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Article
Open AccessSilencing HE4 alleviates the renal fibrosis in lupus nephritis mice by regulating the C3/MMPs/prss axis
To explore the regulatory effect of human epididymis protein 4 (HE4) on renal fibrosis in mice with lupus nephritis (LN) and the underlying mechanism. Ten-week old MRL/LPR mice were injected with HE4 shRNA ade...
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Article
Open AccessHER2-targeted therapies in cancer: a systematic review
Abnormal alterations in human epidermal growth factor receptor 2 (HER2, neu, and erbB2) are associated with the development of many tumors. It is currently a crucial treatment for multiple cancers. Advanced in...
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Article
Influence of neuroticism on depression among college students by gender: the mediating roles of negative cognitive bias and anhedonia
Previous studies show that neuroticism has a significant impact on depression in college students. However, the mechanisms linking neuroticism and depression remain unclear. This study investigates whether neu...
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Article
Open AccessPyrotinib and chrysin synergistically potentiate autophagy in HER2-positive breast cancer
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) has been the most challenging subtype of BC, consisting of 20% of BC with an apparent correlation with poor prognosis. Despite that p...
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Article
Open AccessA nomogram for predicting breast cancer specific survival in elderly patients with breast cancer: a SEER population-based analysis
The number of elderly patients diagnosed with breast cancer is increasing worldwide. However, treatment decisions for these patients are highly variable. Although researchers have identified the effects of sur...
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Article
Open AccessCharacteristics of DNA macro-alterations in breast cancer with liver metastasis before treatment
Whole-genome doubling (WGD) has been observed in 30% of cancers, followed by a highly complex rearranged karyotype unfavourable to breast cancer's outcome. However, the macro-alterations that characterise live...
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Article
Open AccessA prospective cohort study of clinical characteristics and outcomes in Chinese patients with estrogen receptor-negative/progesterone receptor-positive early breast cancer
This study aimed to examine the clinical characteristics and outcomes of patients with estrogen receptor-negative (ER−)/progesterone receptor-positive (PR+) early breast cancer. We also aimed to investigate th...
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Article
Open AccessGlobal longitudinal strain assessment in contrast-enhanced echocardiography in breast cancer patients: a feasibility study
Left ventricular global longitudinal strain (GLS) obtained from two-dimensional speckle-tracking echocardiography (2D-STE) can reflect cancer therapy-related cardiac dysfunction in breast cancer (BC) patients,...
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Article
Open AccessMammography radiomics features at diagnosis and progression-free survival among patients with breast cancer
The associations between mammographic radiomics and breast cancer clinical endpoints are unclear. We aimed to identify mammographic radiomics features associated with breast cancer prognosis.
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Article
Open AccessAssociation between age at initial diagnosis and post-metastasis mortality among women with recurrent metastatic breast cancer in China
Little is known about whether age at initial diagnosis influences the prognosis of recurrent metastatic breast cancer (rMBC). Here, we analyzed the association between age at initial diagnosis and rMBC mortali...
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Article
Open AccessPTEN promoter methylation predicts 10-year prognosis in hormone receptor-positive early breast cancer patients who received adjuvant tamoxifen endocrine therapy
There remain a lack of biomarkers for endocrine therapy resistance in patients with breast cancer (BC), which is proving to be a great challenge. In vitro experiments have shown that downregulation of PTEN exp...
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Article
Open AccessTreatment patterns and outcomes in older women with early breast cancer: a population-based cohort study in China
Despite the proportion of elderly breast cancer patients has been consistently increasing, the optimal treatment modalities for this population have not been well explored. We summarized the treatment outcomes...
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Article
Open AccessCost-effectiveness of different surgical treatment approaches for early breast cancer: a retrospective matched cohort study from China
Both breast-conserving surgery and breast reconstruction surgery are less popular in China, although they can improve patients’ quality of life. The main reason comes from the economy. There is currently no ec...
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Article
Long-term excess body fat in adulthood and the risk of pre- and postmenopausal breast cancer in Chinese women
This study aimed to investigate the association between long-term excess body fat and breast cancer risk by studying adult weight gain together with the subsequent weight fluctuations.
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Article
Open AccessA multiple breast cancer stem cell model to predict recurrence of T1–3, N0 breast cancer
Local or distant relapse is the key event for the overall survival of early-stage breast cancer after initial surgery. A small subset of breast cancer cells, which share similar properties with normal stem cel...
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Article
Exploration of intelligent computing based on improved hybrid genetic algorithm
Aiming at the problems and shortcomings of genetic algorithm, a hybrid genetic algorithm based on chaos genetic algorithm is designed in this paper. Based on the actual situation of universities, a mathematica...
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Article
OFS plus AI or SERM vs. SERM alone in premenopausal women with hormone receptor-positive breast cancer: a prospective cohort study using the real-world database
Ovarian function suppression (OFS) plus other endocrine treatment was recommended to hormone receptor (HR)-positive breast cancer by some guidelines recently. We performed this study to validate the survival b...
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Article
Open AccessElectrical polarization induced by atomically engineered compositional gradient in complex oxide solid solution
Control of inhomogeneity in materials in order to avoid unexpected effects to the system remains a challenge. In this study, we seek to engineer inhomogeneity in materials and anticipate new properties. Throug...
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Article
Open AccessClinical significance and prognostic value of receptor conversion in hormone receptor positive breast cancers after neoadjuvant chemotherapy
Neoadjuvant chemotherapy (NAC) is widely used in advanced breast cancer patients. However, there is little known about conversion frequency of estrogen receptor (ER) and/or progesterone receptor (PR) status fo...
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Article
Trends and Present Treatment Patterns of Early Breast Cancer in Southwest China
To analyze the changing patterns of treatment and to explore the current treatment approaches for breast cancer in Southwest China, we conducted a population-based retrospective cohort study of early breast ca...
