41 Result(s)
within
**g-Tian Ling
Life Sciences
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Article
Open AccessSPARC overexpression in allogeneic adipose-derived mesenchymal stem cells in dog dry eye model induced by benzalkonium chloride
Nowadays, companion and working dogs hold significant social and economic importance. Dry eye, also known as dry keratoconjunctivitis (KCS), a common disease in ophthalmology, can readily impact a dog’s workin...
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Open AccessPEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3
The peroxisome is a versatile organelle that performs diverse metabolic functions. PEX3, a critical regulator of the peroxisome, participates in various biological processes associated with the peroxisome. Whe...
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Mendelian randomization evidence for the causal effect of mental well-being on healthy aging
Mental well-being relates to multitudinous lifestyle behaviours and morbidities and underpins healthy aging. Thus far, causal evidence on whether and in what pattern mental well-being impacts healthy aging and...
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Open AccessGLUT1-mediated microglial proinflammatory activation contributes to the development of stress-induced spatial learning and memory dysfunction in mice
Stress is a recognized risk factor for cognitive decline, which triggers neuroinflammation involving microglial activation. However, the specific mechanism for microglial activation under stress and affects le...
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Open AccessFunctional analysis of differentially expressed circular RNAs in sheep subcutaneous fat
Circular RNAs (circRNAs), as important non-coding RNAs (ncRNAs), are involved in many biological activities. However, the exact chemical mechanism behind fat accumulation is unknown. In this paper, we obtained...
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Open AccessOsteocalcin ameliorates cognitive dysfunctions in a mouse model of Alzheimer’s Disease by reducing amyloid β burden and upregulating glycolysis in neuroglia
Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by the accumulation of amyloid β peptides (Aβ) and impaired glucose metabolism in the brain. Osteocalcin (OCN), an osteoblast...
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A deleterious Sar1c variant in rice inhibits export of seed storage proteins from the endoplasmic reticulum
We identified a dosage-dependent dominant negative form of Sar1c, which confirms the essential role of COPII system in mediating ER export of storage proteins in rice endosperm.
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Detection and Quantification of Candidatus Methanoperedens-Like Archaea in Freshwater Wetland Soils
Candidatus Methanoperedens-like archaea, which can use multiple electron acceptors (nitrate, iron, manganese, and sulfate) for anaerobic methane oxidation, could play an important role in reducing methane emissio...
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Open AccessHif-2α regulates lipid metabolism in alcoholic fatty liver disease through mitophagy
Disordered lipid metabolism plays an essential role in both the initiation and progression of alcoholic fatty liver disease (AFLD), and fatty acid β-oxidation is increasingly considered as a crucial factor for...
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Article
Physiological and FtCHS Gene Expression Responses to PEG-Simulated Drought and Cadmium Stresses in Tartary Buckwheat Seedlings
Drought and heavy metal contaminated soil has become one of the main factors affecting the sustainable development of agricultural production and the ecological environment. Tartary buckwheat is rich in flavon...
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Open AccessChromosome-scale genome assembly of Rhododendron molle provides insights into its evolution and terpenoid biosynthesis
Rhododendron molle (Ericaceae) is a traditional Chinese medicine, which has been used to treat rheumatism and relieve pain since ancient times. The characteristic grayanoids of this plant have been demonstrated ...
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Identification and expression profiling of HSP20 genes in Neoporphyra haitanensis
Small heat-shock proteins (sHSPs/HSP20s) are closely related to algae and plant thermotolerance, but studies on HSP20 family in Neoporphyra haitanensis are scarce. In this study, a total of eight HSP20 members we...
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Open AccessLAP2α preserves genome integrity through assisting RPA deposition on damaged chromatin
Single-stranded DNA (ssDNA) coated with replication protein A (RPA) acts as a key platform for the recruitment and exchange of genome maintenance factors in DNA damage response. Yet, how the formation of the s...
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Biocompatible Sensors Are Revolutionizing Healthcare Technologies
Sensors bridge the gap between disease diagnosis and the attainability of physiological indicators. The Internet of Things (IoT) and artificial intelligence algorithms have become the core of new-generation he...
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Sensor-Assisted Next-Generation Diagnostics: Emerging Concepts, Biomarkers, Technologies, and Challenges
The evolution of medical diagnosis has continued to broaden our understanding of diseases. The development of various omics technologies and the continuous advancement of medical sensor technology are pushing ...
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A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid–liquid phase separation to promote oncogenic YAP signaling
Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development. Liquid–liquid phase separation (LLPS) occurs in a wide ran...
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Open AccessA novel antiviral lncRNA, EDAL, shields a T309 O-GlcNAcylation site to promote EZH2 lysosomal degradation
The central nervous system (CNS) is vulnerable to viral infection, yet few host factors in the CNS are known to defend against invasion by neurotropic viruses. Long noncoding RNAs (lncRNAs) have been revealed ...
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Open AccessThe cell surface marker CD36 selectively identifies matured, mitochondria-rich hPSC-cardiomyocytes
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Open AccessRecovery of brain DHA-containing phosphatidylserine and ethanolamine plasmalogen after dietary DHA-enriched phosphatidylcholine and phosphatidylserine in SAMP8 mice fed with high-fat diet
Glycerophospholipids were the main components of cerebral cortex lipids, and there was a close association between lipid homeostasis and human health. It has been reported that dietary DHA-enriched phosphatidy...
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Open AccessRetinoid acid induced 16 deficiency aggravates colitis and colitis-associated tumorigenesis in mice
Inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC) is a serious health issue, but etiopathological factors remain unclear. Although some studies reported the roles of Retinoid acid...
