8 Result(s)
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Article
Open AccessSildenafil ameliorates cardiomyopathy in dystrophin-null (mdx) mice
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Article
Open AccessMolecular targets for PDE inhibitor-mediated improvement of cardiac dysfunction in the mdx mouse?
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Article
Two new sesquiterpenoids from endophytic fungus J3 isolated from Mangrove Plant Ceriops tagal
Two new sesquiterpenoids, named 2α-hydroxyxylaranol B (1) and 4β-hydroxyxylaranol B (2), together with a known diterpenoid 3,4-seco-sonderianol (3) were isolated from the fermentation of endophytic fungus J3 of C...
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Article
Antimicrobial glycoalkaloids from the tubers of Stephania succifera
Three new glycoalkaloids, N-formyl-asimilobine-2-O-β-d-glucoside (1), (−)-1-O-β-d-glucoside-8-oxotetrahydropalmatine (2), and 1-N-monomethylcarbamate-argentinine-3-O-β-d-glucoside (3) were isolated from tubers of...
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Article
Toxicarioside N induces apoptosis in human gastric cancer SGC-7901 cell by activating the p38MAPK pathway
Natural plant compounds with potent proliferation inhibition and apoptosis induction properties have been screened as novel anticancer drugs. Toxicarioside N (Tox N) was isolated from the seeds of the tropical...
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Autophagy plays a protective role against apoptosis induced by toxicarioside N via the Akt/mTOR pathway in human gastric cancer SGC-7901 cells
Toxicarioside N (Tox N), a natural product extract from Antiaris toxicaria, has been reported to induce apoptosis in human gastric cancer cells. However, the mechanism and actual role of autophagy in Tox N-induce...
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Article
Limonoids from the roots of Trichilia sinensis and their cytotoxicities
Six new compounds (1–4, 8, 10), along with six known limonoids (5–7, 9, 11, 12), were isolated from the roots of Trichilia sinensis. Their structures were elucidated on the basis of extensive spectroscopic method...
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Article
Involvement of proBDNF in Monocytes/Macrophages with Gastrointestinal Disorders in Depressive Mice
Major depressive disorders (MDD) are often comorbid with the gastrointestinal (GI) disorders. Brain-derived neurotrophic factor precursor (proBDNF) has been reported to contribute to the development of depress...
