58 Result(s)

Article

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

Helicobacter pylori (H. pylori) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high prevalence and resistance make it difficult to tackle. A graph neur...

**xi Guo, **aosa Zhao, ** Lu, Li** Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

Mendelian randomization reveals association of gut microbiota with Henoch–Schönlein purpura and immune thrombocytopenia

Gut microbiota have been linked to immune thrombocytopenia (ITP) and Henoch–Schönlein purpura (HSP) in recent studies, but a cause-and-effect relationship is unclear. We used Mendelian randomization (MR) to as...

Chendong Jiang, Shu Deng, **aohan Ma, Juan Song… in International Journal of Hematology (2024)

Article

Diabetes and aortic dissection: unraveling the role of 3-hydroxybutyrate through mendelian randomization

In observational and experimental studies, diabetes has been reported as a protective factor for aortic dissection. 3-Hydroxybutyrate, a key constituent of ketone bodies, has been found to favor improvements i...

Shi Qiu, Zhen Liu, Wei-Dong Jiang, **-Hui Sun… in Cardiovascular Diabetology (2024)

Article

The association between the triglyceride-glucose index and in-stent restenosis in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis

Insulin resistance (IR) can lead to cellular metabolic disorders, activation of oxidative stress, and endothelial dysfunction, contributing to in-stent restenosis (ISR). The triglyceride-glucose index (TyG ind...

Haodong Jiang, Yuntong liu, Haoyu Guo, Zhihao Liu, Zhibo Li in BMC Cardiovascular Disorders (2024)

Article

Use of serum KL-6 and chest radiographic severity grade to predict 28-day mortality in COVID-19 patients with pneumonia: a retrospective cohort study

Coronavirus disease 2019 (COVID-19) has had a global social and economic impact. An easy assessment procedure to handily identify the mortality risk of inpatients is urgently needed in clinical practice. There...

**g Zou, Yi** Shi, Shan Xue, Handong Jiang in BMC Pulmonary Medicine (2024)

Article

Correction to: Efficacy of rTMS in treating functional impairment in post‑stroke patients: a systematic review and meta‑analysis

**aodong Duan, Delong Huang, Haoshu Zhong, Junhao Wu, Zhihan **ao… in Neurological Sciences (2024)

Article

The interaction of perfluoroalkyl acids and a family history of diabetes on arthritis: analyses of 2011–2018 NHANES

Whether a family history of diabetes (FHD) and exposure to perfluoroalkyl acids (PFAAs) are correlated with an increased risk of develo** arthritis remains unclear. This cross-sectional study was conducted t...

Shuting Yang, Xuqi Li, Zhengdong Jiang in BMC Public Health (2024)

Article

Circ_0000376 regulates miR-577/HK2/LDHA signaling pathway to promote the growth, invasion and glycolysis of osteosarcoma

Many studies have confirmed that circular RNAs (circRNAs) mediate the malignant progression of various tumors including osteosarcoma (OS). Our study is to uncover novel molecular mechanisms by which circ_00003...

Hongchun Dai, Guangming Yi, Dong Jiang… in Journal of Orthopaedic Surgery and Research (2024)

Article

Autosurv: interpretable deep learning framework for cancer survival analysis incorporating clinical and multi-omics data

Accurate prognosis for cancer patients can provide critical information for optimizing treatment plans and improving life quality. Combining omics data and demographic/clinical information can offer a more com...

Lindong Jiang, Chao Xu, Yuntong Bai, Anqi Liu, Yun Gong… in npj Precision Oncology (2024)

Article

Wrap** gastroduodenal artery stump with the teres hepatis ligament to prevent postpancreatectomy hemorrhage after pancreaticoduodenectomy

Gastroduodenal artery (GDA) stump erosion hemorrhage is a fatal complication after pancreaticoduodenectomy. This study aimed to determine whether GDA stump wrap** with the teres hepatis ligament during pancr...

