4,026 Result(s)
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Article
Effect of RA233 alone and combined with radiation on experimental tumour metastasis. Part 1
The effect of the platelet aggregation inhibitor RA233 alone or in combination with radiation was investigated on the spontaneously metastasizing B16 melanoma and on the Lewis lung carcinoma. The effect of thi...
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Antitumour effect of RA 233 alone and combined with radiotherapy
The effect of RA233 alone or in combination with radiation was investigated in vivo on the 5180 sarcoma, the B16 melanoma and the Lewis lung carcinoma.
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Site-dependence of invasiveness of ECA109 human oesophageal carcinoma cells in nude mice
ECA109 human oesophageal carcinoma cells were injected either subcutaneously or intraperitoneally into BALB/CATc 1-nu/nu mice. After 23 weeks tumours were examined histologically and by scanning electron micro...
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Effects of neuroblastoma tumor gangliosides on platelet adhesion to collagen
Gangliosides, sialic acid-containing glycosphingolipids, enhance tumor formation in experimental animals and are associated with tumor progression and metastasis in humans. The mechanism(s) for this activity i...
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Hepatocyte growth factor stimulates the invasion of gallbladder carcinoma cell lines in vitro
Human gallbladder cancer is highly malignant and its prognosis is usually poor depending on the extent of surrounding tissue invasion. We examined in vitro the invasive activity of four gallbladder cancer cell li...
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Case-control study of oral cancer in Shenyang, Northeastern China
To investigate the risk factors of oral cancer, a hospital-based case-control study was conducted from March 1989 to September 1995 in Shenyang, Liaoning Province, China.
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Role of cyclin E and p53 expression in progression of early gastric cancer
To elucidate the role that cyclin E overexpression plays in the progression of early gastric cancer, we examined the expression of cyclin E and p53, as abnormal p53 expression is linked with cyclin E overexpress...
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Enhancement of type IV collagenases by highly metastatic variants of HT1080 fibrosarcoma cells established by a transendothelial invasion system in vitro
A novel in vitro invasion assay system was established in this laboratory, in which the invasion of tumor cells after interaction with endothelial cells could be examined. Two variant cell lines (FP-10, FP-21) we...
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Inhibition of VLA-4 and up-regulation of TIMP-1 expression in B16BL6 melanoma cells transfected with MHC class I genes
The effect of MHC class I gene transfection on the metastatic properties of B16BL6 melanoma cells was investigated. BL6-8 melanoma cells transfected with H-2K or H-2K, but not H-2D or H-2L, genes showed a dram...
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Article
Modulation of angiogenesis by human gliomaxenograft models that differentially express vascular endothelial growth factor
To evaluate the potential actions of vascular endothelial growth factor (VEGF) on capillary permeabilityand drug transport, tumorigenic human glioma cell lines were developed that expressed different levels of...
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Fibronectin is chemotactic for CT 26 colon carcinoma cells: sub-lines selected for increased chemotaxis to fibronectin display decreased tumorigenicity and lung colonization
CT 26 murine colon carcinoma cells demonstrated directional migration (chemotaxis) in response to fibronectin (FN). Sub-lines were derived by positive and negative selection to FN across Transwell filters of 8...
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An ultra-metastatic model of human colon cancer in nude mice
An ultra-high metastatic model of human colon cancer was developed in order to represent highly malignant patient disease for which there is no current model. Surgical orthotopic implantation (SOI) of a histol...
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Differential expression of RAB5A in human lung adenocarcinoma cells with different metastasis potential
For the sake of better understanding the molecular mechanism of neoplasia, we have used the mRNA differential display technique to analyze two human lung adenocarcinoma cell lines, AGZY83-a and Anip973. Anip97...
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A modified Boyden chamber assay for tumor cell transendothelial migration in vitro
We have developed a modified Boyden chamber system for assessing tumor cell transmigration across endothelial monolayer in vitro. This radiometric-based method allows us to take into account the cells which ha...
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Chemokines induce the cellular migration of MCF-7 human breast carcinoma cells: Subpopulations of tumour cells display positive and negative chemotaxis and differential in vivo growth potentials
We previously reported that chemotactic cytokines (chemokines) induce the directional migration of cells derived from the breast carcinoma cell line MCF-7 in vitro, however it was apparent that only a small pe...
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Nitric oxide (NO), methylation and TIMP-1 expression in BL6 melanoma cells transfected with MHC class I genes
We have previously found that transfection of BL6-8 melanoma cells with the H-2K, but not H-2D/L genes resulted in loss of their metastatic ability that was associated with decrease in their invasiveness and u...
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Gastritis cystica polyposa associated with a gastric stump carcinoma, with special reference to cell kinetics and p53 gene aberrations
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Reversal effects of nomegestrol acetate on multidrug resistance in adriamycin-resistant MCF7 breast cancer cell line
Chemotherapy is important in the systematic treatment of breast cancer. To enhance the response of tumours to chemotherapy, attention has been focused on agents to reverse multidrug resistance (MDR) and on the...
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Article
Anterior approach to the second thoracic vertebral body for surgical treatment (vertebrectomy, bone grafting, and titanium alloy plate fixation)
The surgical approach to the second thoracic vertebral body is difficult from the anterior side. A 38-year-old woman suffering from plasmacytoma in the second thoracic vertebra showed paraplegia for 2 weeks p...
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Implications of adrenomedullin expression in the invasion of squamous cell carcinoma of the uterine cervix
