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Article
Open AccessClinical application of targeted next-generation sequencing in severe pneumonia: a retrospective review
The precise identification of the underlying causes of infectious diseases, such as severe pneumonia, is essential, and the development of next-generation sequencing (NGS) has enhanced the effectiveness of pat...
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Article
Open AccessLiposome-lentivirus for miRNA therapy with molecular mechanism study
Cancer stem cells (CSCs) play a vital role in the occurrence, maintenance, and recurrence of solid tumors. Although, miR-145-5p can inhibit CSCs survival, poor understanding of the underlying mechanisms hamper...
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Article
Open AccessRunx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice
After spinal cord injury, astrocytes undergo a reactive process and form an astroglial scar, which impedes the regeneration of axons. The role of Runx2 in promoting the transformation of astrocytes in the cent...
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Article
Open AccessAnalysis of Jet Blast Distance of a Refined Engine Nozzle Model for Departing Aircraft
To evaluate the influence distance and evolution law of the jet blast under the full thrust state of the aircraft engine, we constructed a refined single-engine nozzle model in this study. Using a specific B73...
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Article
Open AccessAssociation of glucose-lowering drug target and risk of gastrointestinal cancer: a mendelian randomization study
Glucose-lowering drug is associated with various cancers, but the causality with gastrointestinal cancer risk is rarely reported. We aimed to explore the causality between them in this Mendelian randomization ...
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Article
Open AccessA novel PDPN antagonist peptide CY12-RP2 inhibits melanoma growth via Wnt/β-catenin and modulates the immune cells
Podoplanin (PDPN) is a highly conserved, mucin-type protein specific to the lymphatic system. Overexpression of PDPN is associated with the progression of various solid tumors, and plays an important roles in ...
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Article
Advisory Editor profile: Daqing Chen
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Article
Open AccessHepatocyte-specific Sox9 knockout ameliorates acute liver injury by suppressing SHP signaling and improving mitochondrial function
Sex determining region Y related high-mobility group box protein 9 (Sox9) is expressed in a subset of hepatocytes, and it is important for chronic liver injury. However, the roles of Sox9+ hepatocytes in response...
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Article
Open AccessCntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte–microglia C3-C3aR pathway
Parkinson’s disease (PD) is the most common progressive neurodegenerative movement disorder, which is characterized by dopaminergic (DA) neuron death and the aggregation of neurotoxic α-synuclein. Cntnap4, a risk...
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Article
Open AccessLetter to the editor, “Effects of vitamin D deficiency on blood lipids and bone metabolism: a large cross-sectional study”
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Article
Open AccessNetwork evolution of regional brain volumes in young children reflects neurocognitive scores and mother’s education
The maturation of regional brain volumes from birth to preadolescence is a critical developmental process that underlies emerging brain structural connectivity and function. Regulated by genes and environment,...
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Article
Open AccessTranslation and validation of the Chinese ABCD risk questionnaire to evaluate adults’ awareness and knowledge of the risks of cardiovascular diseases
Assessment of health beliefs and risk perception is a critical means to prevent coronary heart disease, but there are few such studies on assessment in the Chinese population. Given the demonstrated value and ...
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Article
Open AccessPFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation
Cancer cells adopt metabolic reprogramming to promote cell survival under metabolic stress. A key regulator of cell metabolism is AMP-activated protein kinase (AMPK) which promotes catabolism while suppresses ...
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Article
Open AccessPegylated liposomal doxorubicin in patients with epithelial ovarian cancer
To evaluate the efficacy and safety of PLD in treating of in patients who experience epithelial ovarian, fallopian tubal, and peritoneal cancer progression within 12 months after the first-line platinum-based ...
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Article
Open AccessAcclimatization of photosynthetic apparatus and antioxidant metabolism to excess soil cadmium in Buddleja spp.
Heavy metal (HM) pollutants can cause serious phytotoxicity or oxidative stress in plants. Buddleja L., commonly known as “butterfly bushes”, are frequently found growing on HM-contaminated land. However, to date...
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Article
Open AccessTime dynamics of COVID-19
We apply tools from functional data analysis to model cumulative trajectories of COVID-19 cases across countries, establishing a framework for quantifying and comparing cases and deaths across countries longit...
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Article
Open AccessBroadband bifunctional Luneburg–Fisheye lens based on anisotropic metasurface
Luneburg lenses and Maxwell fisheye lenses possess distinct properties of focusing, well beyond conventional lenses made of uniform materials. In this paper, a planar broadband bifunctional Luneburg-fisheye le...
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Article
Open AccessThe physical significance of acoustic parameters and its clinical significance of dysarthria in Parkinson’s disease
Dysarthria is universal in Parkinson’s disease (PD) during disease progression; however, the quality of vocalization changes is often ignored. Furthermore, the role of changes in the acoustic parameters of pho...
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Article
Open AccessTranscriptomic analysis of the testicular fusion in Spodoptera litura
Lepidoptera is one group of the largest plant-feeding insects and Spodoptera litura (Lepidoptera: Noctuidae) is one of the most serious agricultural pests in Asia countries. An interesting and unique phenomenon f...
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Chapter and Conference Paper
Predicting Customer Profitability Dynamically over Time: An Experimental Comparative Study
In this paper a comparative study is presented on dynamic prediction of customer profitability over time. Customer profitability is measured by Recency, Frequency, and Monetary (RFM) model. A real transactiona...