**ang Zheng, Zedong Jiang, Zhenzhen Gao, Bo Zhou… in World Journal of Surgical Oncology (2023)

Article

Oncological prognosis and morbidity of hepatectomy in elderly patients with hepatocellular carcinoma: a propensity score matching and multicentre study

With increasing life expectancy, the number of elderly patients (≥ 65 years) with hepatocellular carcinoma (HCC) has steadily increased. Hepatectomy remains the first-line treatment for HCC patients. However, ...

Chuan-Ming Wang, Zi-**ang Chen, **-Chuan Ma, Jiang-Ming Chen, Dong Jiang… in BMC Surgery (2023)

Article

Correction: Discovery of novel non-peptidic and non-covalent small-molecule 3CL^pro inhibitors as potential candidate for COVID-19 treatment

Zhidong Jiang, Bo Feng, Yumin Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

The 100 most cited articles in malignant hyperthermia

Bibliometric analysis is a widely used method to identify and evaluate the trends and characteristics of the scientific publications in a specific research field. A large volume of literature has been publishe...

Yongzheng Han, Yinyin Qu, **aoxiao Wang… in Anesthesiology and Perioperative Science (2023)

Article

Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

Nuclear receptors NUR77 and NOR1 were identified as critical targets in acute myeloid leukemia (AML) therapy. Previously, we showed that Z-ligustilide (Z-LIG) selectively targeted AML by restoring NUR77 and NO...

Gen Liu, Zhi-gang Chen, Li-rong Yang, Yu-xia Rong, Qin Wang, Li Li… in Chinese Medicine (2023)

Article

Impact of non-regional lymph node metastases accurately revealed on ¹⁸F-PSMA-1007 PET/CT in the clinical management of metastatic hormone-sensitive prostate cancer

Non-regional lymph node (NRLN) metastases has shown increasing importance in the prognosis evaluation and clinical management of primary metastatic hormone-sensitive prostate cancer (mHSPC). Hence, this study ...

Zhangdong Jiang, Junjie Fan, Chaosheng Gan, **aoxin Dong, Guoqiang Gao… in EJNMMI Research (2023)

Article

Enhancing doctor-patient relationships in community health care institutions: the Patient Oriented Four Habits Model (POFHM) trial—a stepped wedge cluster randomized trial protocol

The poor relationship between doctors and patients is a long-standing, global problem. However, current interventions tend to focus on the training of physicians, while patient-targeted interventions still nee...

Yunying Zhu, Sisi Li, Ruotong Zhang, Lei Bao, ** Zhang, **aohua **ao… in BMC Psychiatry (2023)

Article

Emotional problems mediate the association between attention deficit/hyperactivity disorder and obesity in adolescents

Attention deficit/hyperactivity disorder (ADHD) has been identified as a risk factor for obesity in both children and adolescents. However, the mechanisms underlying the relationship between ADHD and obesity a...

Ke Li, Liangliang Chen, Kai Wang, **aodong Jiang, Yiting Ji… in BMC Psychiatry (2023)

Article

Discovery of novel non-peptidic and non-covalent small-molecule 3CL^pro inhibitors as potential candidate for COVID-19 treatment

Zhidong Jiang, Bo Feng, Yumin Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer

Genomic MET amplification and exon 14 skip** are currently clinically recognized biomarkers for stratifying subsets of non-small cell lung cancer (NSCLC) patients according to the predicted response to c-Met in...

Ji Zhou, Xu-Chao Zhang, Shan Xue, Mengdi Dai… in Signal Transduction and Targeted Therapy (2023)

Article

The phenotype and prediction of long-term physical, mental and cognitive COVID-19 sequelae 20 months after recovery, a community-based cohort study in China

Long-term sequelae clustering phenotypes are important for precise health care management in COVID-19 survivors. We reported findings for 1000 survivors 20 months after diagnosis of COVID-19 in a community-bas...

Yimiao Zhao, Le Shi, Zhendong Jiang, Na Zeng, Huan Mei, Yu Lu… in Molecular Psychiatry (2023)