13,230 Result(s)
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New vaccine institute planned for UK
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Embryo research tests NIH's mettle
One of the most contentious issues facing the NIH this year will be deciding what types of human embryo research should receive federal funds. President Bill Clinton has already ruled out one whole area.
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The gene as the drug
Caplen et al. (pages 39–46) demonstrate that it is feasible to use liposomes to transfer a human gene in vivo. Can this vector mimic the ability of viruses to effectively transfer genetic information into target ...
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Making global blood safety a priority
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The Hot Zone: The Coming Plague
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Medical informatics in clinical medicine and the biosciences
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Lesion versus lumen
Skinner and colleagues (pages 69–73) show that MRI can be used to evaluate atherosclerotic lesions, non-invasively and in vivo
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Japan on verge of first gene therapy trial
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The form and the substance
By careful microscopic examination of in vitro fertilization (pages 47–52) Simerly et al. demonstrate the paternal origin of the human centrosome and reveal steps at which fertilization may fail.
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Human embryo research deserves public support
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Coxsackieviruses and diabetes
Two recent reports provide further evidence for a link between coxsackieviruses and the onset of IDDM, although a careful examination suggests it is still too early to conclude a definitive role.
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Angiogenesis in cancer, vascular, rheumatoid and other disease
Recent discoveries of endogenous negative regulators of angiogenesis, thrombospondin, angiostatin and glioma-derived angiogenesis inhibitory factor, all associated with neovascularized tumours, suggest a new p...
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The serum concentration of active transforming growth factor-β is severely depressed in advanced atherosclerosis
Recent evidence has led us to propose that transforming growth factor-β (TGF-β) is a key inhibitor of atherosclerosis. We show here that a population of patients with advanced atherosclerosis all have less act...
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Purification and expansion of human Schwann cells in vitro
The ability to culture cells from the human nervous system provides new insight into the pathophysiology of neurological diseases and could be crucial to the development of gene replacement therapies and neura...
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Imanishi–Kari finally gets appeal
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Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis
We report the results of a double-blind, placebo-controlled trial in nine cystic fibrosis (CF) subjects receiving cationic liposome complexed with a complementary DNA encoding the CF transmembrane conductance ...
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British medical schools fear funding changes
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Elimination of Ehrlich tumours by ATP-induced growth inhibition, glutathione depletion and X-rays
ATP-induced tumour growth inhibition is accompanied by a selective decrease in the content of the tripeptide glutathione (CSH) within the cancer cells in vivo. Depletion of cellular GSH sensitizes tumours to chem...
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Clinical trials in Japan
Although Japan's clinical trial system mimics that of the United States, there are certain flaws in the Japanese regulations that prevent it from working effectively.
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The paternal inheritance of the centrosome, the cell's microtubule-organizing center, in humans, and the implications for infertility
Successful fertilization in humans, achieved when parental chromosomes intermix at first mitosis, requires centrosome restoration and microtubule-mediated motility. Imaging of inseminated human oocytes reveals...