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Article
Open AccessDetection for gene-gene co-association via kernel canonical correlation analysis
Currently, most methods for detecting gene-gene interaction (GGI) in genomewide association studies (GWASs) are limited in their use of single nucleotide polymorphism (SNP) as the unit of association. One way ...
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Article
Open AccessA powerful latent variable method for detecting and characterizing gene-based gene-gene interaction on multiple quantitative traits
On thinking quantitatively of complex diseases, there are at least three statistical strategies for analyzing the gene-gene interaction: SNP by SNP interaction on single trait, gene-gene (each can involve mult...
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Article
Open AccessLocal well-posedness and persistence properties for a model containing both Camassa-Holm and Novikov equation
This paper deals with the Cauchy problem for a generalized Camassa-Holm equation with high-order nonlinearities,
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Article
Open AccessIntegrative Bayesian variable selection with gene-based informative priors for genome-wide association studies
Genome-wide Association Studies (GWAS) are typically designed to identify phenotype-associated single nucleotide polymorphisms (SNPs) individually using univariate analysis methods. Though providing valuable insi...
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Article
Open AccessA powerful score-based test statistic for detecting gene-gene co-association
The genetic variants identified by Genome-wide association study (GWAS) can only account for a small proportion of the total heritability for complex disease. The existence of gene-gene joint effects which con...
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Article
Open AccessA powerful score-based statistical test for group difference in weighted biological networks
Complex disease is largely determined by a number of biomolecules interwoven into networks, rather than a single biomolecule. A key but inadequately addressed issue is how to test possible differences of the n...
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Article
Open AccessA novel Markov Blanket-based repeated-fishing strategy for capturing phenotype-related biomarkers in big omics data
We propose a novel Markov Blanket-based repeated-fishing strategy (MBRFS) in attempt to increase the power of existing Markov Blanket method (DASSO-MB) and maintain its advantages in omic data analysis.
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Article
Open AccessNetwork or regression-based methods for disease discrimination: a comparison study
In stark contrast to network-centric view for complex disease, regression-based methods are preferred in disease prediction, especially for epidemiologists and clinical professionals. It remains a controversy ...
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Article
Open AccessA powerful weighted statistic for detecting group differences of directed biological networks
Complex disease is largely determined by a number of biomolecules interwoven into networks, rather than a single biomolecule. Different physiological conditions such as cases and controls may manifest as diffe...
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Article
A new generalised two-component Camassa–Holm type system with waltzing peakons and wave breaking
This paper mainly investigate the Cauchy problem for the generalised two-component Camassa–Holm type system, which includes the celebrated Camassa–Holm equation, Degasperis equation, Novikov equation, and the ...
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Article
Effect of salinity on the decomposition of soil organic carbon in a tidal wetland
Climate warming and sea level rise have the potential to change the salt level of soil in tidal wetlands. And it is important to clarify the process and the mechanism of decomposition of soil organic carbon in...
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Article
Bioprocess development of a stable FUT8−/−-CHO cell line to produce defucosylated anti-HER2 antibody
In recent years, an increasing number of defucosylated therapeutic antibodies have been applied in clinical practices due to their better efficacy compared to fucosylated counterparts. The establishment of sta...
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Chapter and Conference Paper
Meshing Point Clouds with Predicted Intrinsic-Extrinsic Ratio Guidance
We are interested in reconstructing the mesh representation of object surfaces from point clouds. Surface reconstruction is a prerequisite for downstream applications such as rendering, collision avoidance for...
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Article
Studying the Role of a Single Mutation of a Family 11 Glycoside Hydrolase Using High-Resolution X-ray Crystallography
XynII is a family 11 glycoside hydrolase that uses the retaining mechanism for catalysis. In the active site, E177 works as the acid/base and E86 works as the nucleophile. Mutating an uncharged residue (N44) t...
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Article
The trans-ancestral genomic architecture of glycemic traits
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregate...
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Article
Screening and functional analysis of differentially expressed lncRNAs in rapid atrial pacing dog atrial tissue
Atrial fibrillation (AF) is one of the most commonly sustained arrhythmias in clinical practice. Long non-coding RNAs (lncRNAs) are gene regulatory elements involved in the development of several diseases. We ...
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Article
Adsorption Mechanism and Electrochemical Properties of Methyl Blue onto Magnetic CoxCu(1–x)Fe2O4 Nanoparticles Prepared via an Alcohol Solution of Nitrate Combustion and Calcination Process
Magnetic CoxCu(1–x)Fe2O4 nanoparticles were prepared via an alcohol solution of nitrate combustion and calcination process. Their magnetic properties, microstructure, and element composition were measured by XRD,...
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Article
Open AccessPeer-to-peer electricity trading system: smart contracts based proof-of-benefit consensus protocol
Nowadays, people trade electricity through centralized companies or organizations which is vulnerable to cyber attacks and incapable of co** with increasing demands from stakeholders. In this paper, we propo...
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Article
Strong and Weak Convergence Theorems for General Mixed Equilibrium, General Variational Inequality, and Fixed Point Problems for Two Nonexpansive Semigroups in Hilbert Spaces
In this paper, we introduce some iterative algorithms for finding a common element of the set of solutions of the general mixed equilibrium problem and a general variational inequality for two cocoercive mappi...
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Article
Open AccessFyn kinase regulates dopaminergic neuronal apoptosis in animal and cell models of high glucose (HG) treatment
High glucose (HG) is linked to dopaminergic neuron loss and related Parkinson’s disease (PD), but the mechanism is unclear.
