94 Result(s)

Article

Identification of a sugarcane bacilliform virus promoter that is activated by drought stress in plants

Sugarcane (Saccharum spp.) is an important sugar and biofuel crop in the world. It is frequently subjected to drought stress, thus causing considerable economic losses. Transgenic technology is an effective breed...

Sheng-Ren Sun, **ao-Bin Wu, Jian-Sheng Chen, Mei-Ting Huang… in Communications Biology (2024)

Article

Author Correction: Stiff matrix induces exosome secretion to promote tumour growth

Bin Wu, Di-Ao Liu, Lei Guan, Phyoe Kyawe Myint, LiKang Chin… in Nature Cell Biology (2024)

Article

A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings

Obesity is a major public health crisis. Multi-specific peptides have emerged as promising therapeutic strategies for clinical weight loss. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic ...

Murielle M. Véniant, Shu-Chen Lu, Larissa Atangan, Renee Komorowski… in Nature Metabolism (2024)

Article

Activated hepatic stellate cell-derived Bmp-1 induces liver fibrosis via mediating hepatocyte epithelial-mesenchymal transition

Liver fibrosis is a reparative response to injury that arises from various etiologies, characterized by activation of hepatic stellate cells (HSCs). Periostin, a secreted matricellular protein, has been report...

Sizhe Wan, **anzhi Liu, Ruonan Sun, Huiling Liu, Jie Jiang, Bin Wu in Cell Death & Disease (2024)

Article

Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice

Glutathione synthetase (GSS) catalyzes the final step in the synthesis of glutathione (GSH), a well-established antioxidant. Research on the specific roles of the Gss gene during spermatogenesis remains limited d...

Haixia Zhu, Yin Cheng, **anmei Wang, **ng Yang, Min Liu, Jun Liu… in Cell Death & Disease (2023)

Article

Draft genome of Castanopsis chinensis, a dominant species safeguarding biodiversity in subtropical broadleaved evergreen forests

Castanopsis is the third largest genus in the Fagaceae family and is essentially tropical or subtropical in origin. The species in this genus are mainly canopy-dominant trees, and the key components of evergreen ...

Pan Chen, Ju-Yu Lian, Bin Wu, Hong-Lin Cao, Zhi-Hong Li… in BMC Genomic Data (2023)

Article

Correction: Tim-3 protects against cisplatin nephrotoxicity by inhibiting NF-κB-mediated inflammation

Peiyao Li, Xuemiao Li, Wenbin Wu, Mengjia Hou, Guanyi Yin… in Cell Death Discovery (2023)

Article

Tim-3 protects against cisplatin nephrotoxicity by inhibiting NF-κB-mediated inflammation

The impact of Tim-3 (T cell immunoglobulin and mucin domain-containing protein 3) on cisplatin-induced acute kidney injury was investigated in this study. Cisplatin-induced Tim-3 expression in mice kidney tiss...

Peiyao Li, Xuemiao Li, Wenbin Wu, Mengjia Hou, Guanyi Yin… in Cell Death Discovery (2023)

Article

TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis

Sarcopenia has become a leading cause of disability and mortality in the elderly. It has been reported that programmed cell death (PCD) is associated with the development of sarcopenia that is characterized by...

**gying Wu, Siming Lin, Weixiao Chen, Guili Lian, Weibin Wu… in Cell Death Discovery (2023)

Article

RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling

Spermatogenesis is an extremely complex process, and any obstruction can cause male infertility. RhoGDIα has been identified as a risk of male sterility. In this study, we generate RhoGDIα knockout mice, and find...

Haixia Zhu, Zongzhuang Wen, Aizhen Zhang, Dongyue Liu… in Communications Biology (2023)

Article

Comparative genome anatomy reveals evolutionary insights into a unique amphitriploid fish

Triploids are rare in nature because of difficulties in meiotic and gametogenic processes, especially in vertebrates. The Carassius complex of cyprinid teleosts contains sexual tetraploid crucian carp/goldfish (C...

Yang Wang, **-Yin Li, Wen-Jie Xu, Kun Wang, Bin Wu, Meng Xu… in Nature Ecology & Evolution (2022)

Article

TAS-Seq is a robust and sensitive amplification method for bead-based scRNA-seq

Single-cell RNA-sequencing (scRNA-seq) is valuable for analyzing cellular heterogeneity. Cell composition accuracy is critical for analyzing cell–cell interaction networks from scRNA-seq data. However, droplet...

Shigeyuki Shichino, Satoshi Ueha, Shinichi Hashimoto… in Communications Biology (2022)

Article

Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH

Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions wi...

Alena Stsiapanava, Chenrui Xu, Shunsuke Nishio… in Nature Structural & Molecular Biology (2022)

Article

Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis

Berberine (BBR) has been explored as a potential anti-liver fibrosis agent, but the underlying mechanisms are unknown. In the current study, we aimed to investigate the molecular mechanisms underlying the effe...

Jiazhi Yi, Shuyun Wu, Siwei Tan, Yunfei Qin, **ng Wang, Jie Jiang… in Cell Death Discovery (2021)

Article

Urinary peptidomics reveals proteases involved in idiopathic membranous nephropathy

Idiopathic membranous nephropathy (IMN) is a cause of nephrotic syndrome that is increasing in incidence but has unclear pathogenesis. Urinary peptidomics is a promising technology for elucidating molecular me...

Baoxu Lin, Jianhua Liu, Yue Zhang, Yabin Wu, Shixiao Chen, Yibo Bai… in BMC Genomics (2021)