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  1. Article

    Open Access

    DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

    Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently eme...

    Martin Schröder, Martin Renatus, **aoyou Liang, Fabian Meili… in Nature Communications (2024)

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  2. Article

    Open Access

    Identification of the HECT E3 ligase UBR5 as a regulator of MYC degradation using a CRISPR/Cas9 screen

    MYC oncoprotein is a multifunctional transcription factor that regulates the expression of a large number of genes involved in cellular growth, proliferation and metabolism. Altered MYC protein level lead to c...

    Lina Schukur, Tamara Zimmermann, Ole Niewoehner, Grainne Kerr… in Scientific Reports (2020)

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    Article

    Manumycin polyketides act as molecular glues between UBR7 and P53

    Molecular glues are an intriguing therapeutic modality that harness small molecules to induce interactions between proteins that typically do not interact. However, such molecules are rare and have been discov...

    Yosuke Isobe, Mikiko Okumura, Lynn M. McGregor… in Nature Chemical Biology (2020)