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Open AccessKK-LC-1, a biomarker for prognosis of immunotherapy for primary liver cancer
There is mounting evidence that patients with liver cancer can benefit from Immune checkpoint inhibitors. However, due to the high cost and low efficacy, we aimed to explore new biomarkers for predicting the e...
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Open AccessUnconventional posttranslational modification in innate immunity
Pattern recognition receptors (PRRs) play a crucial role in innate immunity, and a complex network tightly controls their signaling cascades to maintain immune homeostasis. Within the modification network, pos...
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Open AccessMitigating urban heat island through neighboring rural land cover
Globally, the deteriorating Urban Heat Island (UHI) effect poses a significant threat to human health and undermines ecosystem stability. UHI mitigation strategies have been investigated and utilized extensive...
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Exploring the interaction strategy and release timing for robot-to-human handovers with manually guided motion
Object handover is one of the fundamental tasks of service robots. This paper focuses on a robot-to-human object handover controller applied to a domestic service robot. People in need often have manual operat...
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Open AccessEfficacy of MAGE-A4 long peptide as a universal immunoprevention cancer vaccine
The clinical application of peptide vaccines in tumor immunotherapy holds significant promise. Peptide-based tumor vaccines are currently subject to certain limitations in clinical trials, including the challe...
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Roles and Mechanisms of miRNAs in Abdominal Aortic Aneurysm: Signaling Pathways and Clinical Insights
Abdominal aortic aneurysm refers to a serious medical condition that can cause the irreversible expansion of the abdominal aorta, which can lead to ruptures that are associated with up to 80% mortality. Curren...
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Genome-Wide Identification, Evolutionary and Expression Analysis of Cyclin-Dependent Kinase Gene Family Members in Moso Bamboo (Phyllostachys edulis)
Cyclin-dependent kinase (CDK), the pivotal controller of cell cycle progression, is involved in stress resistance and plant growth. Moso bamboo (Phyllostachys edulis) with surprisingly rapid growth depends on con...
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Influence of Excavation Inner Diameter on the Unloading Deformation and Failure Characteristics of Surrounding Rock
The develo** trend in tunnel engineering is toward the expansion of the tunnel’s inner diameter, which is bound to affect the deformation of the tunnel surrounding rock. To address this problem, transient an...
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Autophagy Regulation Attenuates Neuroinflammation and Cognitive Decline in an Alzheimer's Disease Mouse Model with Chronic Cerebral Hypoperfusion
This study investigates the role of autophagy regulation in modulating neuroinflammation and cognitive function in an Alzheimer's disease (AD) mouse model with chronic cerebral hypoperfusion (CCH). Using the A...
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Open AccessChronic endometritis multiplies the recurrence risk of endometrial polyps after transcervical resection of endometrial polyps: a prospective study
To investigate the impact of chronic endometritis (CE) on the recurrence of endometrial polyps (EPs) in premenopausal women after transcervical resection of endometrial polyps (TCRP).
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Open AccessBiomimetic lubricant-grafted surfaces on laser-textured microwell arrays with multifunctionality
Recently, various slippery liquid-infused porous surfaces (SLIPS) have been fabricated for the protection of various materials. However, these SLIPSs are limited by their underlying storage structure and super...
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Open AccessThe advanced lung cancer inflammation index is associated with mortality in peritoneal dialysis patients
There is still a very high morbidity and mortality rate for patients undergoing peritoneal dialysis (PD). The advanced lung cancer inflammation index (ALI) has been demonstrated to be associated with the progn...
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Preparation of Molecularly Imprinted Bacterial Cellulose Nanofiber Nonwovens for Selectively Removing Dye Molecule from Aqueous Solution
In this study, a novel surface dye molecularly imprinted bacterial cellulose nanofiber nonwoven (DMIBC) has been successfully prepared using two-step process by surface molecule-imprinting method combined with...
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Mechanical characteristics study of bimrocks with different cementation types from a microstructural perspective
In the evolving field of geotechnical engineering, the study of bimrocks (block-in-matrix rocks) presents unique challenges and opportunities. Based on laboratory uniaxial compression tests (UCTs) and their co...
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Open AccessInvestigating the three-dimensional myocardial micro-architecture in the laminar structure using X-ray phase-contrast microtomography
A comprehensive grasp of the myocardial micro-architecture is essential for understanding diverse heart functions. This study aimed to investigate three-dimensional (3D) cardiomyocyte arrangement in the lamina...
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Alcohol imagery in popular films in China, 2001–2020
This study aims to identify the level and trend of alcohol imagery in popular films in China from 2001 to 2020. We divided the running time of the annual 20 top-grossing films in China into 5-min intervals and...
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Open AccessComparison of functional outcomes following early and delayed arthroscopic repair for traumatic and non-traumatic rotator cuff injuries
The effects of the timing of surgical repair on the outcomes of traumatic and non-traumatic rotator cuff injuries (RCI) remain elusive. Thus, this study aimed to compare differences in outcomes following the r...
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Open AccessTumor microenvironment responsive nano-herb and CRISPR delivery system for synergistic chemotherapy and immunotherapy
Chemoresistance remains a significant challenge for effective breast cancer treatment which leads to cancer recurrence. CRISPR-directed gene editing becomes a powerful tool to reduce chemoresistance by reprogr...
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Advancing seismic landslide susceptibility modeling: a comparative evaluation of deep learning models through particle swarm optimization
Landslides triggered by earthquakes pose significant risks in mountainous regions, necessitating advanced modeling techniques for accurate susceptibility assessment. Despite progress, there remains a critical ...
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Kinetics and mechanism of Ce deposition in LiCl–KCl molten salt: a computational and experimental study
The present study developed a finite element model to study the electrodeposition process of Ce(III) from LiCl–KCl eutectic molten salt for pyroprocessing of spent nuclear fuel. The input parameters for the mo...
