722 Result(s)
within
**fu Fu
Biomedicine
Oncology
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Article
Open AccessSurvival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study
Most gastrointestinal stromal tumors (GISTs) harbor c-KIT or PDGFRA mutations. Administration of tyrosine kinase inhibitors (TKIs) has significantly improved the survival of patients with GISTs. We aimed to evalu...
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Open AccessN6-methyladenosine modification of circMARK2 enhances cytoplasmic export and stabilizes LIN28B, contributing to the progression of Wilms tumor
The potential involvement of circular RNAs (circRNAs) and N6-methyladenosine (m6A) modification in the progression of Wilms tumor (WT) has not been fully elucidated. This study investigates the regulatory mechani...
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Open AccessUnbiasedly decoding the tumor microenvironment with single-cell multiomics analysis in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor prognosis and limited therapeutic options. Research on the tumor microenvironment (TME) of PDAC has propelled the developme...
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Open AccessLMO family gene polymorphisms and Wilms tumor susceptibility in Chinese children: a five-center case-control study
Wilms tumor is the most prevalent embryonal kidney malignancy in children worldwide. Previous genome-wide association study (GWAS) identified that LIM domain only 1 (LMO1) gene polymorphisms affected the suscepti...
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Open AccessClinical evaluation of an artificial intelligence-assisted cytological system among screening strategies for a cervical cancer high-risk population
Primary cervical cancer screening and treating precancerous lesions are effective ways to prevent cervical cancer. However, the coverage rates of human papillomavirus (HPV) vaccines and routine screening are l...
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Open AccessDevelopment of a risk prediction model for radiation dermatitis following proton radiotherapy in head and neck cancer using ensemble machine learning
This study aims to develop an ensemble machine learning-based (EML-based) risk prediction model for radiation dermatitis (RD) in patients with head and neck cancer undergoing proton radiotherapy, with the goal...
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Open AccessCorrelation between hemoglobin and the risk of common malignant tumors: a 1999–2020 retrospective analysis and causal association analysis
The role of hemoglobin (HGB) in common malignant tumors remains unclear.
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Open AccessAdvances in spatial transcriptomics and its applications in cancer research
Malignant tumors have increasing morbidity and high mortality, and their occurrence and development is a complicate process. The development of sequencing technologies enabled us to gain a better understanding...
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Open AccessPrognostic value of the Naples prognostic score in patients with intrahepatic cholangiocarcinoma after hepatectomy
The Naples Prognostic Score (NPS), integrating inflammatory and nutritional biomarkers, has been reported to be associated with the prognosis of various malignancies, but there is no report on intrahepatic cho...
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Open AccessDiagnostic performance of Node Reporting and Data System (Node-RADS) for assessing mesorectal lymph node in rectal cancer by CT
To compare the diagnostic performance of the Node-RADS scoring system and lymph node (LN) size in preoperative LN assessment for rectal cancer (RC), and to investigate whether the selection of size as the prim...
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Open AccessLIPUS regulates the progression of knee osteoarthritis in mice through primary cilia-mediated TRPV4 channels
Osteoarthritis (OA) is a common disease in middle-aged and elderly people. An imbalance in calcium ion homeostasis will contribute to chondrocyte apoptosis and ultimately lead to the progression of OA. Transie...
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Open AccessCausal relationship between lipid-lowering drugs and ovarian cancer, cervical cancer: a drug target mendelian randomization study
The causal impact of lipid-lowering drugs on ovarian cancer (OC) and cervical cancer (CC) has received considerable attention, but its causal relationship is still a subject of debate. Hence, the objective of ...
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Article
Open AccessClinical application of serum tumor abnormal protein in prostate cancer patients
To explore the clinical value of tumor abnormal protein (TAP) in the diagnosis and prognosis evaluation of prostate cancer.
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Open AccessOverexpression of COL11A1 confers tamoxifen resistance in breast cancer
Breast cancer is the most commonly diagnosed malignancy and benefits from endocrine agents such as tamoxifen. However, the development of drug resistance in cancerous cells often leads to recurrence, thus limi...
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Open AccessThe impact of bolus on clinical outcomes for post-mastectomy breast cancer patients treated with IMRT: data from China
This study aims to investigate the effects of chest wall bolus in intensity-modulated radiotherapy (IMRT) technology on clinical outcomes for post-mastectomy breast cancer patients.
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Article
Open AccessImmune cell patterns before and after neoadjuvant immune checkpoint blockade combined with chemoradiotherapy in locally advanced esophageal squamous cell carcinoma
Neoadjuvant immune checkpoint blockade (ICB) combined with chemoradiotherapy offers high pathologic complete response (pCR) rate for patients with locally advanced esophageal squamous cell carcinomas (ESCC). B...
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Open AccessTargeting neddylation and sumoylation in chemoresistant triple negative breast cancer
Triple negative breast cancer (TNBC) accounts for 15–20% of breast cancer cases in the United States. Systemic neoadjuvant chemotherapy (NACT), with or without immunotherapy, is the current standard of care fo...
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Open AccessNeuroendocrine carcinoma of the endometrium: a retrospective analysis of data from a single center
Neuroendocrine carcinoma (NEC) originating from the endometrium is rare, and there is limited knowledge regarding its diagnosis and optimal management. In this study, we present our experience with 11 patients...
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Open AccessIcaritin-curcumol activates CD8+ T cells through regulation of gut microbiota and the DNMT1/IGFBP2 axis to suppress the development of prostate cancer
Prostate cancer (PCa) incidence and mortality rates are rising. Our previous research has shown that the combination of icariin (ICA) and curcumol (CUR) induced autophagy and ferroptosis in PCa cells, and alte...
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Open AccessLINC00606 promotes glioblastoma progression through sponge miR-486-3p and interaction with ATP11B
LncRNAs regulate tumorigenesis and development in a variety of cancers. We substantiate for the first time that LINC00606 is considerably expressed in glioblastoma (GBM) patient specimens and is linked with ad...
