced. We investigated five machine learning (ML) algorithms (Gene...
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Article
Open AccessBacterial c-di-GMP triggers metamorphosis of mussel larvae through a STING receptor
Bacteria induced metamorphosis observed in nearly all marine invertebrates. However, the mechanism of bacteria regulating the larvae-juvenile metamorphosis remains unknown. Here, we test the hypothesis that c-...
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Article
Organic heterojunction synaptic device with ultra high recognition rate for neuromorphic computing
Traditional computing structures are blocked by the von Neumann bottleneck, and neuromorphic computing devices inspired by the human brain which integrate storage and computation have received more and more at...
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Article
Angiography-based Fractional Flow Reserve for the Prediction of Clinical Outcomes After Drug-coated Balloon or Plain Old Balloon Angioplasty
AccuFFRangio is a novel method for fast computation of fractional flow reserve (FFR) based on coronary angiography and computational fluid dynamics. The association between the AccuFFRangio and clinical outcom...
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Article
Open AccessCorrection: Genome-wide characterization of the tomato UDP-glycosyltransferase gene family and functional identification of SlUDPGT52 in drought tolerance
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Article
Open AccessTherapeutic efficacy of a K5-specific phage and depolymerase against Klebsiella pneumoniae in a mouse model of infection
Klebsiella pneumoniae has become one of the most intractable gram-negative pathogens infecting humans and animals due to its severe antibiotic resistance. Bacteriophages and protein products derived from them are...
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Article
Efficient osmosis-powered production of green hydrogen
Hydrogen, a clean energy carrier, has emerged as a promising solution to decarbonize the power sector and move towards a more sustainable future. However, the heavy dependence of its production on fossil fuels...
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Article
LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth
The mechanisms underlying the dynamic remodelling of cellular membrane phospholipids to prevent phospholipid peroxidation-induced membrane damage and evade ferroptosis, a non-apoptotic form of cell death drive...
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Article
Open AccessCross-species spill-over potential of the H9N2 bat influenza A virus
In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bir...
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Article
Application of Advanced Modeling Approaches Supporting Generic Product Development Under GDUFA for Fiscal Year 2023
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Article
Open AccessBacterial c-di-GMP signaling gene affects mussel larval metamorphosis through outer membrane vesicles and lipopolysaccharides
Biofilms serve as crucial cues for settlement and metamorphosis in marine invertebrates. Within bacterial systems, c-di-GMP functions as a pivotal signaling molecule regulating both biofilm formation and dispe...
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Article
Protective Autophagy Attenuates the Cytotoxicity of MTI-31 in Renal Cancer Cells by Activating the ERK Pathway
The mammalian target of rapamycin (mTOR) is a key regulatory molecular target to treat cancer, and MTI-31 is a potent mTOR inhibitory agent for the therapeutically target of the renal cell carcinoma (RCC). How...
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Article
Ba Do** Effects on the Superconductivity and Electronic Structure of K2Mo3As3
The do** effects of alkaline earth metal Ba on the quasi-one-dimensional superconductor K2Mo3As3 have been systematically investigated. A series of polycrystalline samples (K1–xBax)2Mo3As3 with nominal do** l...
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Article
GWAS identifies candidate genes affecting water absorption in foxtail millet seeds
Foxtail millet (Setaria italica) is a major cereal crop cultivated in the arid and semi-arid regions of northern China. However, achieving uniform emergence poses a significant challenge in foxtail millet cultiva...
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Article
Green synthesis of porous bamboo-based activated carbon with high VOCs adsorption performance via steam activation method
VOCs has serious impacts on the environment and humans due to its volatility. Activated carbon, as an adsorption material, has a rich pore structure and is widely used. This study uses fast-growing bamboo as a...
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Article
Open AccessHigh-performance ferroelectric field-effect transistors with ultra-thin indium tin oxide channels for flexible and transparent electronics
With the development of wearable devices and hafnium-based ferroelectrics (FE), there is an increasing demand for high-performance flexible ferroelectric memories. However, develo** ferroelectric memories th...
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Article
Open AccessHypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques
Genetic engineering of allogeneic cell therapeutics that fully prevents rejection by a recipient’s immune system would abolish the requirement for immunosuppressive drugs or encapsulation and support large-sca...
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Article
The Effect of Laser Irradiation on the Compressive Strength of Granite Under Uniaxial Compression
In order to improve the crushing efficiency of drilling machinery, laser-assisted mechanical rock-breaking technology has gained wide attention in the field of engineering construction. In this method, the wea...
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Open AccessAntimicrobial resistance survey and whole-genome analysis of nosocomial P. Aeruginosa isolated from eastern Province of China in 2016–2021
Pseudomonas aeruginosa is a major Gram-negative pathogen that can exacerbate lung infections in the patients with cystic fibrosis, which can ultimately lead to death.
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Correction to: Combining MTI‑31 with RAD001 inhibits tumor growth and invasion of kidney cancer by activating autophagy
