68 Result(s)

Article

Biofilm-producing ability of methicillin-resistant Staphylococcus aureus clinically isolated in China

Staphylococcus aureus, a commensal bacterium, colonizes the skin and mucous membranes of approximately 30% of the human population. Apart from conventional resistance mechanisms, one of the pathogenic features of...

**gyi Yu, Weihua Han, Yanlei Xu, Li Shen, Huilin Zhao, Jiao Zhang… in BMC Microbiology (2024)

Article

Cheer for me: effect of non-player character audience feedback on older adult users of virtual reality exergames

The presence of an audience and its feedback could affect people’s performance and experience during an event, especially related to sports such as tennis or boxing. Similarly, in videogames, players’ gameplay...

Kangyou Yu, Shaoyue Wen, Wenge Xu, Maurizio Caon, Nilufar Baghaei… in Virtual Reality (2023)

Article

Young SINEs in pig genomes impact gene regulation, genetic diversity, and complex traits

Transposable elements (TEs) are a major source of genetic polymorphisms and play a role in chromatin architecture, gene regulatory networks, and genomic evolution. However, their functional role in pigs and co...

Pengju Zhao, Lihong Gu, Yahui Gao, Zhangyuan Pan, Lei Liu… in Communications Biology (2023)

Article

Effect of Sivelestat in the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis

The efficacy of neutrophil elastase inhibitor sivelestat in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remains controversial. A systematic review and meta-analysis ...

Qiongli Ding, Yi Wang, Chunbo Yang, Dilireba Tuerxun… in Intensive Care Research (2023)

Article

Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques

Omicron spike (S) encoding vaccines as boosters, are a potential strategy to improve COVID-19 vaccine efficacy against Omicron. Here, macaques (mostly females) previously immunized with Ad26.COV2.S, are booste...

Laura Solforosi, Lea M. M. Costes, Jeroen T. B. M. Tolboom… in Nature Communications (2023)

Article

Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

Etsuro Nanishi, Francesco Borriello, Hyuk-Soo Seo, Timothy R. O’Meara… in npj Vaccines (2023)

Article

Clinical Utility of the Sivelestat for the Treatment of ALI/ARDS: Moving on in the Controversy?

Acute respiratory distress syndrome (ARDS) is a serious condition that can arise following direct or indirect acute lung injury (ALI). It is heterogeneous and has a high mortality rate. Supportive care is the ...

Qiongli Ding, Yi Wang, Chunbo Yang, **ang Li, **angyou Yu in Intensive Care Research (2023)

Article

Immunogenicity and protective efficacy of GBP510/AS03 vaccine against SARS-CoV-2 delta challenge in rhesus macaques

Despite the availability of several effective SARS-CoV-2 vaccines, additional vaccines will be required for optimal global vaccination. In this study, we investigate the immunogenicity and protective efficacy ...

Catherine Jacob-Dolan, **gyou Yu, Katherine McMahan, Victoria Giffin… in npj Vaccines (2023)

Article

Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

Development of SARS-CoV-2 vaccines that protect vulnerable populations is a public health priority. Here, we took a systematic and iterative approach by testing several adjuvants and SARS-CoV-2 antigens to ide...

Etsuro Nanishi, Francesco Borriello, Hyuk-Soo Seo, Timothy R. O’Meara… in npj Vaccines (2023)

Article

Circulating expression and clinical significance of LncRNA ANRIL in diabetic kidney disease

Long noncoding RNA ANRIL has been found to be involved in the pathogenesis of diabetic kidney disease (DKD) and is expected to be a new target for prevention of DKD. However, the circulating expression and cli...

Yanting Zhu, Lixia Dai, **angyou Yu, **ntian Chen… in Molecular Biology Reports (2022)

Article

Immunogenicity and protective efficacy of a rhesus adenoviral vaccine targeting conserved COVID-19 replication transcription complex

The COVID-19 pandemic marks the third coronavirus pandemic this century (SARS-CoV-1, MERS, SARS-CoV-2), emphasizing the need to identify and evaluate conserved immunogens for a pan-sarbecovirus vaccine. Here w...

Gabriel Dagotto, John D. Ventura, David R. Martinez, Tochi Anioke… in npj Vaccines (2022)

Article

Dietary supplementation of Macleaya cordata extract and Bacillus in combination improve laying performance by regulating reproductive hormones, intestinal microbiota and barrier function of laying hens

This study aimed to investigate whether the combination of Macleaya cordata extract (MCE) and Bacillus could improve the laying performance and health of laying hens better.

Fei Wang, Peng Zou, Shujie Xu, Qi Wang… in Journal of Animal Science and Biotechnology (2022)

Article

mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant

The SARS-CoV-2 Omicron variant evades vaccine-induced immunity. While a booster dose of ancestral mRNA vaccines effectively elicits neutralizing antibodies against variants, its efficacy against Omicron in old...

Etsuro Nanishi, Marisa E. McGrath, Timothy R. O’Meara… in Communications Biology (2022)

Article

mRNA vaccines induce rapid antibody responses in mice

mRNA vaccines can be developed and produced quickly, making them prime candidates for immediate outbreak responses. Furthermore, clinical trials have demonstrated rapid protection following mRNA vaccination. T...

Makda S. Gebre, Susanne Rauch, Nicole Roth, Janina Gergen, **gyou Yu… in npj Vaccines (2022)

Article

Characteristics of lymphocyte subsets and cytokine profiles of patients with COVID-19

Abnormalities of lymphocyte subsets and cytokine profiles have been observed in most patients with coronavirus disease (COVID-19). Here, we explore the role of lymphocyte subsets and cytokines on hospital admi...

Pengfei Pan, **nxin Du, Qilong Zhou, Yong Cui, **aochun Deng, Chao Liu… in Virology Journal (2022)

Article

Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron

The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 spike protein¹. Ce...

**yan Liu, Abishek Chandrashekar, Daniel Sellers, Julia Barrett… in Nature (2022)