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Article
Association of prostate cancer SLCO gene expression with Gleason grade and alterations following androgen deprivation therapy
SLCO-encoded transporters have been associated with progression to castration-resistant prostate cancer (CRPC) after initiation of androgen deprivation therapy (ADT). Although expressed at lower levels than in CR...
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Article
Cervical Lymph Node Fine-Needle Aspiration and Needle-Wash Thyroglobulin Reflex Test for Papillary Thyroid Carcinoma
Fine-needle aspiration (FNA) cytology coupled with needle-wash thyroglobulin (FNA-Tg) testing is recommended for cervical lymph node (LN) biopsies in patients with a history of papillary thyroid carcinoma (PTC...
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Article
Open AccessKi67 Proliferative Index in Carcinoid Tumors Involving Ovary
Primary ovarian carcinoid tumors are rare neoplasms that constitute less than 0.1% of all ovarian carcinomas. However, carcinoid tumors metastatic to ovaries are more common. Cell proliferative rate is an impo...
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Article
Open AccessQuantitative comparison and reproducibility of pathologist scoring and digital image analysis of estrogen receptor β2 immunohistochemistry in prostate cancer
Digital image analysis offers advantages over traditional pathologist visual scoring of immunohistochemistry, although few studies examining the correlation and reproducibility of these methods have been perfo...
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Article
Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer
Genomic analysis of a single metastasis informs about the oncogenic—and potentially druggable—genomic alterations present in other tumors within the same man with metastatic prostate cancer.
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Article
Epithelial mesenchymal-like transition occurs in a subset of cells in castration resistant prostate cancer bone metastases
TGFβ is a known driver of epithelial-mesenchymal transition (EMT) which is associated with tumor aggressiveness and metastasis. However, EMT has not been fully explored in clinical specimens of castration-resi...
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Article
Open AccessComplex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer
A hypermutated subtype of advanced prostate cancer was recently described, but prevalence and mechanisms have not been well-characterized. Here we find that 12% (7 of 60) of advanced prostate cancers are hyper...
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Article
Prostate cancer derived prostatic acid phosphatase promotes an osteoblastic response in the bone microenvironment
Approximately 90 % of patients who die of prostate cancer (PCa) have bone metastases, often promoting osteoblastic lesions. We observed that 88 % of castration-resistant PCa (CRPC) bone metastases express pros...
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Article
Integrin alpha2beta1 (α2β1) promotes prostate cancer skeletal metastasis
Men who die of prostate cancer (PCa) do so because of systemic metastases, the most frequent of which are within the skeleton. Recent data suggest that the colonization of the skeleton is mediated in part by c...
