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  1. No Access

    Article

    Contributory presentations/posters

    N. Manoj, V. R. Srinivas, A. Surolia, M. Vijayan, K. Suguna… in Journal of Biosciences (1999)

  2. No Access

    Article

    Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease

    The authors show that a nonpsychoactive cannabinoid, DH-CBD, can rescue exaggerated acoustic startle phenotypes caused by startle disease–causing point mutations in the glycine receptor (GlyR) α1 subunit. Homo...

    Wei **ong, Shao-Rui Chen, Liming He, Kejun Cheng, Yi-Lin Zhao… in Nature Neuroscience (2014)

  3. No Access

    Article

    G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition

    Chronic neuropathic pain is associated with K+ channel downregulation in primary sensory neurons. The authors show that G9a, a histone-modifying enzyme, is required for transcriptional repression of K+ channel–as...

    Geoffroy Laumet, Judit Garriga, Shao-Rui Chen, Yuhao Zhang… in Nature Neuroscience (2015)

  4. No Access

    Article

    Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain

    Chronic neuropathic pain is a debilitating condition that remains challenging to treat. Glutamate N-methyl-d-aspartate receptor (NMDAR) antagonists have been used to treat neuropathic pain, but the exact sites of...

    Meichun Deng, Shao-Rui Chen, Hui-Lin Pan in Cellular and Molecular Life Sciences (2019)

  5. Article

    Comparison of epidemiological and clinical characteristics of COVID-19 patients with and without Wuhan exposure

    A novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in Wuhan, China, has been rapidly spreading around the world. This study investigates the epidemiologic...

    Jiang-shan Lian, Huan Cai, Shao-rui Hao, ** **… in Journal of Zhejiang University-SCIENCE B (2020)

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  6. Article

    Interferon-α2b spray inhalation did not shorten virus shedding time of SARS-CoV-2 in hospitalized patients: a preliminary matched case-control study

    Currently, there are no drugs that have been proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Because of its broad antiviral activity, interferon (IFN) should be eva...

    Shao-rui Hao, Ren Yan, Shan-yan Zhang… in Journal of Zhejiang University-SCIENCE B (2020)

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  7. No Access

    Article

    Tanshinone IIA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages

    Metabolic reprogramming is associated with NLRP3 inflammasome activation in activated macrophages, contributing to inflammatory responses. Tanshinone IIA (Tan-IIA) is a major constituent from Salvia miltiorrhiza ...

    Qiu-yan Liu, Yu Zhuang, **an-rui Song, Qun Niu… in Acta Pharmacologica Sinica (2021)

  8. Article

    Open Access

    An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer

    Endometrial cancer (EC) is one of the most common gynecological malignancies globally, and the development of innovative, effective drugs against EC remains a key issue. Phytoestrogen kaempferol exhibits anti-...

    Guan-Yu Ruan, Li-**ang Ye, Jian-Song Lin, Hong-Yu Lin… in Journal of Translational Medicine (2023)

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  9. No Access

    Article

    Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease

    Cyclic GMP-AMP synthase (cGAS), a cytosolic DNA sensor, acts as a nucleotidyl transferase that catalyzes ATP and GTP to form cyclic GMP-AMP (cGAMP) and plays a critical role in innate immunity. Hyperactivation...

    Jia Song, Rui-rui Yang, Jie Chang, Ya-dan Liu, Cheng-hao Lu… in Acta Pharmacologica Sinica (2023)

  10. No Access

    Article

    First-line pyrotinib in advanced HER2-mutant non-small-cell lung cancer: a patient-centric phase 2 trial

    To explore targeted treatment options in patients with non-small-cell lung cancer (NSCLC) with rare genetic mutations in the context of a patient-centric clinical trial, we initiated, in parallel, a phase 2 ad...

    Si-Yang Maggie Liu, Hai-Yan Tu, Xue-Wu Wei, Hong-Hong Yan… in Nature Medicine (2023)

  11. No Access

    Article

    Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy

    Among the numerous complications of diabetes mellitus, diabetic wounds seriously affect patients’ quality of life and result in considerable psychological distress. Promoting blood vessel regeneration in wound...

    Zhen Lin, Lu-yao Li, Lu Chen, Chen **, Yue Li, Lan Yang… in Acta Pharmacologica Sinica (2024)