91 Result(s)
within
**g-wei Ma
Life Sciences
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Article
MicrobioRaman: an open-access web repository for microbiological Raman spectroscopy data
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Article
Open AccessLactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model
Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate ...
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Open AccessIdentification and characterization of endogenous biomarkers for hepatic vectorial transport (OATP1B3-P-gp) function using metabolomics with serum pharmacology
The organic anion-transporting polypeptide 1B3 and P-glycoprotein (P-gp) provide efficient directional transport (OATP1B3-P-gp) from the blood to the bile that serves as a key determinant of hepatic dispositio...
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Open AccessPost-crotonylation oxidation by a monooxygenase promotes acetyl-CoA synthetase degradation in Streptomyces roseosporus
Protein post-translational modifications (PTMs) with various acyl groups play central roles in Streptomyces. But whether these acyl groups can be further modified, and the influences of these potential modificati...
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Open AccessThe energy metabolism of Balantidium polyvacuolum inhabiting the hindgut of Xenocypris davidi
Anaerobic parasitic ciliates are a specialized group of ciliates that are adapted to anoxic and oxygen-depleted habitats. Among them, Balantidium polyvacuolum, which inhabits the hindgut of Xenocyprinae fishes, h...
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Open AccessLncRNA miR663AHG represses the development of colon cancer in a miR663a-dependent manner
The MIR663AHG gene encodes both miR663AHG and miR663a. While miR663a contributes to the defense of host cells against inflammation and inhibits colon cancer development, the biological function of lncRNA miR663AH...
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Open AccessExtracellular vesicles derived from CD4+ T cells carry DGKK to promote sepsis-induced lung injury by regulating oxidative stress and inflammation
Sepsis is an abnormal immune response after infection, wherein the lung is the most susceptible organ to fail, leading to acute lung injury. To overcome the limitations of current therapeutic strategies and de...
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In silico analysis of NAC gene family in the mangrove plant Avicennia marina provides clues for adaptation to intertidal habitats
NAC (NAM, ATAF1/2, CUC2) transcription factors (TFs) constitute a plant-specific gene family. It is reported that NAC TFs play important roles in plant growth and developmental processes and in response to bio...
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PIN5 is involved in regulating NH4+ efflux and primary root growth under high-ammonium stress via mediating intracellular auxin transport
Ammonium (NH4+) is an important nitrogen (N) source in many ecosystems and agricultural systems but excessive NH4+ is toxic to root growth and development, especially when NH4+ is the sole N source. Previous stud...
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Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1
G protein-coupled receptors (GPCRs) are regulated by various downstream proteins, of which the melanocortin receptor accessory protein 1 (MRAP1) is closely involved in the regulation of melanocortin receptor 2...
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Open AccessRUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis
Runt-related transcription factor 2 (RUNX2) is an osteogenesis-related transcription factor that has emerged as a prominent transcription repressing factor in carcinogenesis. However, the role of RUNX2 in brea...
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BMSCs overexpressed ISL1 reduces the apoptosis of islet cells through ANLN carrying exosome, INHBA, and caffeine
Early apoptosis of grafted islets is one of the main factors affecting the efficacy of islet transplantation. The combined transplantation of islet cells and bone marrow mesenchymal stem cells (BMSCs) can sign...
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Open AccessProfiles of transcriptome and metabolic pathways after hypobaric hypoxia exposure
Hypoxia is a risk factor for non-alcoholic fatty liver diseases, leading to permanent imbalance of liver lipid homeostasis and steatohepatitis. However, a detailed understanding of the metabolic genes and path...
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Open AccessStructural insights into ligand recognition and selectivity of somatostatin receptors
Somatostatin receptors (SSTRs) play versatile roles in inhibiting the secretion of multiple hormones such as growth hormone and thyroid-stimulating hormone, and thus are considered as targets for treating mult...
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MdMYB88/124 modulates apple tree microRNA biogenesis through post-transcription processing and/or transcription pathway
MicroRNAs are a class of endogenous small-RNA, which repress gene expression through post-transcriptional regulation. MdMYB88/124 (MYELOBLASTOSIS88/124), an R2R3-MYB transcription factor, regulates plants tole...
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Open AccessSandstorms cause shrinkage of Haloxylon ammodendron shrubs and limit their self-renewal
Haloxylon ammodendron is an excellent windproof and sand-fixing species whose shrubs are widely cultivated in arid desert areas of northwest China but are now at risk of degradation and shrinkage. Using the chlor...
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Open AccessInhibition of RIPK1 by ZJU-37 promotes oligodendrocyte progenitor proliferation and remyelination via NF-κB pathway
Receptor interacting serine/threonine protein kinase 1 (RIPK1) activation and necroptosis have been genetically and mechanistically linked with human multiple sclerosis and neurodegenerative diseases for which...
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Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function
The AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis. Although much has been learned on how low energy status and glucose starvation activate AMPK, how AMPK activity is properly...
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Open AccessRvD1 accelerates the resolution of inflammation by promoting apoptosis of the recruited macrophages via the ALX/FasL-FasR/caspase-3 signaling pathway
The uncontrolled inflammatory response caused by a disorder in inflammation resolution is one of the reasons for acute respiratory distress syndrome (ARDS). The macrophage pool markedly expands when inflammato...
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Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor
Melanocortins are peptide hormones critical for the regulation of stress response, energy homeostasis, inflammation, and skin pigmentation. Their functions are mediated by five G protein-coupled receptors (MC1...
