5 Result(s)
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Article
Open AccessShaoxia: a web-based interactive analysis platform for single cell RNA sequencing data
In recent years, Single-cell RNA sequencing (scRNA-seq) is increasingly accessible to researchers of many fields. However, interpreting its data demands proficiency in multiple programming languages and bioinf...
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Article
Open AccessEGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1
The Hippo pathway is frequently dysregulated in cancer, leading to the unrestrained activity of its downstream targets, YAP/TAZ, and aberrant tumor growth. However, the precise mechanisms leading to YAP/TAZ ac...
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Article
Inactivation of a Gαs–PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis
Genomic alterations in GNAS, the gene coding for the Gαs heterotrimeric G protein, are associated with a large number of human diseases. Here, we explored the role of Gαs on stem cell fate decisions by using the ...
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Article
Open AccessInvolvement of potential pathways in malignant transformation from Oral Leukoplakia to Oral Squamous Cell Carcinoma revealed by proteomic analysis
Oral squamous cell carcinoma (OSCC) is one of the most common forms of cancer associated with the presence of precancerous oral leukoplakia. Given the poor prognosis associated with oral leukoplakia, and the d...
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Process-Based Soil Erosion Simulation on a Regional Scale: The Effect of Ecological Restoration in the Chinese Loess Plateau
Land degradation caused by serious soil erosion has made the Loess Plateau one of the poorest regions in China. To improve the environmental conditions, the government has taken a number of measures of ecologi...
