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English
Biomedicine, general
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Article
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and pathogenicity. Given the emergence of increasingly drug-resistant str...
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Correction to: Efficacy and Safety of Neoadjuvant Subcutaneous Envafolimab in dMMR/MSI-H Locally Advanced Colon Cancer
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Article
Epitaxial quasi-2D/3D hybrid perovskite heterojunctions for photodetector with enhanced detectivity and stability
Although numerous metal halide perovskite materials have been investigated in the field of optoelectronic, the development of perovskite heterojunctions with exotic structures is still rare. Herein, we report ...
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In-situ study of the hydrogen peroxide photoproduction in seawater on carbon dot-based metal-free catalyst under operation condition
Hydrogen peroxide (H2O2) photoproduction in seawater with metal-free photocatalysts derived from biomass materials is a green, sustainable, and ultra environmentally friendly way. However, most photocatalysts are...
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Repeated-dose toxicity and toxicokinetic study of isobutylparaben in rats subcutaneously treated for 13 weeks
Parabens have historically served as antimicrobial preservatives in a range of consumables such as food, beverages, medications, and personal care products due to their broad-spectrum antibacterial and antifun...
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Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α7nAchR-dependent inactivation of microglial NLRP3 inflammasome
Ischemic stroke is a major cause of disability and death worldwide, and its management requires urgent attention. Previous studies have shown that vagus nerve stimulation (VNS) exerts neuroprotection in ischem...
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Controlling electrodeposited Ni layers by different-sized graphene oxides enables conductive e-textiles for the highly sensitive electrochemical detection of glucose
With the increasing popularity of wearable electronic devices, there is an urgent demand to develop electronic textiles (e-textiles) for device fabrication. Nevertheless, the difficulty in reconciliation betwe...
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Highly adaptive triboelectric tactile sensor on the foot of autonomous wall-climbing robots for detecting the adhesion state and avoiding the hazard
Due to the excellent maneuverability and obstacle crossing of legged robots, it is possible for an autonomous legged wall-climbing robots to replace manual inspection of ship exterior panels. However, when the...
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Article
Efficacy and Safety of Neoadjuvant Subcutaneous Envafolimab in dMMR/MSI-H Locally Advanced Colon Cancer
Neoadjuvant immunotherapy with programmed death-ligand 1 blockade for colon cancer, especially for mismatch repair-deficient (dMMR)/high microsatellite instability (MSI-H) colon cancer, has gained considerable...
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Article
Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury
Acute kidney injury (AKI) is often accompanied by uremic encephalopathy resulting from accumulation of uremic toxins in brain possibly due to impaired blood-brain barrier (BBB) function. Anionic uremic toxins ...
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Superatom-assembled boranes, carboranes, and low-dimensional boron nanomaterials based on aromatic icosahedral B12 and C2B10
Using the experimentally known aromatic icosahedral superatoms Ih B12H122− and D5d 1,12-C2B10H12 as building blocks and based on extensive density functional theory calculations, we predict herein a series of cor...
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Article
Open AccessPrognostic significance of platelet‑to‑albumin ratio in patients with nasopharyngeal carcinoma receiving concurrent chemoradiotherapy: a retrospective study of 858 cases
Despite evidence supporting the high correlation of the novel platelet-to-albumin ratio (PAR) with survival in diverse malignancies, its prognostic relevance in nasopharyngeal carcinoma (NPC) remains underexpl...
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Open AccessIFIT1 + neutrophil is a causative factor of immunosuppressive features of poorly cohesive carcinoma (PCC)
The importance of the immune microenvironment in poorly cohesive carcinoma (PCC) has been highlighted due to its limited response rate to conventional therapy and emerging treatment resistance. A combination o...
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Article
In situ reprogramming of cardiac fibroblasts into cardiomyocytes in mouse heart with chemicals
Cardiomyocytes are terminal differentiated cells and have limited ability to proliferate or regenerate. Condition like myocardial infarction causes massive death of cardiomyocytes and is the leading cause of d...
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Disruption of DNA-PKcs-mediated cGAS retention on damaged chromatin potentiates DNA damage-inducing agent-induced anti-multiple myeloma activity
Targeting DNA damage repair factors, such as DNA-dependent protein kinase catalytic subunit (DNA-PKcs), may offer an opportunity for effective treatment of multiple myeloma (MM). In combination with DNA damage...
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Open AccessMacrophage and fibroblast trajectory inference and crosstalk analysis during myocardial infarction using integrated single-cell transcriptomic datasets
Cardiac fibrosis after myocardial infarction (MI) has been considered an important part of cardiac pathological remodeling. Immune cells, especially macrophages, are thought to be involved in the process of fi...
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Article
Open AccessAssociation between estimated glucose disposal rate and atrial fibrillation recurrence in patients undergoing radiofrequency catheter ablation: a retrospective study
Previous studies have shown a clear link between insulin resistance (IR) and an elevated risk of atrial fibrillation (AF). However, the relationship between the estimated glucose disposal rate (eGDR), which se...
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Article
Effects of Kv1.3 knockout on pyramidal neuron excitability and synaptic plasticity in piriform cortex of mice
Kv1.3 belongs to the voltage-gated potassium (Kv) channel family, which is widely expressed in the central nervous system and associated with a variety of neuropsychiatric disorders. Kv1.3 is highly expressed ...
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Article
ABBV-744 alleviates LPS-induced neuroinflammation via regulation of BATF2-IRF4-STAT1/3/5 axis
Suppression of neuroinflammation using small molecule compounds targeting the key pathways in microglial inflammation has attracted great interest. Recently, increasing attention has been gained to the role of...
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Hydrogen-rich surface of MoC catalysts for efficient CO2 hydrogenation induced by a coupled hydrogen donator
Direct CO2 hydrogenation offers an important strategy for promoting the global carbon balance, but high thermodynamic and kinetic stability of CO2 has restricted its applicability to only a handful of industrial ...
