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Open AccessEndothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance
Obesity and exercise intolerance greatly reduce the life quality of older people. Prolyl hydroxylase domain-containing protein 2 (PHD2) is an important enzyme in modulating hypoxia-inducible factor-alpha (HIF)...
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Article
Open AccessN6-methyladenosine modification of circMARK2 enhances cytoplasmic export and stabilizes LIN28B, contributing to the progression of Wilms tumor
The potential involvement of circular RNAs (circRNAs) and N6-methyladenosine (m6A) modification in the progression of Wilms tumor (WT) has not been fully elucidated. This study investigates the regulatory mechani...
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Article
Open AccessResearch on intelligent monitoring technology for roof damage of traditional Chinese residential buildings based on improved YOLOv8: taking ancient villages in southern Fujian as an example
In the process of preserving historical buildings in southern Fujian, China, it is crucial to provide timely and accurate statistical data to classify the damage of traditional buildings. In this study, a meth...
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Article
Author Correction: Light-based vat-polymerization bioprinting
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Open AccessA clinical tool to predict overall survival of elderly patients with soft tissue sarcoma after surgical resection
With the aging world population, the incidence of soft tissue sarcoma (STS) in the elderly gradually increases and the prognosis is poor. The primary goal of this research was to analyze the relevant risk fact...
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Article
Open AccessReal-World Evidence of FOLFIRI Combined with Anti-Angiogenesis Inhibitors or Anti-EGFR Antibodies for Patients with Early Recurrence Colorectal Cancer After Adjuvant FOLFOX/CAPOX Therapy: A Japanese Claims Database Study
Oxaliplatin-containing adjuvant regimens (folinic acid, fluorouracil, and oxaliplatin/capecitabine and oxaliplatin [FOLFOX/CAPOX]) are used after curative resection of colorectal cancer (CRC). However, real-wo...
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Article
Open AccessMycobacterium tuberculosis produces d-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice
Adaptation to hypoxia is a major challenge for the survival of Mycobacterium tuberculosis (Mtb) in vivo. Interferon (IFN)-γ-producing CD8+ T cells contribute to control of Mtb infection, in part by promoting anti...
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Article
Open AccessCabozantinib and nivolumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial
Supplementation with CBM588, a bifidogenic live bacterial product, has been associated with improved clinical outcomes in persons with metastatic renal cell carcinoma (mRCC) receiving nivolumab and ipilimumab....
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Article
Open AccessCompressive confocal microscopy imaging at the single-photon level with ultra-low sampling ratios
Laser-scanning confocal microscopy serves as a critical instrument for microscopic research in biology. However, it suffers from low imaging speed and high phototoxicity. Here we build a novel deep compressive...
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Article
Open AccessTumor-associated characteristics and immune dysregulation in nasopharyngeal carcinoma under the regulation of m7G-related tumor microenvironment cells
Nasopharyngeal carcinoma (NPC) is a type of malignant tumor with high morbidity. Aberrant levels of N7-methylguanosine (m7G) are closely associated with tumor progression. However, the characteristics of the t...
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Article
Open AccessSMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2− breast cancer
Endocrine resistance poses a significant clinical challenge for patients with hormone receptor-positive and human epithelial growth factor receptor 2-negative (HR + HER2−) breast cancer. Dysregulation of estro...
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Open AccessDietary factors in relation to hypertension: a mendelian randomization study
Observational studies have elucidated the associations between dietary factors and hypertension. Nevertheless, the exploration of these relationships using Mendelian randomization remains scarce currently.
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Article
Open AccessImpact of groundwater nitrogen legacy on water quality
The loss of agricultural nitrogen (N) is a leading cause of global eutrophication and freshwater and coastal hypoxia. Despite regulatory efforts, such as the European Union’s Nitrogen Directive, high concentra...
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Article
Open AccessLocal strain heterogeneity and damage mechanisms in zirconia particle-reinforced TRIP steel MMCs: in situ tensile testing with digital image processing
In this work, the microstructural deformation and damage mechanisms of TRIP steel metal matrix composites (MMCs) reinforced with Magnesia Partially Stabilized Zirconia (Mg-PSZ) particles are investigated by em...
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Article
Open AccessDual-frequency to five-frequency real-time precise point positioning using new BDS-3 PPP-B2b service
BeiDou global navigation satellite system (BDS-3), a developed GNSS by China, has the ability to support five different signals, including B1I, B3I, B1C, B2a, and B2b. Meanwhile, BDS-3 has officially provided ...
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Article
Open AccessAlpha-Hederin induces incomplete autophagic injury in non-small cell lung cancer by interfering with the lysosomal acidification
Lung cancer is the most common oncological disease worldwide, with non-small cell lung cancer accounting for approximately 85% of lung cancer cases. α-Hederin is a monodesmosidic triterpenoid saponin isolated ...
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Article
Open AccessIdentification and molecular map** of resistance genes for adult-plant resistance to stripe rust in spring wheat germplasm line PI660076
Wheat is one of the major food crops worldwide. Stripe rust can cause a great loss of wheat yield, especially when the disease is prevalent. Chemical control not only causes the loss of resistance to stripe ru...
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Open AccessUnraveling the treatment effects of huanglian jiedu decoction on drug-induced liver injury based on network pharmacology, molecular docking and experimental validation
Huanglian Jiedu Decoction (HJD) is a well-known Traditional Chinese Medicine formula that has been used for liver protection in thousands of years. However, the therapeutic effects and mechanisms of HJD in tre...
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Open AccessIdentification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations
Hotspot driver mutations presented by human leukocyte antigens might be recognized by anti-tumor T cells. Based on their advantages of tumor-specificity and immunogenicity, neoantigens derived from hotspot mut...
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Article
Open AccessMachine intelligence accelerated design of conductive MXene aerogels with programmable properties
Designing ultralight conductive aerogels with tailored electrical and mechanical properties is critical for various applications. Conventional approaches rely on iterative, time-consuming experiments across a ...
