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  1. No Access

    Article

    In vivo AAV–SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy

    Natural killer (NK) cells have clinical potential against cancer; however, multiple limitations hinder the success of NK cell therapy. Here, we performed unbiased functional map** of tumor-infiltrating NK (T...

    Lei Peng, Paul A. Renauer, Giacomo Sferruzza, Luojia Yang… in Nature Biotechnology (2024)

  2. Article

    Open Access

    Identification and validation of RNA-binding protein SLC3A2 regulates melanocyte ferroptosis in vitiligo by integrated analysis of single-cell and bulk RNA-sequencing

    The pathogenesis of vitiligo remains unclear. The genes encoding vitiligo-related RNA-binding proteins (RBPs) and their underlying pathogenic mechanism have not been determined.

    **gzhan Zhang, Fang **ang, Yuan Ding, Wen Hu, Hongjuan Wang… in BMC Genomics (2024)

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  3. Article

    Open Access

    Inhibition of PDGFRβ alleviates endothelial cell apoptotic injury caused by DRP-1 overexpression and mitochondria fusion failure after mitophagy

    Kawasaki disease (KD), described as “mucocutaneous lymph node syndrome”, affects infants and toddlers. Patients with KD suffer from an inflammatory cascade leading to vasculitis with a predilection for coronary a...

    **aohong An, **ao Ma, Heng Liu, **g Song, Tiange Wei… in Cell Death & Disease (2023)

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  4. No Access

    Chapter

    Functional Linear Regression for Partially Observed Functional Data

    In functional linear regression model, many methods have been proposed and studied to estimate the slope function while the functional predictor was observed in the entire domain. However, works on functional ...

    Yafei Wang, Tingyu Lai, Bei Jiang… in Advances and Innovations in Statistics and… (2022)

  5. No Access

    Article

    Nr1d1 affects autophagy in the skeletal muscles of juvenile Nile tilapia by regulating the rhythmic expression of autophagy-related genes

    Autophagy is an important evolutionary conserved process in eukaryotic organisms for the turnover of intracellular substances. Recent studies revealed that autophagy displays circadian rhythms in mice and zebr...

    ** Wu, Jia Cheng, Lin Chen, **g **ang, Yaxiong Pan… in Fish Physiology and Biochemistry (2020)