48 Result(s)
within
**ao-yu Zhao
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessControl of cotton fibre elongation by a homeodomain transcription factor GhHOX3
Cotton fibres are unusually long, single-celled epidermal seed trichomes and a model for plant cell growth, but little is known about the regulation of fibre cell elongation. Here we report that a homeodomain-...
-
Article
Open AccessCharacterization of a Novel Reassortant Influenza A Virus (H2N2) from a Domestic Duck in Eastern China
While H2N2 viruses have been sporadically isolated from wild and domestic birds, H2N2 viruses have not been detected among human populations since 1968. Should H2N2 viruses adapt to domestic poultry they may p...
-
Article
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis
The role of the unfolded protein response (UPR) in tissue homeostasis remains largely unknown. Here we find that loss of Mst1/2, the mammalian Hippo orthologues, or their regulator WW45, leads to a remarkably ...
-
Article
Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations
Age-related macular degeneration (AMD) is a leading cause of irreversible central blindness among the elderly worldwide. We use exome sequencing to analyse nonsynonymous single-nucleotide variants (SNVs) acros...
-
Article
Open AccessTransforming berberine into its intestine-absorbable form by the gut microbiota
The gut microbiota is important in the pathogenesis of energy-metabolism related diseases. We focused on the interaction between intestinal bacteria and orally administered chemical drugs. Oral administration ...
-
Article
Open AccessGenetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone
The genome sequences of 175 Ebola virus from five districts in Sierra Leone, collected during September–November 2014, show that the rate of virus evolution seems to be similar to that observed during previous...
-
Article
Open AccessGossypium barbadense genome sequence provides insight into the evolution of extra-long staple fiber and specialized metabolites
Of the two cultivated species of allopolyploid cotton, Gossypium barbadense produces extra-long fibers for the production of superior textiles. We sequenced its genome (AD)2 and performed a comparative analysis. ...
-
Article
Erratum: Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone
Nature 524, 93–96 (2015); doi:10.1038/nature14490 This Letter should have contained an associated Creative Commons statement in the Author Information section. In addition, the Fig. 3c legend should have state...
-
Article
Open AccessActivation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection
AMPK is a serine/threonine protein kinase that acts as a positive regulator of autophagy, by phosphorylating ULK1 at specific sites. A previous study demonstrated activation of the macroautophagic system in sc...
-
Article
Open AccessCharacterization of the promoter region of the bovine long-chain acyl-CoA synthetase 1 gene: Roles of E2F1, Sp1, KLF15 and E2F4
The nutritional value and eating qualities of beef are enhanced when the unsaturated fatty acid content of fat is increased. Long-chain acyl-CoA synthetase 1 (ACSL1) plays key roles in fatty acid transport and...
-
Article
Open AccessmiR-203 inhibits proliferation and self-renewal of leukemia stem cells by targeting survivin and Bmi-1
Drug resistance is one of the leading causes of failed cancer therapy in the treatment of acute myeloid leukemia. Although the mechanisms of resistance are poorly understood, they may be related to the presenc...
-
Article
Open AccesshTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA-29a
Human telomerase reverse transcriptase (hTERT) plays a key role in tumor invasion and metastasis, but the mechanism of its involvement in these processes is not clear. The purpose of this study is to investiga...
-
Article
Open AccessIntegrated Droplet-Based Microextraction with ESI-MS for Removal of Matrix Interference in Single-Cell Analysis
Integrating droplet-based microfluidics with mass spectrometry is essential to high-throughput and multiple analysis of single cells. Nevertheless, matrix effects such as the interference of culture medium and...
-
Article
Open AccessAssociation of CYP2C19 Polymorphisms with the Clinical Efficacy of Clopidogrel Therapy in Patients Undergoing Carotid Artery Stenting in Asia
The CYP2C19 gene plays a detrimental role in the metabolism of clopidogrel. This study aimed to investigate the association between CYP2C19 polymorphisms and the clinical efficacy of clopidogrel therapy in patien...
-
Article
Open AccessPenicimenolides A-F, Resorcylic Acid Lactones from Penicillium sp., isolated from the Rhizosphere Soil of Panax notoginseng
Five new 12-membered resorcylic acid lactone derivatives, penicimenolides A-E (1–5), one new ring-opened resorcylic acid lactone derivative penicimenolide F (6) and six known biogenetically related derivatives (7...
-
Article
Open AccessFibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury
Fibroblast growth factor 21 (FGF21) is a hepatokine that regulates glucose and lipid metabolism in the liver. We sought to determine the role of FGF21 in hepatic steatosis in mice exposed to chronic alcohol tr...
-
Article
Open AccessComparative mitochondrial genomics toward exploring molecular markers in the medicinal fungus Cordyceps militaris
Cordyceps militaris is a fungus used for develo** health food, but knowledge about its intraspecific differentiation is limited due to lack of efficient markers. Herein, we assembled the mitochondrial genomes o...
-
Article
Open AccessA kind of universal quantum secret sharing protocol
Universality is an important feature, but less researched in quantum communication protocols. In this paper, a kind of universal quantum secret sharing protocol is investigated. Firstly, we design a quantum se...
-
Article
Open AccessNur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation
Gluconeogenesis, an essential metabolic process for hepatocytes, is downregulated in hepatocellular carcinoma (HCC). Here we show that the nuclear receptor Nur77 is a tumour suppressor for HCC that regulates g...
-
Article
Open AccessEnhanced osteogenesis and angiogenesis by mesoporous hydroxyapatite microspheres-derived simvastatin sustained release system for superior bone regeneration
Biomaterials with both excellent osteogenic and angiogenic activities are desirable to repair massive bone defects. In this study, simvastatin with both osteogenic and angiogenic activities was incorporated in...
