768 Result(s)
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**g-Tian **e
Life Sciences
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Article
Open AccessTranscriptome and metabolome analyses reveal regulatory networks associated with nutrition synthesis in sorghum seeds
Cereal seeds are vital for food, feed, and agricultural sustainability because they store and provide essential nutrients to human and animal food and feed systems. Unraveling molecular processes in seed devel...
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Open AccessKnockdown of AMIGO2 suppresses proliferation and migration through regulating PPAR-γ in bladder cancer
This study aims to reveal the relationship between AMIGO2 and proliferation, migration and tumorigenicity of bladder cancer, and explore the potential molecular mechanisms.
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Open AccessYTHDC1 aggravates high glucose-induced retinal vascular endothelial cell injury via m6A modification of CDK6
Retinal vascular endothelial cell (RVECs) injury is a major cause of morbidity and mortality among the patients with diabetes. RVECs dysfunction is the predominant pathological manifestation of vascular compli...
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Integrated Analysis of Transcriptome and Metabolome Reveal the Enhancement of Methyl Dihydrojasmonate on Physiological Indicators and Polyphyllins Biosynthesis in Paris polyphylla var. yunnanensis
Jasmonic acids, their effects on plant resistance and metabolites, have been extensively researched. However, methyl dihydrojasmonate (MDJ), a cost-effective and safe substitute for jasmonic acids, lacks suffi...
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Open AccessSPARC overexpression in allogeneic adipose-derived mesenchymal stem cells in dog dry eye model induced by benzalkonium chloride
Nowadays, companion and working dogs hold significant social and economic importance. Dry eye, also known as dry keratoconjunctivitis (KCS), a common disease in ophthalmology, can readily impact a dog’s workin...
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Open AccessInfluenza virus uses mGluR2 as an endocytic receptor to enter cells
Influenza virus infection is initiated by the attachment of the viral haemagglutinin (HA) protein to sialic acid receptors on the host cell surface. Most virus particles enter cells through clathrin-mediated e...
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Open AccessPEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3
The peroxisome is a versatile organelle that performs diverse metabolic functions. PEX3, a critical regulator of the peroxisome, participates in various biological processes associated with the peroxisome. Whe...
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Mendelian randomization evidence for the causal effect of mental well-being on healthy aging
Mental well-being relates to multitudinous lifestyle behaviours and morbidities and underpins healthy aging. Thus far, causal evidence on whether and in what pattern mental well-being impacts healthy aging and...
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Synergistic effect of chimeric antigen receptor modified with Bcl-2 on enhanced solid tumour targeting
Engineered T cells expressing chimeric antigen receptors (CARs) have shown remarkable therapeutic effects on haematological malignancies. However, CART cells are less effective on solid tumours mainly due to t...
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Characterization of the quality and physiological status of Penaeus vannamei in salt pans at various salinities
Shrimp farming in salt pans is an emerging aquaculture practice for producing high-quality shrimp. However, how high salinity in salt pans improves shrimp quality and the mechanisms underlying the physiologica...
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Open AccessMAL2 reprograms lipid metabolism in intrahepatic cholangiocarcinoma via EGFR/SREBP-1 pathway based on single-cell RNA sequencing
Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive cancer characterized by a poor prognosis and resistance to chemotherapy. In this study, utilizing scRNA-seq, we discovered that the tetra-transmembr...
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Open AccessEvolutionary radiation strategy revealed in the Scarabaeidae with evidence of continuous spatiotemporal morphology and phylogenesis
Evolutionary biology faces the important challenge of determining how to interpret the relationship between selection pressures and evolutionary radiation. The lack of morphological evidence on cross-species r...
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Open AccessLeptin receptor neurons in the ventral premammillary nucleus modulate emotion-induced insomnia
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Open AccessShared plasma metabolomic profiles of cognitive and mobility decline predict future dementia
Experiencing decline in both cognition and mobility is associated with a substantially higher dementia risk than cognitive decline only. Metabolites associated with both cognitive and mobility declines may be ...
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Circadian-independent light regulation of mammalian metabolism
The daily light–dark cycle is a key zeitgeber (time cue) for entraining an organism’s biological clock, whereby light sensing by retinal photoreceptors, particularly intrinsically photosensitive retinal gangli...
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Open AccessOTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation
Myddosome is an oligomeric complex required for the transmission of inflammatory signals from TLR/IL1Rs and consists of MyD88 and IRAK family kinases. However, the molecular basis for the self-assemble of Mydd...
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High-throughput fabrication of antimicrobial phage microgels and example applications in food decontamination
Engineered by nature, biological entities are exceptional building blocks for biomaterials. These entities can impart enhanced functionalities on the final material that are otherwise unattainable. However, pr...
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Dissolved oxygen and ammonia affect ammonia production via GDH/AMPK signaling pathway and alter flesh quality in Chinese perch (Siniperca chuatsi)
The dissolved oxygen (DO) and ammonia are crucial to the growth of Chinese perch (Siniperca chuatsi). Information on the effects of DO and total ammonia nitrogen (TAN) in regulating ammonia nitrogen excretion and...
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Open AccessFNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control
Mitochondrial dysfunction and oxidative stress are important mechanisms for secondary injury after traumatic brain injury (TBI), which result in progressive pathophysiological exacerbation. Although the Fibron...
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The chloroplast genome of Camellia sinensis var. assamica cv. Duntsa (Theaceae) and comparative genome analysis: mutational hotspots and phylogenetic relationships
Camellia sinensis (L.) O. Kuntze var. assamica cv. Duntsa (herein C. duntsa) has been used since ancient times in Hunan, China. To understand the genetic background information of C. duntsa and clarify the relati...
