14,619 Result(s)
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Article
A novel coupling process to replace the traditional multi-stage anammox process—sulfur autotrophic denitrification coupled anammox system
A novel coupling process to replace the traditional multi-stage anammox process—sulfur autotrophic denitrification (SAD) coupled anaerobic ammonium oxidation (anammox) system was designed, which solved problem...
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Association Between Multiple Metal(loid)s Exposure and Blood Lipid Levels: Evidence from a Cross-Sectional Study of Southeastern China
Exposure to essential and toxic metals occurs simultaneously as a mixture in real-life. However, there is no consensus regarding the effects of co-exposure to multiple metal(loid)s (designated hereafter metals...
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Open AccessIL-4/IL-4R axis signaling drives resistance to immunotherapy by inducing the upregulation of Fcγ receptor IIB in M2 macrophages
In recent years, immunotherapy, particularly PD-1 antibodies, have significantly enhanced the outcome of gastric cancer patients. Despite these advances, some patients do not respond well to treatment, highlig...
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Research progress on differentiation and regulation of plant chromoplasts
Carotenoids, natural tetraterpenoids found abundantly in plants, contribute to the diverse colors of plant non-photosynthetic tissues and provide fragrance through their cleavage products, which also play cruc...
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Quantitative trait locus analysis of gray leaf spot resistance in the maize IBM Syn10 DH population
The exploration and dissection of a set of QTLs and candidate genes for gray leaf spot disease resistance using two fully assembled parental genomes may help expedite maize resistance breeding.
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Mass spectrometry-based proteomic landscape of rice reveals a post-transcriptional regulatory role of N6-methyladenosine
Rice is one of the most important staple food and model species in plant biology, yet its quantitative proteomes are largely uncharacterized. Here we quantify the relative protein levels of over 15,000 genes a...
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Open AccessCas12a-mediated gene targeting by sequential transformation strategy in Arabidopsis thaliana
Gene targeting (GT) allows precise manipulation of genome sequences, such as knock-ins and sequence substitutions, but GT in seed plants remains a challenging task. Engineered sequence-specific nucleases (SSNs...
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Open AccessCorrection: Mesenchymal stem cell-derived microvesicles improve intestinal barrier function by restoring mitochondrial dynamic balance in sepsis rats
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Open AccessLight signaling regulates root-knot nematode infection and development via HY5-SWEET signaling
Meloidogyne incognita is one of the most important plant-parasitic nematodes and causes tremendous losses to the agricultural economy. Light is an important living factor for plants and pathogenic organisms, and ...
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Open AccessYTH domain family protein 3 accelerates non-small cell lung cancer immune evasion through targeting CD8+ T lymphocytes
Immune evasion is one of the critical hallmarks of malignant tumors, especially non-small cell lung cancer (NSCLC). Emerging findings have illustrated the roles of N6-methyladenosine (m6A) on NSCLC immune evasion...
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A genome-wide association study of panicle blast resistance to Magnaporthe oryzae in rice
Rice blast, caused by Magnaporthe oryzae (M. oryzae), is one of the most serious diseases worldwide. Develo** blast-resistant rice varieties is an effective strategy to control the spread of rice blast and redu...
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Comparative Assessment of the Environmental and Economic Performance of Two Straw Utilization Pathways in China
Straw management is extremely challenging, and irrational treatment can cause environmental pollution and affect the development of a circular economy in agriculture. The high-value utilization of agricultural...
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Open AccessAuthor Correction: PCYT1A deficiency disturbs fatty acid metabolism and induces ferroptosis in the mouse retina
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Comprehensive genome-wide identification of Snf2 gene family and their expression profile under salt stress in six Brassica species of U’s triangle model
We comprehensively identified and analyzed the Snf2 gene family. Some Snf2 genes were involved in responding to salt stress based on the RNA-seq and qRT-PCR analysis.
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Open AccessMyofibroblasts derived type V collagen promoting tissue mechanical stress and facilitating metastasis and therapy resistance of lung adenocarcinoma cells
Lung cancer is a leading cause of cancer-related mortality globally, with a dismal 5-year survival rate, particularly for Lung Adenocarcinoma (LUAD). Mechanical changes within the tumor microenvironment, such ...
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Tracking cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection
Emerging evidence suggests that neurological and other post-acute sequelae of COVID-19 can persist beyond or develop following SARS-CoV-2 infection. However, the long-term trajectories of cognitive change afte...
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Genome-Wide Characterization of the Glycosyltransferase Family in Morus alba L. and Functional Characterization of the Flavonoid-Specific MaUGT89AS1
Mulberry is an important industrial crop and medicinal plant with a history of thousands of years. Glycosylation catalysed by glycosyltransferase (GT) is one of the most important modification reactions necess...
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Genome-wide identification and expression analysis of the SOD gene family under biotic and abiotic stresses in sweet orange
Superoxide dismutase (SOD) protects plants from biotic and abiotic stress-induced reactive oxygen species toxicity and is extensively involved in plant growth and development. As the most widely cultivated and...
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Correction: lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus
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Article
Niclosamide modulates phenotypic switch and inflammatory responses in human pulmonary arterial smooth muscle cells
Excessive proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) represent key steps of pulmonary vascular remodeling, leading to the development of pulmonary arterial hypertension (PAH...