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Article
Open AccessOuabain prevents pathological cardiac hypertrophy and heart failure through activation of phosphoinositide 3-kinase α in mouse
Use of low doses of digitalis to prevent the development of heart failure was advocated decades ago, but conflicting results of early animal studies dissuaded further research on this issue. Recent discoverie...
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Article
Physiological and cellular responses to fluoride stress in tea (Camellia sinensis) leaves
Tea (Camellia sinensis (L.) O. Kuntze) hyper-accumulates fluoride (F), mainly in the leaves. To understand how tea copes with the stress caused by F, we tracked photosynthesis, antioxidant defense, and cell ultra...
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Article
Species-specific and general allometric equations for estimating tree biomass components of subtropical forests in southern China
Chinese subtropical forests contain a diversity of tree species and exhibit a high carbon (C) sequestration capacity, but biomass and C stock assessments in subtropical secondary forests remain uncertain becau...
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Article
Nitrogen and phosphorus concentrations and allocation strategies among shrub organs: the effects of plant growth forms and nitrogen-fixation types
We aimed to explore the influences of plant functional groups on nutrient concentrations and allocation strategies among shrub organs, as well as to examine the effects of climate, soil and species on nutrient...
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Article
Structural basis of tubulin detyrosination by vasohibins
Microtubules are regulated by post-translational modifications of tubulin. The ligation and cleavage of the carboxy-terminal tyrosine of α-tubulin impact microtubule functions during mitosis, cardiomyocyte con...
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Article
Enhanced human lysozyme production by Pichia pastoris via periodic glycerol and dissolved oxygen concentrations control
In human lysozyme (hLYZ) production by Pichia pastoris, the glycerol fed-batch phase was generally implemented under the environment of “oxygen sufficient-glycerol limited” to achieve high cell-density cultivatio...
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Article
The key players of parthanatos: opportunities for targeting multiple levels in the therapy of parthanatos-based pathogenesis
Parthanatos is a form of regulated cell death involved in the pathogenesis of many diseases, particularly neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, Huntington’s disease, an...
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Article
Open AccessCryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state
The conserved ATPase p97 (Cdc48 in yeast) and adaptors mediate diverse cellular processes through unfolding polyubiquitinated proteins and extracting them from macromolecular assemblies and membranes for disag...
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Article
Depth-Dependent Controls Over Soil Organic Carbon Stock across Chinese Shrublands
Soil organic carbon (SOC) in shrublands is an important component of global carbon cycling. However, there is a dearth of large-scale systematic observations of SOC stocks at different soil depths, and it rema...