5 Result(s)
within
**ao-xiang **e
English
Biochemistry, general
Immunology
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Article
Open AccessHalofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer
Autophagy has a key role in metabolism and impacts on tumorigenesis. Our previous study found that halofuginone (HF) exerts anticancer activity in colorectal cancer (CRC) by downregulating Akt/mTORC1 (mechanis...
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Article
Open AccesscircHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA
Myofibroblasts predominantly emerging through fibroblast-to-myofibroblast transition (FMT) are considered to be the key collagen-producing cells in pulmonary fibrosis. Circular RNAs (circRNAs) are important pl...
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Article
Open AccessDDX5-targeting fully human monoclonal autoantibody inhibits proliferation and promotes differentiation of acute promyelocytic leukemia cells by increasing ROS production
Acute promyelocytic leukemia (APL) therapy involves the compounds cytotoxic to both malignant tumor and normal cells. Relapsed APL is resistant to subsequent chemotherapy. Novel agents are in need to kill APL ...
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Article
Open AccessG-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence
Aging is one of the most prominent risk factors for heart failure. Myeloid-derived suppressor cells (MDSCs) accumulate in aged tissue and have been confirmed to be associated with various aging-related disease...
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Article
Transcriptional regulation of small heat shock protein genes by heat shock factor 1 (HSF1) in Liriomyza trifolii under heat stress
Small heat shock proteins (sHSPs) function as molecular chaperones in multiple physiological processes and are active during thermal stress. sHSP expression is controlled by heat shock transcription factor (HSF);...
