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122 Result(s)
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Article
Open AccessLongSAGE profiling of nine human embryonic stem cell lines
To facilitate discovery of novel human embryonic stem cell (ESC) transcripts, we generated 2.5 million LongSAGE tags from 9 human ESC lines. Analysis of this data revealed that ESCs express proportionately mor...
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Article
Open AccessA systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE)
The embryonic definitive endoderm (DE) gives rise to organs of the gastrointestinal and respiratory tract including the liver, pancreas and epithelia of the lung and colon. Understanding how DE progenitor cell...
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Article
Open AccessIdentification of a set of genes showing regionally enriched expression in the mouse brain
The Pleiades Promoter Project aims to improve gene therapy by designing human mini-promoters (< 4 kb) that drive gene expression in specific brain regions or cell-types of therapeutic interest. Our goal was to...
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Chapter and Conference Paper
An Asynchronous Parallelized and Scalable Image Resampling Algorithm with Parallel I/O
Image resampling which is frequently used in remote sensing processing procedure is a time-consuming task. Parallel computing is an effective way to speed up. However, recent parallel image resampling algorith...
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Article
Open AccessIdentification of genes expressed in the hermaphrodite germ line of C. elegans using SAGE
Germ cells must progress through elaborate developmental stages from an undifferentiated germ cell to a fully differentiated gamete. Some of these stages include exiting mitosis and entering meiosis, progressi...
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Article
Open AccessMutational evolution in a lobular breast tumour profiled at single nucleotide resolution
Next-generation sequencing approaches have been used to investigate the genomes and transcriptomes of an oestrogen-receptor-α-positive metastatic lobular breast cancer from a patient — rather than from a cell ...
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Article
Control of neotectonic movement on hydrocarbon accumulation in the Kuqa Foreland Basin, west China
Neotectonic movement refers to the tectonic movement that has happened since the Cenozoic, which is the latest movement. It has the most important influence on the basins in west China, especially on the hydro...
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Article
Open AccessIsolation and Identification of Black Yeasts by Enrichment on Atmospheres of Monoaromatic Hydrocarbons
Black yeast members of the Herpotrichiellaceae present a complex ecological behavior: They are often isolated from rather extreme environments polluted with aromatic hydrocarbons, while they are also regularly in...
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Article
Open AccessGenomic analysis of a rare human tumor
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Article
Open AccessEvolution of an adenocarcinoma in response to selection by targeted kinase inhibitors
Adenocarcinomas of the tongue are rare and represent the minority (20 to 25%) of salivary gland tumors affecting the tongue. We investigated the utility of massively parallel sequencing to characterize an aden...
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Article
Sensitivity analysis of CO2 sequestration in saline aquifers
Carbon capture and storage (CCS) technology has been considered as an important method for reducing greenhouse gas emissions and for mitigating global climate change. Three primary options are being considered...
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Article
Personalized oncogenomics
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Article
Open AccessFrequent mutation of histone-modifying genes in non-Hodgkin lymphoma
Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched normal DNA from 13 DLBCL cases and one FL case to i...
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Article
Open AccessiAssembler: a package for de novo assembly of Roche-454/Sanger transcriptome sequences
Expressed Sequence Tags (ESTs) have played significant roles in gene discovery and gene functional analysis, especially for non-model organisms. For organisms with no full genome sequences available, ESTs are ...
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Article
Open AccessSorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
β-site APP cleaving enzyme 1 (BACE1) cleaves β-amyloid precursor protein (APP) to initiate the production of β-amyloid (Aβ), the prime culprit in Alzheimer’s disease (AD). Dysregulation of the intracellular tr...
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Article
Coalbed methane genesis, occurrence and accumulation in China
Coalbed methane (CBM) is an important type of unconventional gas. Commercial development of CBM in America has been very successful since the 1980s. The CBM industry in Australia and Canada has developed rapid...
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Article
Open AccessBuilding detection from urban SAR image using building characteristics and contextual information
With the urgent demand on urban synthetic aperture radar (SAR) image interpretation, this article deals with detecting buildings from a single high-resolution SAR image. Based on our previous work in building ...
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Article
Open AccessDraft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins, a major forest pest
The mountain pine beetle, Dendroctonus ponderosae Hopkins, is the most serious insect pest of western North American pine forests. A recent outbreak destroyed more than 15 million hectares of pine forests, with m...
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Article
Open AccessPurifying synthetic high-strength wastewater by microalgae chlorella vulgaris under various light emitting diode wavelengths and intensities
The high-strength wastewater is now well known as a threat to the natural water since it is highly possible to arouse water eutrophication or algal blooms. The effects of various light emitting diode wavelengt...
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Article
Open AccessBarnacle: detecting and characterizing tandem duplications and fusions in transcriptome assemblies
Chimeric transcripts, including partial and internal tandem duplications (PTDs, ITDs) and gene fusions, are important in the detection, prognosis, and treatment of human cancers.