3,740 Result(s)
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**g-li Zhu
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Article
Subgroup analysis with concave pairwise fusion penalty for ordinal response
The growing popularity of data heterogeneity motivates people to identify homogeneous subgroups with identical parameters. Meanwhile, in many fields of recent data science for some applications, such as person...
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A mixed-valence polyoxometalate-based 3D inorganic framework cathode material for high-efficiency rechargeable AZIBs
The global trend towards new energy storage systems has stimulated the development of electrochemical energy storage technologies. Among these technologies, rechargeable aqueous zinc-ion batteries (AZIBs) have...
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Remote site-selective arene C–H functionalization enabled by N-heterocyclic carbene organocatalysis
Catalytic site-selective functionalization of distal C–H bonds represents a formidable challenge in organic synthesis. Particularly, the precise functionalization of distal aromatic C(sp2)–H bonds remains largely...
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Article
Surface diffraction beamline at the SSRF
BL02U2 of the Shanghai Synchrotron Radiation Facility is a surface diffraction beamline with a photon flux of 5.5 × 1012 photons/s at 10 keV and a beam size of 160 µm × 80 µm at the sample site. It is dedicated t...
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Open AccessHigh positive predictive value of CNVs detected by clinical exome sequencing in suspected genetic diseases
Genetic disorders often manifest as abnormal fetal or childhood development. Copy number variations (CNVs) represent a significant genetic mechanism underlying such disorders. Despite their importance, the eff...
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Open AccessHematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery
Leukemia is a kind of hematological malignancy originating from bone marrow, which provides essential signals for initiation, progression, and recurrence of leukemia. However, how to specifically deliver drugs...
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Overexpression of the MiAGL1 gene from mango promoted flowering in transgenic Arabidopsis
MADS-box genes play a vital role in the vegetative and reproductive growth of plants. In this study, a MiAGL1 gene was cloned and identified from mango (Mangifera indica L.). The DNA sequence of AGAMOUS-LIKE1 (Mi...
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Open AccessZero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering
Mutations in amino acid sequences can provoke changes in protein function. Accurate and unsupervised prediction of mutation effects is critical in biotechnology and biomedicine, but remains a fundamental chall...
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METTL3 promotes immature dental pulp stem cells-induced angiogenesis by regulating ETS1 mRNA stability in an m6A-HuR-dependent manner
Angiogenesis serves as the determinate element of pulp regeneration. Dental pulp stem cell (DPSC) implantation can promote the regeneration of dental pulp tissue. Herein, the role of m6A methyltransferase methylt...
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Article
PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels
PAQR4 is an orphan receptor in the PAQR family with an unknown function in metabolism. Here, we identify a critical role of PAQR4 in maintaining adipose tissue function and whole-body metabolic health. We demo...
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Open AccessNon-Abelian braiding of Fibonacci anyons with a superconducting processor
Quantum many-body systems with a non-Abelian topological order can host anyonic quasiparticles. It has been proposed that anyons could be used to encode and manipulate information in a topologically protected ...
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The effect of interfacial imperfection on the nonlinear dynamic behavior of composite laminates under low-velocity impact
Interfacial imperfection usually exists in composite laminates, which are widely used in the aerospace and shipbuilding industries. Such laminates are usually impacted by external loads in practical applicatio...
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Two sex pheromone receptors for sexual communication in the American cockroach
Volatile sex pheromones are vital for sexual communication between males and females. Females of the American cockroach, Periplaneta americana, produce and emit two sex pheromone components, periplanone-A (PA) an...
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Coherent phenomena and dynamics of lead halide perovskite nanocrystals for quantum information technologies
Solution-processed colloidal nanocrystals of lead halide perovskites have been intensively investigated in recent years in the context of optoelectronic devices, during which time their quantum properties have...
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DRAIC mediates hnRNPA2B1 stability and m6A-modified IGF1R instability to inhibit tumor progression
Type 1 insulin-like growth factor receptor (IGF1R) plays an important role in cancer, however, posttranscriptional regulation such as N6-methyladenosine (m6A) of IGF1R remains unclear. Here, we reveal a role for ...
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Open AccessThe effects of anastomoses between anterior and posterior circulation on postoperative prognosis of patients with moyamoya disease
Moyamoya disease (MMD) is a chronic ischemic cerebrovascular disease. Collateral circulation in MMD has emerged as a research focus. Our aims were to assess the impact of anastomoses between the anterior and p...
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Convolutional neural networks combined with classification algorithms for the diagnosis of periodontitis
We aim to develop a deep learning model based on a convolutional neural network (CNN) combined with a classification algorithm (CA) to assist dentists in quickly and accurately diagnosing the stage of periodon...
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Thermoelectric transport properties of p-type Bi2Se3–Sb2Se3–In2Se3 high entropy compounds
The introduction of entropy concept into thermoelectric materials recently has attracted broad interest. Herein, we showed the phase diagram of the ternary systems of Bi2Se3–Sb2Se3–In2Se3. Among the high entropy ...
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Open AccessTargeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-κB signaling pathway after myocardial ischemia-reperfusion injury
Reperfusion therapy is critical for saving heart muscle after myocardial infarction, but the process of restoring blood flow can itself exacerbate injury to the myocardium. This phenomenon is known as myocardi...
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Open AccessPost-sepsis psychiatric disorder: Pathophysiology, prevention, and treatment
Post-sepsis psychiatric disorder, encompassing anxiety, depression, post-traumatic stress disorder and delirium, is a highly prevalent complication secondary to sepsis, resulting in a marked increase in long-t...
