4,183 Result(s)

Article

Correction: MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma

Qin Tang, Wan Li, **ang** Zheng, Liwen Ren… in Signal Transduction and Targeted Therapy (2024)

Article

Carbon-ion radiotherapy alone vs. standard dose photon radiation with carbon-ion radiotherapy boost for high-grade gliomas: a retrospective study

This study aimed to compare the survival outcome and side effects in patients with primary high-grade glioma (HGG) who received carbon ion radiotherapy (CIRT) alone or as a boost strategy after photon radiatio...

**aoJun Li, YanShan Zhang, YanCheng Ye, SuQing Tian, TingChao Hu, HongYu Chai… in BMC Cancer (2024)

Article

Pegylated recombinant human granulocyte colony-stimulating factor for primary prophylaxis of neutropenia in patients with cervical cancer receiving concurrent chemoradiotherapy: a prospective study

This study aimed to investigate the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) for primary prophylaxis of neutropenia in patients with cervical cance...

**g You, Yidi Yuan, **aoxuan Gu, Weihu Wang, **aofan Li in BMC Cancer (2024)

Article

Nomogram for predicting the probability of rectal anastomotic re-leakage after stoma closure: a retrospective study

In this study, we aimed to identify the risk factors in patients with rectal anastomotic re-leakage and develop a prediction model to predict the probability of rectal anastomotic re-leakage after stoma closure.

Yuegang Li, Gang Hu, **zhu Zhang, Wenlong Qiu, Shiwen Mei, **shan Wang… in BMC Cancer (2024)

Article

Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether pyroptosis can be a death form of MC remains unknown. Proteasom...

Zhan-Li Chen, Chen **e, Wei Zeng, Rui-Qi Huang… in Signal Transduction and Targeted Therapy (2024)

Article

eHSP90α in front-line therapy in EGFR exon 19 deletion and 21 Leu858Arg mutations in advanced lung adenocarcinoma

Extracellular heat shock protein 90 AA1(eHSP90α) is intricately linked to tumor progression and prognosis. This study aimed to investigate the difference in the value of eHSP90α in post-treatment response asse...

Yingzhen Bian, Haizhou Liu, **glei Huang, Zhaorong Feng, Yanyan Lin… in BMC Cancer (2024)

Article

Correction: Apatinib combined with temozolomide in diffuse midline glioma: a novel and effective therapy

Yu-An Li, Chuan Zhao, **g-**g Ge, Cheng Li, Feng-Jun Xue, Shao-Pei Qi… in BMC Cancer (2024)

Article

Survival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study

Most gastrointestinal stromal tumors (GISTs) harbor c-KIT or PDGFRA mutations. Administration of tyrosine kinase inhibitors (TKIs) has significantly improved the survival of patients with GISTs. We aimed to evalu...

Hui-Jen Tsai, Yan-Shen Shan, Ching-Yao Yang, Chin-Fu Hsiao, Chung-Hsin Tsai… in BMC Cancer (2024)

Article

Genetic constraint at single amino acid resolution in protein domains improves missense variant prioritisation and gene discovery

One of the major hurdles in clinical genetics is interpreting the clinical consequences associated with germline missense variants in humans. Recent significant advances have leveraged natural variation observ...

**aolei Zhang, Pantazis I. Theotokis, Nicholas Li, Caroline F. Wright… in Genome Medicine (2024)

Article

Selective anti-tumor activity of glutathione-responsive abasic site trap** agent in anaplastic thyroid carcinoma

Anaplastic thyroid carcinoma (ATC) is a rare but highly aggressive thyroid cancer with poor prognosis. Killing cancer cells by inducing DNA damage or blockage of DNA repair is a promising strategy for chemothe...

**yan Chai, Mengxue Su, Ruiguo Zhang, Ning Li, Yuanyuan Jia, Wei Zheng… in BMC Cancer (2024)

Article

Prognostic and clinicopathological significance of tertiary lymphoid structure in non-small cell lung cancer: a systematic review and meta-analysis

Non-small cell lung cancer (NSCLC) is the primary reason for cancer-related deaths globally. Tertiary lymphoid structure (TLS) is an organized collection of immune cells acquired in non-physiological, non-lymp...

Luyuan Ma, Rongyang Li, **aomeng Liu, Wenhao Yu, Zhanpeng Tang, Yi Shen… in BMC Cancer (2024)

Article

KK-LC-1, a biomarker for prognosis of immunotherapy for primary liver cancer

There is mounting evidence that patients with liver cancer can benefit from Immune checkpoint inhibitors. However, due to the high cost and low efficacy, we aimed to explore new biomarkers for predicting the e...

Sihui Zhu, Yuncheng **, Mingzhen Zhou, Lin Li, Xueru Song, **nyu Su… in BMC Cancer (2024)

Article

Establishment and characterization of a novel multidrug-resistant pancreatic ductal adenocarcinoma cell line, PDAC-X1

Drug resistance remains a significant challenge in the treatment of pancreatic cancer. The development of drug-resistant cell lines is crucial to understanding the underlying mechanisms of resistance and devel...

Cheng Yu, Yuanhui Su, **n Miao, Changpeng Chai, Huan Tang, Lu Li, Jianfeng Yi… in BMC Cancer (2024)

Article

Integrating lipid metabolite analysis with MRI-based transformer and radiomics for early and late stage prediction of oral squamous cell carcinoma

Oral Squamous Cell Carcinoma (OSCC) presents significant diagnostic challenges in its early and late stages. This study aims to utilize preoperative MRI and biochemical indicators of OSCC patients to predict t...

Wen Li, Yang Li, Shiyu Gao, Nengwen Huang, Ikuho Kojima, Taro Kusama… in BMC Cancer (2024)

Article

Early change of plasma Epstein-Barr virus DNA load and the viral lytic genome level could positively predict clinical outcome in recurrent or metastatic nasopharyngeal carcinoma receiving anti-programmed cell death 1 monotherapy

Patients with recurrent or metastatic nasopharyngeal carcinoma (RM-NPC) have proven benefit from anti-programmed cell death 1 (anti-PD-1) monotherapy. Here, we retrospectively analyze the association of plasma...

Shaoyan Lin, Huaqiang Zhou, Gang Chen, **hui Xue, Qianwen Liu, Jianing Li… in BMC Cancer (2024)

Article

Combination of MRI-based prediction and CRISPR/Cas12a-based detection for IDH genoty** in glioma

Early identification of IDH mutation status is of great significance in clinical therapeutic decision-making in the treatment of glioma. We demonstrate a technological solution to improve the accuracy and reli...

Donghu Yu, Qisheng Zhong, Yilei **ao, Zhebin Feng, Feng Tang… in npj Precision Oncology (2024)

Article

B cell lymphoma 6 promotes hepatocellular carcinoma progression by inhibiting tumor infiltrating CD4⁺T cell cytotoxicity through ESM1

Immunotherapy exhibited potential effects for advanced hepatocellular carcinoma, unfortunately, the clinical benefits are often countered by cancer adaptive immune suppressive response. Uncovering the mechanis...

Jiatao Li, Juan Feng, Ziyong Li, Yuanli Ni, Limei Liu, **a Lei… in npj Precision Oncology (2024)