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Article
Open AccessAssociation between maximum norepinephrine dosage and mortality risk in neonates with septic shock
The high-dose usage of norepinephrine is thought to cause high mortality in patients with septic shock. This study aims to explores the correlation between the maximum norepinephrine (NE) dosage (MND) and mort...
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Article
A review of heterocyclic aromatic amines in cooked meat: generation pathways and mitigation mechanism by natural exogenous additives
Heterocyclic aromatic amines (HAAs) are a class of carcinogenic substances formed during thermal processing of meat foods. Natural exogenous additives have been widely used in the food processing industry due ...
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Article
Effects of centrifugation treatment before electroporation on gene editing in pig embryos
Genetic mosaicism, characterized by multiple genotypes within an individual, is considered an obstacle to CRISPR/Cas9 genome editing in animal models. Despite the various strategies for minimizing mosaic mutat...
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Article
Open AccessGLUT1 promotes cell proliferation via binds and stabilizes phosphorylated EGFR in lung adenocarcinoma
While previous studies have primarily focused on Glucose transporter type 1 (GLUT1) related glucose metabolism signaling, we aim to discover if GLUT1 promotes tumor progression through a non-metabolic pathway.
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Article
Inhibition of undesirable flavor compounds and lipid oxidation in infant nutrition powder using kiwifruit powder, orange powder and quinoa flour-based formulations
Flavor plays an essential role in the sensory and consumer acceptance of complementary food products for infants and young children. To improve the quality of infant complementary food nutrition powder, the vo...
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Article
Open AccessThe OGT–c-Myc–PDK2 axis rewires the TCA cycle and promotes colorectal tumor growth
Deregulated glucose metabolism termed the “Warburg effect” is a fundamental feature of cancers, including the colorectal cancer. This is typically characterized with an increased rate of glycolysis, and a conc...
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Article
Organic ligand nanoarchitectonics for BiVO4 photoanodes surface passivation and cocatalyst grafting
Bismuth vanadate (BiVO4) is a promising photoanode material for efficient photoelectrochemical (PEC) water splitting, whereas its performance is inhibited by detrimental surface states. To solve the problem, here...
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Article
Effect of low-cost mussel-inspired poly(catechol/polyamine) modification of waste brick powder followed by grafting of epoxy elastomers on natural rubber composites
The aim of this study is to explore a method for modifying waste brick powder (WBP) in order to reapply it to rubber products for effective resource recycling. Firstly, we use the auto polymerization of catech...
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Article
Evaluation of culture methods and chemical reagent combinations on CRISPR/Cas9 gene editing systems by lipofection in pig zygotes
The delivery of CRISPR/Cas ribonucleoprotein (RNP) complexes is gaining attention owing to its high cleavage efficiency and reduced off-target effects. Although RNPs can be delivered into porcine zygotes via e...
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Article
Programmed cell death-1-modified pig developed using electroporation-mediated gene editing for in vitro fertilized zygotes
Programmed cell death-1 (PD-1) is an immunoinhibitory receptor required to suppress inappropriate immune responses such as autoimmunity. Immune checkpoint antibodies that augment the PD-1 pathway lead to immun...
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Article
Prognostic value of RRM1 and its effect on chemoresistance in pancreatic cancer
Pancreatic cancer (PC) remains a lethal disease, and gemcitabine resistance is prevalent. However, the biomarkers suggestive of gemcitabine resistance remain unclear.
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Article
Open AccessA novel EIF3C-related CD8+ T-cell signature in predicting prognosis and immunotherapy response of nasopharyngeal carcinoma
At present, dysfunctional CD8+ T-cells in the nasopharyngeal carcinoma (NPC) tumor immune microenvironment (TIME) have caused unsatisfactory immunotherapeutic effects, such as a low response rate of anti-PD-L1 th...
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Article
Screening and Identification of a Strain with Protease and Phytase Activities and Its Application in Soybean Meal Fermentation
The aims of the study were to degrade the anti-nutritional factors (ANFs) such as phytic acid, glycinin, and β-conglycinin and improve the values of soybean meal (SBM). Firstly, in this study, a strain PY-4B w...
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Article
Open AccessLong non-coding RNAs and their potential function in response to postharvest senescence of Sparassis latifolia during cold storage
Long non-coding RNAs (lncRNAs) have been shown to play crucial roles in response to aging processes. However, how lncRNAs regulate postharvest senescence of Sparassis latifolia (S. latifolia) with oriented polypr...
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Chapter and Conference Paper
An Empirical Study on the Urgent Self-admitted Technical Debt
Technical Debt (TD) refers to the phenomenon of taking shortcuts to achieve short-term gains at the cost of higher maintenance effort in the future. While Self-Admitted Technical Debt (SATD) is the TD that has...
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Article
Open Access18F-FDG PET/CT-based deep learning radiomics predicts 5-years disease-free survival after failure to achieve pathologic complete response to neoadjuvant chemotherapy in breast cancer
This study aimed to assess whether a combined model incorporating radiomic and depth features extracted from PET/CT can predict disease-free survival (DFS) in patients who failed to achieve pathologic complete...
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Article
Study of anode self-humidifying gas diffusion layer
Hydrogen is oxidized into H+ and e− on the anode side of fuel cell. H+ is transported from anode to cathode of fuel cell in the form of H3+O. When fuel cell is running under low humidity, the relatively small wat...
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Article
Association of flooding exposure with cause-specific mortality in North Carolina, United States
Flooding could adversely impact human health, but its association with different causes of mortality remains unclear. Here we employed a two-stage time series design, utilizing data from 446,807 deaths that oc...
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Article
Open AccessCorrection: The trade-off of post-mastectomy radiotherapy usage for the breast cancer patients aged 70 years or older: a study based on SEER database
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Article
Clinical efficacy of prostate PI-RADS V2.1 score combined with serum PSA-related indicators in the detection of gray zone prostate cancer
The purpose of this study is to improve the diagnostic accuracy of gray zone prostate cancer evaluation by combining the prostate imaging report and data system version 2.1 (PI-RADS V2.1) score with serum pros...
