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Open AccessShaoxia: a web-based interactive analysis platform for single cell RNA sequencing data
In recent years, Single-cell RNA sequencing (scRNA-seq) is increasingly accessible to researchers of many fields. However, interpreting its data demands proficiency in multiple programming languages and bioinf...
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Article
Open AccessEGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1
The Hippo pathway is frequently dysregulated in cancer, leading to the unrestrained activity of its downstream targets, YAP/TAZ, and aberrant tumor growth. However, the precise mechanisms leading to YAP/TAZ ac...
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Article
Inactivation of a Gαs–PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis
Genomic alterations in GNAS, the gene coding for the Gαs heterotrimeric G protein, are associated with a large number of human diseases. Here, we explored the role of Gαs on stem cell fate decisions by using the ...
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Article
Open AccessInvolvement of potential pathways in malignant transformation from Oral Leukoplakia to Oral Squamous Cell Carcinoma revealed by proteomic analysis
Oral squamous cell carcinoma (OSCC) is one of the most common forms of cancer associated with the presence of precancerous oral leukoplakia. Given the poor prognosis associated with oral leukoplakia, and the d...
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Article
Vegetation and climate changes during the last 8660 cal. a BP in central Mongolia, based on a high-resolution pollen record from Lake Ugii Nuur
Based on modern pollen studies and reliable chronology of nine AMS 14C dates, a detailed history of vegetation and climate changes during the past 8660 cal. a BP was reconstructed by a high-resolution pollen reco...
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Process-Based Soil Erosion Simulation on a Regional Scale: The Effect of Ecological Restoration in the Chinese Loess Plateau
Land degradation caused by serious soil erosion has made the Loess Plateau one of the poorest regions in China. To improve the environmental conditions, the government has taken a number of measures of ecologi...
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Article
Spatiotemporal variations of Zr/Rb ratio in three last interglacial paleosol profiles across the Chinese Loess Plateau and its implications for climatic interpretation
The ratio of Zirconium to Rubidium (Zr/Rb) is suggested to be a better proxy for the East Asian winter monsoon strength than the widely-used grain size distribution. The rationale for the Zr/Rb proxy relies on...
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Article
Pollen-recorded climate changes between 13.0 and 7.0 14C ka BP in southern Ningxia, China
A pollen record from Haiyuan section in the southern part of Ningxia revealed a detailed history of vegetation variation and associated climate changes during the period from ∼13.0 to ∼7.0 14C ka BP. A steppe lan...
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Article
Holocene climatic and environmental changes recorded in Baahar Nuur Lake core in the Ordos Plateau, Inner Mongolia of China
A 5.3 m lake core was drilled in Baahar Nuur Lake in the Ordos Plateau, and measurements of mean grain size, organic δ 13C (δ 13Corg), organic carbon content (TOC), C/N, carbonate ...
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Article
Holocene abrupt climate shifts recorded in Gun Nuur lake core, northern Mongolia
A continuous 7.44 m lake core was successfully drilled at Gun Nuur Lake, northern Mongolia, and analyses on environment magnetic parameters, organic matter content and organic λ13C were conducted in an attempt to...
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Article
Evidence of a humid mid-Holocene in the western part of Chinese Loess Plateau
Field works show that the wetland/swamp layers were distributed ubiquitously in the western part of the Chinese Loess Plateau. Universality of the wetland/swampy layer and the consistency of the age reveal tha...
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Late Glacial and Holocene vegetation history and paleoclimate of the Tengger Desert, northwestern China
Sediments spanning the last 30000 yr BP were obtained from two sections in the southern part of the Tengger Desert, northwestern China (38°10′46″N, 102°45′53″E). The pollen assemblage suggested a Picea forest dom...
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Article
Palaeolake and palaeoenvironment between 42 and 18 kaBP in tengger desert, NW China
Comprehensive field investigations and laboratory analyses show that palaeolakes, including freshmesohaline water Megalake Tengger and other semi-connected, isolated water bodies, during late Pleistocene cover...