40 Result(s)
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Article
Species selective concentration and determination of nano-selenium and inorganic selenium species in environmental waters by micropore membrane filtration and ICP-MS
Accurate quantification of nano-selenium (nSe) and other ionic Se species in aquatic environments is a prerequisite for reliable estimation of their potential hazards. In this study, a micropore membrane filtr...
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A strain of Vibrio alginolyticus isolated from Azumapecten farreri and its pathogenic mechanism using CRISPR-Cas9 technology
Scallops have become an important aquaculture species in China because they contain high-quality protein, and scallops are important health food that combines multiple effects and high economic benefits. Howev...
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Article
Targeting androgen receptor phase separation to overcome antiandrogen resistance
Patients with castration-resistant prostate cancer inevitably acquire resistance to antiandrogen therapies in part because of androgen receptor (AR) mutations or splice variants enabling restored AR signaling....
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LncRNA UCA1 epigenetically suppresses APAF1 expression to mediate the protective effect of sevoflurane against myocardial ischemia–reperfusion injury
Myocardial ischemia–reperfusion injury (MI/RI) is a leading cause of death globally. Whereas some long noncoding RNAs (lncRNAs) are known to participate in the progression of MI/RI, the role of urothelial carc...
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Article
Open AccessMFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis
Intervertebral disc degeneration (IVDD) is a chronic age-related degenerative disease accompanied by complex pathophysiological mechanisms. Increasing evidence indicates that NLRP3 inflammasome mediated pyropt...
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Article
Open AccessComparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities
Studies of radiation interaction with tumor cells often take apoptosis as the desired results. However, mitotic catastrophe and senescence are also promoted by clinically relevant doses of radiation. Furthermo...
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Article
Coexistence of endonuclease and exonuclease activities in a novel RecJ from Bacillus cereus
All RecJ proteins are known to date only perform exonuclease activity. The present study reports that a novel RecJ protein obtained from Bacillus cereus isolated from marine sediments has both endonuclease and ex...
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Article
Is the 0.2%-Strain-Offset Approach Appropriate for Calculating the Yield Stress of Cortical Bone?
The 0.2% strain offset approach is mostly used to calculate the yield stress and serves as an efficient method for cross-lab comparisons of measured material properties. However, it is difficult to accurately ...
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Article
Open AccessSTING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway
Damaged deoxyribonucleic acid (DNA) is a primary pathologic factor for osteoarthritis (OA); however, the mechanism by which DNA damage drives OA is unclear. Previous research demonstrated that the cyclic GMP-A...
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Article
Open AccessAn efficient autometallography approach to localize lead at ultra-structural levels of cultured cells
Understanding the precise intracellular localization of lead (Pb) is a key in deciphering processes in Pb-induced toxicology. However, it is a great challenge to trace Pb in vitro, especially in cultured cells. W...
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Article
Applications of WaterControl to TOCSY and COSY experiments
WaterControl is a solvent suppression method based on WATERGATE and PGSTE and is very efficient in selectively reducing the solvent signal in 1D pulse-acquire and 2D NOESY of protein solutions. In this study, ...
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Article
Comparative analyses of chloroplast genomes from 13 Lagerstroemia (Lythraceae) species: identification of highly divergent regions and inference of phylogenetic relationships
Seven divergence hotspots as plastid markers for DNA barcoding was selected, and the phylogeny of 13 Lagerstroemia species based on the cp genome data was reconstructed within Myrtales.
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Article
Comparative profiling of roots small RNA expression and corresponding gene ontology and pathway analyses for low- and high-cadmium–accumulating genotypes of wheat in response to cadmium stress
MicroRNAs (miRNAs) participate in multiple biological processes in plant. Cd accumulation ability differs among varieties in wheat, but little is known about miRNAs and their function in Cd accumulation of whe...
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Comparative analysis of root transcriptome profiles between low- and high-cadmium-accumulating genotypes of wheat in response to cadmium stress
Wheat, one of the most broadly cultivated and consumed food crops worldwide, can accumulate high Cd contents in their edible parts, which poses a major hazard to human health. Cd accumulation ability differs a...
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Article
Neuroinflammation in acute hepatic encephalopathy rats: imaging and therapeutic effectiveness evaluation using 11C-PK11195 and 18F-DPA-714 micro-positron emission tomography
Neuroinflammation has an important influence in pathogenesis of acute hepatic encephalopathy (AHE). 11C-PK11195 and 18F-DPA-714 targeted to translocator protein (TSPO) have potential application in positron emiss...
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Article
Open AccessTFEB, a potential therapeutic target for osteoarthritis via autophagy regulation
The blockage of autophagic flux in chondrocytes has been considered as a major reason for the excessive cellular apoptosis and senescence in osteoarthritis (OA) development; however, the molecular mechanism an...
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Article
Open AccessTrehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development
Oxidative stress-related apoptosis and autophagy play crucial roles in the development of osteoarthritis (OA), a progressive cartilage degenerative disease with multifactorial etiologies. Here, we determined a...
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Article
NOESY-WaterControl: a new NOESY sequence for the observation of under-water protein resonances
Highly selective and efficient water signal suppression is indispensable in biomolecular 2D nuclear Overhauser effect spectroscopy (NOESY) experiments. However, the application of conventional water suppressio...
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Article
Interaction mechanism of pepsin with a natural inhibitor gastrodin studied by spectroscopic methods and molecular docking
The interaction of gastrodin with pepsin has been investigated by enzyme activity assay, fluorescence, UV–Visible, circular dichroism spectra, and molecular docking. The pepsin activity results suggest that ga...
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Article
Small-molecule WNK inhibition regulates cardiovascular and renal function
A selective inhibitor of the With-No-Lysine (K) (WNK) kinase family reduces blood pressure and increases electrolyte excretion in hypertensive rats. ...
