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Molecular Medicine
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Open AccessMiR-425-5p suppression of Crebzf regulates oocyte aging via chromatin modification
Female infertility due to declining oocyte quality with age remains a significant challenge for patients and physicians, despite extensive research efforts. Recent studies suggest that microRNAs (miRNAs), whic...
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Effect of high-fat diet on cerebral pathological changes of cerebral small vessel disease in SHR/SP rats
Cerebral small vessel diseases (CSVD) are neurological disorders associated with microvessels, manifested pathologically as white matter (WM) changes and cortical microbleeds, with hypertension as a risk facto...
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Effect of millets and probiotics on cancer prevention:exploring its nutritional composition and health benefits
This article explores the potential of millets and probiotics for the prevention of cancer, highlighting their contributions to the prevention and treatment of cancer.
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Aging is associated with impaired triggering of TRPV3-mediated cutaneous vasodilation: a crucial process for local heat exposure
Sensing temperature is vitally important to adapt our body to environmental changes. Local warm detection is required to initiate regulation of cutaneous blood flow, which is part of the peripheral thermoregul...
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Open AccessExtreme-aged patients (≥ 85 years) experience similar outcomes as younger geriatric patients following chronic subdural hematoma evacuation: a matched cohort study
Subdural hematoma (SDH) evacuation represents one of the most frequently performed neurosurgical procedures. Several reports cite a rise in both the age and number of patient’s requiring treatment, due in part...
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Association of birthweight and risk of incident dementia: a prospective cohort study
Given the epidemiological studies investigating the relationship between birthweight and dementia are limited. Our study aimed to explore the association between birthweight and the risk of dementia, cognitive...
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Open AccessAssociations of plasma proteomics and age-related outcomes with brain age in a diverse cohort
Machine learning models are increasingly being used to estimate “brain age” from neuroimaging data. The gap between chronological age and the estimated brain age gap (BAG) is potentially a measure of accelerat...
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Open AccessGreater myofibrillar protein synthesis following weight-bearing activity in obese old compared with non-obese old and young individuals
The mechanisms through which obesity impacts age-related muscle mass regulation are unclear. In the present study, rates of integrated myofibrillar protein synthesis (iMyoPS) were measured over 48-h prior-to a...
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Open AccessEndothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance
Obesity and exercise intolerance greatly reduce the life quality of older people. Prolyl hydroxylase domain-containing protein 2 (PHD2) is an important enzyme in modulating hypoxia-inducible factor-alpha (HIF)...
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Open AccessFunctional deterioration of vascular mitochondrial and glycolytic capacity in the aortic rings of aged mice
Vascular ageing is associated with increased arterial stiffness and cardiovascular mortality that might be linked to altered vascular energy metabolism. The aim of this study was to establish a Seahorse XFe96 ...
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Learning ratio performance on a brief visual learning and memory test moderates cognitive training gains in Double Decision task in healthy older adults
Cognitive training using a visual speed-of-processing task, called the Useful Field of View (UFOV) task, reduced dementia risk and reduced decline in activities of daily living at a 10-year follow-up in older ...
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Exploring the potential of combining transcranial magnetic stimulation and electroencephalography to investigate mild cognitive impairment and Alzheimer’s disease: a systematic review
Transcranial magnetic stimulation (TMS) and electroencephalography (EEG) are non-invasive techniques used for neuromodulation and recording brain electrical activity, respectively. The integration of TMS-EEG h...
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Open AccessResistance exercise effects on hippocampus subfield volumes and biomarkers of neuroplasticity and neuroinflammation in older adults with low and high risk of mild cognitive impairment: a randomized controlled trial
Physical exercise is suggested to promote hippocampal neuroplasticity by increasing circulating neurotrophic and anti-inflammatory factors. Our aim was to explore the interplay between the effect of progressiv...
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Systematic Review on Flow Cytometry as a Versatile Tool for Disease Diagnosis
Quantification and identification of cell fate remain to be the most important step within research and diagnostic laboratories.With advances in diagnostics and precision-medicine, there is a huge demand for c...
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Open AccessCell-free ascites from ovarian cancer patients induces Warburg metabolism and cell proliferation through TGFβ-ERK signaling
Ascites plays a key role in supporting the metastatic potential of ovarian cancer cells. Shear stress and carry-over of cancer cells by ascites flow support carcinogenesis and metastasis formation. In addition...
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Open AccessThe structural–functional-connectivity coupling of the aging brain
Aging primarily affects memory and executive functions, a relationship that may be underpinned by the fact that almost all adults over 60 years old develop small vessel disease (SVD). The fact that a wide rang...
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Open AccessShort-term fasting of a single amino acid extends lifespan
Diet and health are strongly linked, though the strict changes in diet required to improve health outcomes are usually difficult to sustain. We sought to understand whether short-term bouts of amino acid–speci...
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Physical activity intensity, frequency, duration, volume and the risk of possible sarcopenia in middle-aged and older adults
This study explored the association of physical activity (PA) from different dimensions including intensity, frequency, duration, and volume with possible sarcopenia (PSA), and established the PA cut-off value...
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Metabolic dysfunction and the development of physical frailty: an aging war of attrition
The World Health Organization recently declared 2021–2030 the decade of healthy aging. Such emphasis on healthy aging requires an understanding of the biologic challenges aging populations face. Physical frail...
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Mental Health and the Microbiome: A Review of Psychological Impacts of Gut Microflora
Starting from scratch to understand what a microbiome is and its significance in our daily lives has become a crucial subject of study. This review aims to delve into the impact of diet on the gut microbiota a...
