8 Result(s)

Article

TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis

Pneumoconiosis, caused by inhalation of mineral dusts, is a major occupational disease worldwide. Currently, there are no effective drugs owing to a lack of potential therapeutic targets during either the infl...

Jie Li, Chao Liang, Zong-Kang Zhang, **aohua Pan, Songlin Peng… in Cell Discovery (2017)

Article

Sequence determinants of specific pattern-recognition of bacterial ligands by the NAIP–NLRC4 inflammasome

The NLR apoptosis inhibitory proteins (NAIPs) function as specific cytosolic receptors for bacterial ligands to form the NAIP–NLRC4 inflammasome for anti-bacterial defenses. In mice, NAIP5/6 and NAIP2 recogniz...

**gyi Yang, Yue Zhao, Peng Li, Yi Yang, Ejuan Zhang, Maohua Zhong… in Cell Discovery (2018)

Article

Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses

Coxsackievirus A10 (CV-A10) belongs to the Enterovirus species A and is a causative agent of hand, foot, and mouth disease. Here we present cryo-EM structures of CV-A10 mature virion and native empty particle (NE...

**huan Chen, **aohua Ye, Xue-Yang Zhang, Zhengdan Zhu, **ang Zhang… in Cell Discovery (2019)

Article

Dysregulated hematopoiesis in bone marrow marks severe COVID-19

Severe coronavirus disease 2019 (COVID-19) is often indicated by lymphopenia and increased myelopoiesis; however, the underlying mechanism is still unclear, especially the alteration of hematopoiesis. It is im...

**n Wang, Yanling Wen, **aowei **e, Yang Liu, **aohua Tan, Qingxian Cai… in Cell Discovery (2021)

Article

Establishment of human distal lung organoids for SARS-CoV-2 infection

Ting Wang, Ning Zhang, Shipan Fan, Lianzheng Zhao, Wanlu Song… in Cell Discovery (2021)

Article

Genome-wide association and functional interrogation identified a variant at 3p26.1 modulating ovarian cancer survival among Chinese women

Ovarian cancer survival varies considerably among patients, to which germline variation may also contribute in addition to mutational signatures. To identify genetic markers modulating ovarian cancer outcome, ...

Hongji Dai, **nlei Chu, Qian Liang, Mengyun Wang, Lian Li, Yao Zhou… in Cell Discovery (2021)

Article

Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding

Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) exhibited prolonged high-level I...

**aohua Tang, Rui Sun, Weigang Ge, Tingting Mao, Liujia Qian… in Cell Discovery (2022)

Article

A novel recombination protein C12ORF40/REDIC1 is required for meiotic crossover formation

During meiosis, at least one crossover must occur per homologous chromosome pair to ensure normal progression of meiotic division and accurate chromosome segregation. However, the mechanism of crossover format...

Suixing Fan, Yuewen Wang, Hanwei Jiang, **aohua Jiang, Jianteng Zhou… in Cell Discovery (2023)