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Article
Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms
Smc5/6 is a member of the eukaryotic structural maintenance of chromosomes (SMC) family of complexes with important roles in genome maintenance and viral restriction. However, limited structural understanding ...
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Article
Open AccessIdentification of the CONSTANS-like family in Cymbidium sinense, and their functional characterization
Cymbidium sinense is an orchid that is typically used as a potted plant, given its high-grade ornamental characteristics, and is most frequently distributed in China and SE Asia. The inability to strictly regulat...
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Article
Elucidating the binding configuration of uranium at the biotite-water interface
Understanding the binding configuration of uranium on biotite is crucial for elucidating the environmental behavior of U(VI) and addressing emergency scenarios in disposal repositories. This investigation demo...
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Article
Association of Urinary Zinc Concentrations with Dyslipidemia and Its Subtypes: Baseline Data from the Chinese Multi-Ethnic Cohort (CMEC) Study
This study elucidates the association between urinary zinc concentration and the risk of develo** dyslipidemia and its subtypes in China’s ethnic minority residents. Based on the baseline survey data of the ...
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Article
The multi-functional Smc5/6 complex in genome protection and disease
Structural maintenance of chromosomes (SMC) complexes are ubiquitous genome regulators with a wide range of functions. Among the three types of SMC complexes in eukaryotes, cohesin and condensin fold the genom...
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Article
Open AccessSmc5/6’s multifaceted DNA binding capacities stabilize branched DNA structures
Smc5/6 is an evolutionarily conserved SMC complex with roles in DNA replication and repair, as well as in viral DNA restriction. Understanding its multiple functions has been hampered by a lack of mechanistic ...
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Article
Open AccessTransient inhibition of p53 enhances prime editing and cytosine base-editing efficiencies in human pluripotent stem cells
Precise gene editing in human pluripotent stem cells (hPSCs) holds great promise for studying and potentially treating human diseases. Both prime editing and base editing avoid introducing double strand breaks...
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Article
Open AccessRtt105 regulates RPA function by configurationally stapling the flexible domains
Replication Protein A (RPA) is a heterotrimeric complex that binds to single-stranded DNA (ssDNA) and recruits over three dozen RPA-interacting proteins to coordinate multiple aspects of DNA metabolism includi...
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Article
Open AccessLong non-coding RNA OIP5-AS1 suppresses microRNA-92a to augment proliferation and metastasis of ovarian cancer cells through upregulating ITGA6
Recently, long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have been identified as essential biomarkers during development of malignancies. This study was performed to study the roles of lncRNA opa-intera...
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Article
Open AccessAuricular acupressure for adverse events following immunization related to COVID-19 vaccine injection: study protocol for a multicenter, three-arm, blinded randomized controlled trial
Some pain, fatigue, and gastrointestinal adverse events were observed in potential association with injection of COVID-19 vaccines, while there was no preventive intervention for it. We aim to investigate the ...
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Article
Open AccessUp-regulation of microRNA-135 or silencing of PCSK6 attenuates inflammatory response in preeclampsia by restricting NLRP3 inflammasome
Numerous studies have confirmed the correlation of microRNAs (miRNAs) with human disease, yet few have explored the role of miR-135 in preeclampsia (PE). This study intends to discuss miR-135’s function in inf...
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Article
Open AccessTraditional Chinese medicine auricular point acupressure for the relief of pain, fatigue, and gastrointestinal adverse reactions after the injection of novel coronavirus-19 vaccines: a structured summary of a study protocol for a multicentre, three-arm, single-blind, prospective randomized controlled trial
To investigate if traditional Chinese medicine (TCM) auricular point acupressure (APA) can alleviate and (or) reduce the pain (including injection site pain, headache, other muscle and joint pain), fatigue, an...
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Article
Q-rung orthopair fuzzy multiple attribute group decision-making method based on normalized bidirectional projection model and generalized knowledge-based entropy measure
The q-rung orthopair fuzzy sets (q-ROFSs) can serve as a generalization of intuitionistic fuzzy sets (IFSs) and Pythagorean fuzzy sets (PFSs). q-ROFSs provide more freedom for decision makers in describing the...
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Article
Open AccessStructural basis for the multi-activity factor Rad5 in replication stress tolerance
The yeast protein Rad5 and its orthologs in other eukaryotes promote replication stress tolerance and cell survival using their multiple activities, including ubiquitin ligase, replication fork remodeling and ...
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Article
Open AccessDisome-seq reveals widespread ribosome collisions that promote cotranslational protein folding
The folding of proteins is challenging in the highly crowded and sticky environment of a cell. Regulation of translation elongation may play a crucial role in ensuring the correct folding of proteins. Much of ...
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Article
Interval-Valued Intuitionistic Uncertain Linguistic Multi-attribute Decision-Making Method for Plant Location Selection with Partitioned Hamy Mean
Plant location selection (PLS) is a typical and complex multi-attribute group decision-making (MAGDM) problem, which requires consideration of several alternatives and multiple attributes. However, existing re...
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Article
Molecular Cloning and Functional Analysis of Three CONSTANS-Like Genes from Chinese Cymbidium
CONSTANS (CO) and CONSTANS-like (COL) are two centrally important flowering-related genes in the photoperiodic pathway of Cymbidium, an economically important orchid genus within the Orchidaceae. To assess how ph...
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Article
Application of convolutional neural network in predicting groundwater potential using remote sensing: a case study in southeastern Liaoning, China
With the rise of machine learning and artificial intelligence, back propagation (BP) neural network, support vector machine (SVM), random forest model, and others can be used to predict the distribution of gro...
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Article
Open AccessDNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis
DNA polymerase epsilon (Pol ε) is required for genome duplication and tumor suppression. It supports both replisome assembly and leading strand synthesis; however, the underlying mechanisms remain to be elucid...
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Article
Open AccessA formula based on autonomic test using EZSCAN and anthropometric data for diagnosis of DM in China
Clinical diagnosis of diabetes mellitus (DM) is time-consuming and invasive. This study aimed to investigate the efficacy and accuracy of EZSCAN in detecting impaired glucose tolerance (IGT) and diabetes melli...
