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Article
Open AccessLife’s essential 8, genetic susceptibility, and risk of inflammatory bowel diseases: a population-based cohort study
Evidence has shown that the individual metrics in Life’s Essential 8 (LE8), an updated cardiovascular health (CVH) concept proposed by the American Heart Association, play a role in the development of inflamma...
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Article
Open AccessComposition and diversity of soil microbial communities change by introducing Phallus impudicus into a Gastrodia elata Bl.-based soil
The Gastrodia elata Bl. is an orchid, and its growth demands the presence of Armillaria species. The strong competitiveness of Armillaria species has always been a concern of major threat to other soil organisms,...
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Article
Open AccessDetection of atherosclerotic plaques with HDL-like porphyrin nanoparticles using an intravascular dual-modality optical coherence tomography and fluorescence system
Atherosclerosis is the build-up of fatty plaques within blood vessel walls, which can occlude the vessels and cause strokes or heart attacks. It gives rise to both structural and biomolecular changes in the ve...
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Article
Open AccessDTP: learning to estimate full-body pose in real-time from sparse VR sensor measurements
For virtual reality (VR) applications, estimating full-body pose in real-time is becoming increasingly popular. Previous works have reconstructed full-body motion in real time from an HTC VIVE headset and five...
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Article
Open AccessFeedback loop between hypoxia and energy metabolic reprogramming aggravates the radioresistance of cancer cells
Radiotherapy is one of the mainstream approaches for cancer treatment, although the clinical outcomes are limited due to the radioresistance of tumor cells. Hypoxia and metabolic reprogramming are the hallmark...
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Article
Open AccessInsulin resistance, coronary artery lesion complexity and adverse cardiovascular outcomes in patients with acute coronary syndrome
Insulin resistance (IR) is linked to both the complexity of coronary artery lesions and the prognosis of acute coronary syndrome (ACS). However, the precise extent of this correlation and its impact on adverse...
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Article
Open AccessConstraining on the non-standard cosmological models combining the observations of high-redshift quasars and BAO
In this work, we studied four types of cosmological models with different mechanisms driving the accelerated expansion of the universe, include Braneworld models, Chaplygin Gas models, Emergent Dark Energy mod...
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Article
Open AccessEfficacy and safety of fibrin sealant application in patients undergoing thyroidectomy: a systematic review and meta-analysis
Various studies have focused on the application of fibrin sealants (FS) in thyroid surgery. Utilizing a meta-analysis, this systematic review analyzed the findings of recent randomized controlled trials on the...
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Article
Open AccessNetwork pharmacology, computational biology integrated surface plasmon resonance technology reveals the mechanism of ellagic acid against rotavirus
The target and mechanism of ellagic acid (EA) against rotavirus (RV) were investigated by network pharmacology, computational biology, and surface plasmon resonance verification. The target of EA was obtained ...
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Article
Open AccessImmune modulation in malignant pleural effusion: from microenvironment to therapeutic implications
Immune microenvironment and immunotherapy have become the focus and frontier of tumor research, and the immune checkpoint inhibitors has provided novel strategies for tumor treatment. Malignant pleural effusio...
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Article
Open AccessEffects of irrigation scheduling on the yield and irrigation water productivity of cucumber in coconut coir culture
Optimum irrigation scheduling is important for ensuring high yield and water productivity in substrate-cultivated vegetables and is determined based on information such as substrate water content, meteorologic...
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Article
Open AccessInnate immune and proinflammatory signals activate the Hippo pathway via a Tak1-STRIPAK-Tao axis
The Hippo pathway controls developmental, homeostatic and regenerative tissue growth, and is frequently dysregulated in various diseases. Although this pathway can be activated by innate immune/inflammatory st...
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Article
Open AccessUnconventional polarization fatigue in van der Waals layered ferroelectric ionic conductor CuInP2S6
Recent progress in two-dimensional ferroelectrics greatly expands the versatility and tunability in van der Waals heterostructure based electronics. However, the switching endurance issue that widely plagues c...
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Article
Open AccessNeoadjuvant PD-1/PD-L1 combined with CTLA-4 inhibitors for solid malignancies: a systematic review and meta-analysis
The effectiveness and safety of neoadjuvant PD-1/PD-L1 inhibitors combined with CTLA-4 inhibitors is controversial. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of PD-1/PD...
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Article
Open AccessThe triglyceride-glucose index predicts 1-year major adverse cardiovascular events in end-stage renal disease patients with coronary artery disease
The triglyceride-glucose (TyG) index has been suggested as a dependable indicator for predicting major adverse cardiovascular events (MACE) in individuals with cardiovascular conditions. Nevertheless, there is...
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Article
Open AccessPredictive value of the stress hyperglycemia ratio in dialysis patients with acute coronary syndrome: insights from a multi-center observational study
Various studies have indicated that stress hyperglycemia ratio (SHR) can reflect true acute hyperglycemic status and is associated with poor outcomes in patients with acute coronary syndrome (ACS). However, da...
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Article
Open AccessTriglyceride-glucose index is associated with recurrent revascularization in patients with type 2 diabetes mellitus after percutaneous coronary intervention
The Triglyceride-glucose (TyG) index, as a surrogate marker of insulin resistance, is independently associated with the severity of coronary artery lesions and the prognosis of coronary heart disease. The inve...
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Article
Open AccessAssociation of triglyceride–glucose index with coronary severity and mortality in patients on dialysis with coronary artery disease
The triglyceride–glucose (TyG) index is validated as a reliable biomarker of insulin resistance and an independent predictor of cardiovascular prognosis. However, the prognostic value of the TyG index in patie...
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Article
Open AccessA nomogram for predicting severe myelosuppression in small cell lung cancer patients following the first-line chemotherapy
This study aimed at establishing and validating a nomogram to predict the probability of severe myelosuppression in small cell lung cancer (SCLC) patients following the first-line chemotherapy. A total of 179 ...
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Article
Open AccessMyoglobin-loaded gadolinium nanotexaphyrins for oxygen synergy and imaging-guided radiosensitization therapy
Gadolinium (Gd3+)-coordinated texaphyrin (Gd-Tex) is a promising radiosensitizer that entered clinical trials, but temporarily fails largely due to insufficient radiosensitization efficacy. Little attention has b...
