Phase-Separated Biomolecular Condensates
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Life Sciences
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Article
CA1 Modulates the Osteogenic Differentiation of Dental Follicle Stem Cells by Activating the BMP Signaling Pathway In Vitro
Carbonic anhydrase 1 (CA1) has been found to be involved in osteogenesis and osteoclast in various human diseases, but the molecular mechanisms are not completely understood. In this study, we aim to use siRNA...
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Endothelial extracellular vesicles induce acute lung injury via follistatin-like protein 1
Cardiopulmonary bypass has been speculated to elicit systemic inflammation to initiate acute lung injury (ALI), including acute respiratory distress syndrome (ARDS), in patients after cardiac surgery. We previ...
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LncRNA LY6E-DT and its encoded metastatic-related protein play oncogenic roles via different pathways and promote breast cancer progression
Abnormal long noncoding RNA (lncRNA) expression plays an important role in tumor invasion and metastasis. Here, we show that lncRNA LY6E divergent transcript (LY6E-DT) levels are increased in breast cancer (BC...
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Labidochromis caeruleus cichlid preference for background colour varied between individuals and groups but did not vary for body colour of other fish
Investigations of colour-related behaviours, e.g. the context dependence of colour preferences in animal species are fundamental for understanding colour discrimination mechanisms and evolution of colour patte...
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Transcriptomic and physiological analysis reveal phytohormone and phenylpropanoid biosynthesis in root of Cynanchum auriculatum
Baishouwu (Cynanchum auriculatum), a medicinal and food dual-use plant, has been cultivated for centuries and is favored by consumers. C. auriculatum tuberous roots contain enormous amounts of flavonoids, lignin,...
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Open AccessAmplicon-based metagenomic association analysis of gut microbiota in relation to egg-laying period and breeds of hens
The gut microbiota plays an essential role in maintaining gut homeostasis and improving performance, with the composition of microbial communities visibly differing across different laying stages in hens and s...
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Dirigent gene editing of gossypol enantiomers for toxicity-depleted cotton seeds
Axial chirality of biaryls can generate varied bioactivities. Gossypol is a binaphthyl compound made by cotton plants. Of its two axially chiral isomers, (−)-gossypol is the bioactive form in mammals and has a...
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Modeling human gray hair by irradiation as a valuable tool to study aspects of tissue aging
As one of the earliest and most visible phenomenon of aging, gray hair makes it a unique model system for investigating the mechanism of aging. Ionizing radiation successfully induces gray hair in mice, and al...
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Open AccessAgMYB5, an MYB transcription factor from celery, enhanced β-carotene synthesis and promoted drought tolerance in transgenic Arabidopsis
Water shortage caused by global warming seriously affects the yield and quality of vegetable crops. β-carotene, the lipid-soluble natural product with important pharmacological value, is abundant in celery. Tr...
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Open AccessCD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor
Hepatocellular carcinoma (HCC) is an immunotherapy-resistant malignancy characterized by high cellular heterogeneity. The diversity of cell types and the interplay between tumor and non-tumor cells remain to b...
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Open AccessA patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating Kv1.1
Autosomal dominant lateral temporal epilepsy (ADLTE) is an inherited syndrome caused by mutations in the leucine-rich glioma inactivated 1 (LGI1) gene. It is known that functional LGI1 is secreted by excitator...
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Open AccessOmics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene
Global control of the tuberculosis epidemic is threatened by increasing prevalence of drug resistant M. tuberculosis isolates. Many genome-wide studies focus on SNP-associated drug resistance mechanisms, but drug...
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LncRNA XIST promotes mitochondrial dysfunction of hepatocytes to aggravate hepatic fibrogenesis via miR-539-3p/ADAMTS5 axis
A previous study indicated that long non-coding RNA X-inactive-specific transcript (XIST) promoted ethanol-induced HSCs autophagy and activation. Considering the critical role of HSC activation in hepatic fibr...
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Open Accessc-MYC mediates the crosstalk between breast cancer cells and tumor microenvironment
The MYC oncogenic family is dysregulated in diverse tumors which is generally linked to the poor prognosis of tumors. The members in MYC family are transcription factors which are responsible for the regulatio...
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Identification of resistance of Guangxi (Oryza rufipogon Griff.) to white-backed planthopper with stem evaluation method
White-backed planthopper (WBPH) is a devastating pest of rice, which significantly reduces production and causes millions of dollars in losses worldwide annually. Screening of germplasm resources with resistan...
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Astragalus Polysaccharides Reduce High-glucose-induced Rat Aortic Endothelial Cell Senescence and Inflammasome Activation by Modulating the Mitochondrial Na+/Ca2+ Exchanger
Vascular endothelial cells play a vital role in atherosclerotic changes and the progression of cardiovascular disease in older adults. Previous studies have indicated that Astragalus polysaccharides (APS), a main...
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Open AccessCorrection to: Predicting global numbers of teleomorphic ascomycetes
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Open AccessPredicting global numbers of teleomorphic ascomycetes
Sexual reproduction is the basic way to form high genetic diversity and it is beneficial in evolution and speciation of fungi. The global diversity of teleomorphic species in Ascomycota has not been estimated....
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CTHRC1 promotes growth, migration and invasion of trophoblasts via reciprocal Wnt/β-catenin regulation
Preeclampsia (PE) is a pregnancy complication that is characterized by high blood pressure and is associated with high maternal and fetal morbidities. At a mechanistic level, PE is characterized by reduced inv...
